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    Chiral fused [1,2]imidazo[4,5-c] ring compounds
    1.
    发明授权
    Chiral fused [1,2]imidazo[4,5-c] ring compounds 有权
    手性稠合[1,2]咪唑并[4,5-c]环化合物

    公开(公告)号：US08207162B2

    公开(公告)日：2012-06-26

    申请号：US13090385

    申请日：2011-04-20

    申请人： George W. Griesgraber ,  Sarah J. Slania

    发明人： George W. Griesgraber ,  Sarah J. Slania

    IPC分类号： A61K31/4745 ,  C07D487/22

    CPC分类号： C07D498/14 ,  C07D471/14 ,  C07D498/22

    摘要： Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)— group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译： 熔融[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[4 ，5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶）在咪唑的1位上的稠环上带有-CH（-X1-R1） - 基团 公开了含有化合物的药物组合物，中间体，制备该化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

    Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
    2.
    发明授权
    Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds 有权
    取代的手性稠合[1,2]咪唑并[4,5-c]环化合物

    公开(公告)号：US08034938B2

    公开(公告)日：2011-10-11

    申请号：US11813052

    申请日：2005-12-29

    申请人： George W. Griesgraber ,  Tushar A. Kshirsagar ,  Sarah J. Slania ,  Michael E. Danielson

    发明人： George W. Griesgraber ,  Tushar A. Kshirsagar ,  Sarah J. Slania ,  Michael E. Danielson

    IPC分类号： C07D491/052 ,  C07D491/147 ,  A61K31/436

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—R1)— group in the fused ring at the 1-position of the imidazo ring, wherein R1 includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译： 取代的稠合[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[ 4,5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶）在咪唑环1位的稠环中具有-CH（-R1） - 基 其中R1包括官能团，例如酰胺，磺酰胺，脲，氨基甲酸酯，酯，酮，醚，前述砜，肟或羟胺的硫代类似物，含有这些化合物的药物组合物，中间体， 公开了使这些化合物和这些化合物用作免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。

    Substituted chiral fused [1,2]imidazo[4,5-C] ring compounds
    3.
    发明授权
    Substituted chiral fused [1,2]imidazo[4,5-C] ring compounds 有权
    取代的手性稠合[1,2]咪唑并[4,5-C]环化合物

    公开(公告)号：US08350034B2

    公开(公告)日：2013-01-08

    申请号：US13196131

    申请日：2011-08-02

    申请人： George W. Griesgraber ,  Tushar A. Kshirsagar ,  Sarah J. Slania ,  Michael E. Danielson

    发明人： George W. Griesgraber ,  Tushar A. Kshirsagar ,  Sarah J. Slania ,  Michael E. Danielson

    IPC分类号： C07D401/04 ,  A61K31/438

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—R1)— group in the fused ring at the 1-position of the imidazo ring, wherein R1 includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译： 取代的稠合[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[ 4,5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶）在咪唑环1位的稠环中具有-CH（-R1） - 基 其中R1包括官能团，例如酰胺，磺酰胺，脲，氨基甲酸酯，酯，酮，醚，前述砜，肟或羟胺的硫代类似物，含有这些化合物的药物组合物，中间体， 公开了使这些化合物和这些化合物用作免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。

    SUBSTITUTED CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS
    8.
    发明申请
    SUBSTITUTED CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS 有权
    取代的CHIRAL FUSED [1,2]咪唑并[4,5-c]环化合物

    公开(公告)号：US20110293654A1

    公开(公告)日：2011-12-01

    申请号：US13196131

    申请日：2011-08-02

    申请人： George W. Griesgraber ,  Tushar A. Kshirsagar ,  Sarah J. Slania ,  Michael E. Danielson

    发明人： George W. Griesgraber ,  Tushar A. Kshirsagar ,  Sarah J. Slania ,  Michael E. Danielson

    IPC分类号： A61K31/5383 ,  A61P37/04 ,  C07D498/14

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—R1)— group in the fused ring at the 1-position of the imidazo ring, wherein R1 includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译： 取代的稠合[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[ 4,5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶）在咪唑环1位的稠环中具有-CH（-R1） - 基 其中R1包括官能团，例如酰胺，磺酰胺，脲，氨基甲酸酯，酯，酮，醚，前述砜，肟或羟胺的硫代类似物，含有这些化合物的药物组合物，中间体， 公开了使这些化合物和这些化合物用作免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。