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1.发明授权Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity 有权具有多个电极/传感器能力和基于感测到的内在活动的刺激的植入式医疗装置公开(公告)号：US08600521B2
公开(公告)日：2013-12-03
申请号：US11045602
申请日：2005-01-27
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/05 , A61B5/4094 , A61N1/36071 , A61N1/36082 , A61N1/36114
摘要： In one embodiment, an implantable neurostimulator comprises a pulse generator that generates an electrical pulse signal to stimulate a neural structure in a patient, a stimulation lead assembly coupled to the pulse generator for delivering the electrical pulse signal to the neural structure, a plurality of sensors coupled to the pulse generator, and sensor select logic. Each sensor is individually selectable and the sensor select logic selects any two or more of the plurality of sensors for sensing a voltage difference between the selected sensors. In other embodiments, two or more physiologic parameters are sensed. In yet another embodiment, a method comprises sensing intrinsic electrical activity on a person's nerve and stimulating the nerve based on the sensed intrinsic electrical activity of the nerve.
摘要翻译： 在一个实施例中，可植入神经刺激器包括产生电脉冲信号以刺激患者中的神经结构的脉冲发生器，耦合到脉冲发生器的刺激引线组件，用于将电脉冲信号传递到神经结构，多个传感器 耦合到脉冲发生器和传感器选择逻辑。 每个传感器可单独选择，传感器选择逻辑选择多个传感器中的任何两个或多个传感器，用于感测所选传感器之间的电压差。 在其他实施例中，感测到两个或更多生理参数。 在另一个实施例中，一种方法包括基于感测到的神经内在电活动来感测人的神经上的固有电活动并刺激神经。
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公开(公告)号：US08565881B2
公开(公告)日：2013-10-22
申请号：US12820841
申请日：2010-06-22
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/3708 , A61N1/378
摘要： A method and an apparatus for projecting an end of service (EOS) and/or an elective replacement indication (ERI) of a component in an implantable device is provided. The method comprises measuring the measured voltage of the energy storage device, and determining whether the measured voltage is less than a transition voltage. When the measured voltage is less than the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the measured voltage. When the measured voltage is greater than or equal to the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the total charge depleted. The transition voltage is a voltage associated with the transition point of non-linearity in the battery voltage depletion curve.
摘要翻译： 提供了一种用于在可植入装置中投射组件的服务结束（EOS）和/或选择性替换指示（ERI）的方法和装置。 该方法包括测量能量存储装置的测量电压，以及确定测得的电压是否小于转换电压。 当测量的电压小于转换电压时，确定剩余的能量储存装置的使用时间是基于所测量的电压的函数。 当测量的电压大于或等于转换电压时，确定能量存储装置的使用结束之前剩余的时间是基于耗尽的总电荷的函数。 转换电压是与电池电压耗尽曲线中的非线性转变点相关的电压。
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公开(公告)号：US07489561B2
公开(公告)日：2009-02-10
申请号：US11257267
申请日：2005-10-24
IPC分类号： G11C11/34
CPC分类号： A61N1/37264
摘要： A device comprises a stimulus generator comprising an instruction processor. The stimulus generator is configured to deliver stimuli to a biological tissue. The device also comprises a non-volatile memory for storing instructions directly executable by the instruction processor, the instructions controlling, at least in part, the operation of the device. The instruction processor generates an erase control signal to erase at least a segment of the non-volatile memory and a write control signal to write one or more new instructions to at least a segment of the non-volatile memory, thereby modifying the operation of the device.
摘要翻译： 一种装置包括一个包括指令处理器的刺激发生器。 刺激发生器被配置为将刺激递送到生物组织。 该设备还包括用于存储可由指令处理器直接执行的指令的非易失性存储器，该指令至少部分地控制该设备的操作。 指令处理器产生擦除控制信号以擦除非易失性存储器的至少一个段和写入控制信号，以将一个或多个新指令写入非易失性存储器的至少一个段，由此修改 设备。
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公开(公告)号：US20080103532A1
公开(公告)日：2008-05-01
申请号：US11588512
申请日：2006-10-27
IPC分类号： A61N1/36
CPC分类号： A61N1/3605 , A61N1/36064 , A61N1/36082
摘要： In some embodiments, a method comprises providing an electrical signal to a nerve to evoke an action potential. The nerve thereby enters a refractory period in which the nerve is in a refractory state. The method further comprises, during the refractory period, providing an electrical signal to the nerve thereby altering the refractory period of the nerve or non-target tissues.
摘要翻译： 在一些实施例中，一种方法包括向神经提供电信号以引起动作电位。 因此神经进入神经处于难治状态的难治期。 该方法还包括在不应期内，向神经提供电信号，从而改变神经或非靶组织的不应期。
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公开(公告)号：US20070016263A1
公开(公告)日：2007-01-18
申请号：US11180745
申请日：2005-07-13
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/36082 , A61N1/36114 , A61N1/375
摘要： A method, system, and an apparatus for providing a therapy neurostimulation signal. The apparatus of the present invention includes a sealed housing being of a total volume of less than about 14.5 cc and a power supply contained within the sealed housing. The power supply includes a charge capacity of at least about 100 milliAmpHours. The apparatus also includes a controller to control an operation of the power supply and to provide an electrical neurostimulation signal for stimulating a portion of a neural tissue. The present invention also provides for implementing an interrupt-driven architecture into an implantable medical device.
摘要翻译： 一种用于提供治疗神经刺激信号的方法，系统和装置。 本发明的装置包括总体积小于约14.5cc的密封壳体和包含在密封壳体内的电源。 电源包括至少约100毫安小时的充电容量。 该装置还包括控制器，用于控制电源的操作并提供用于刺激神经组织的一部分的电神经刺激信号。 本发明还提供了将中断驱动架构实现到可植入医疗装置中。
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公开(公告)号：US5954751A
公开(公告)日：1999-09-21
申请号：US7665
申请日：1998-01-15
CPC分类号： A61N1/375 , A61N1/3758 , H05K1/141 , H05K1/181
摘要： An implantable cardiac defibrillator is provided. The implantable cardiac defibrillator includes a can, a storage cell for powering the defibrillator, and a circuit module disposed in the can for controlling the defibrillator. The circuit module has a first substrate, a first die coupled to the first substrate, a second die, and a second substrate coupled to and disposed between the first die and the second die. The second substrate has a first plurality of conductors to carry electrical signals to and from the first die and a second plurality of conductors to carry electrical signals to and from the second die. The die may be any of a number of types of electronic components, such as power transistors, memory chips, or others. The stacking of the die saves board space, allowing for further miniaturization or incorporation of additional electronic components.
摘要翻译： 提供可植入的心脏除颤器。 可植入心脏除颤器包括罐，用于为去纤颤器供电的存储单元，以及设置在罐中的用于控制除颤器的电路模块。 电路模块具有第一基板，耦合到第一基板的第一管芯，第二管芯和耦合到第一管芯和第二管芯之间的第二基板。 第二衬底具有第一多个导体，用于将电信号传送到第一管芯和从第一管芯传送电信号，以及第二多个导体，以将电信号传送到第二管芯和从第二管芯传送电信号。 芯片可以是许多类型的电子部件中的任何一种，诸如功率晶体管，存储芯片等。 模具的堆叠可节省电路板空间，从而进一步小型化或并入额外的电子元件。
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公开(公告)号：US09700565B2
公开(公告)日：2017-07-11
申请号：US14928223
申请日：2015-10-30
IPC分类号： A61K31/553
CPC分类号： A61K31/553
摘要： The present invention relates to a method of treating a warm-blooded animal, especially a human, having Mixed Lineage Leukemia (MLL rearranged ALL) comprising administering to said animal a therapeutically effective amount of a staurosporine derivative, especially PKC412 or a pharmaceutically acceptable salt thereof, alone or in combination with further therapeutic measures, for example, those defined herein; to the use of a staurosporine derivative for the preparation of a medicament for the treatment of MLL rearranged ALL; and to a commercial package comprising a staurosporine derivative together with instructions for its use in the treatment of MLL rearranged ALL.
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公开(公告)号：US08165693B2
公开(公告)日：2012-04-24
申请号：US11186261
申请日：2005-07-21
IPC分类号： A61N1/00
CPC分类号： A61N1/36082 , A61N1/36114 , A61N1/36142 , A61N1/36146 , A61N1/3718
摘要： A method, system, and apparatus for implementing a safe mode operation of an implantable medical system using impedance adjustment(s) are provided. A first impedance is provided to a lead. An indication of a possibility of a coupled energy is received. Based upon said indication, a second impedance associated with the lead to reduce the coupled energy is provided.
摘要翻译： 提供了一种用于实现使用阻抗调节的可植入医疗系统的安全模式操作的方法，系统和装置。 向引线提供第一阻抗。 接收到耦合能量的可能性的指示。 基于所述指示，提供与引线相关联的用于降低耦合能量的第二阻抗。
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公开(公告)号：US08140159B2
公开(公告)日：2012-03-20
申请号：US11186547
申请日：2005-07-21
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/36114 , A61N1/36142 , A61N1/36146 , A61N1/3718
摘要： A method, system, and apparatus for implementing a safe mode operation of an implantable medical system using impedance adjustment(s) are provided. A first impedance is provided to a lead. An indication of a possibility of a coupled energy is received. Based upon said indication, a second impedance associated with the lead to reduce the coupled energy is provided.
摘要翻译： 提供了一种用于实现使用阻抗调节的可植入医疗系统的安全模式操作的方法，系统和装置。 向引线提供第一阻抗。 接收到耦合能量的可能性的指示。 基于所述指示，提供与引线相关联的用于降低耦合能量的第二阻抗。
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公开(公告)号：US07899540B2
公开(公告)日：2011-03-01
申请号：US11118980
申请日：2005-04-29
IPC分类号： A61N1/36
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007
摘要： A method and apparatus for treatment of an eating disorder includes electrically stimulating the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. A device comprising a gastric band including stimulation electrodes may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. A programmable implantable stimulus generator may be operatively coupled to a nerve electrode. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译： 用于治疗进食障碍的方法和装置包括电刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导迷走神经的传入动作电位。 包括刺激电极的胃带的装置可以在植入后进行非侵入性调整，以对患者的胃肠道提供增加或减少的限制。 每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。 可编程植入式刺激发生器可以可操作地耦合到神经电极。 还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。
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