Removal and deactivation of viruses from blood
    1.
    发明授权
    Removal and deactivation of viruses from blood 失效
    从血液中去除和去除病毒

    公开(公告)号:US07753869B2

    公开(公告)日:2010-07-13

    申请号:US11739574

    申请日:2007-04-24

    摘要: A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50-75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.

    摘要翻译: 提供了一种预防和治疗患者血液中败血病的方法和装置。 体外系统包括用于灭活至少99%的血源性微生物的抗微生物装置,血液浓缩器/过滤单元以从患者血液中除去大约50-75%的靶分子,以及过滤器单元以从筛选的患者血液中除去靶分子 血浆滤液。 靶分子由微生物以及患者的细胞产生。 这些分子包括来自革兰氏阴性细菌的内毒素,来自革兰阴性和革兰氏阳性细菌的外毒素,以及来自金黄色葡萄球菌的RAP蛋白质介质,以及细胞介质如肿瘤坏死因子-α和白介素1-β,白细胞介素6,补体蛋白 C3a和C5a以及缓激肽。

    Apparatus and method for down-regulating immune system mediators in blood
    3.
    发明授权
    Apparatus and method for down-regulating immune system mediators in blood 失效
    用于下调血液中免疫系统介质的装置和方法

    公开(公告)号:US07207964B2

    公开(公告)日:2007-04-24

    申请号:US10390558

    申请日:2003-03-17

    摘要: A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50–75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.

    摘要翻译: 提供了一种预防和治疗患者血液中败血症的方法和装置。 体外系统包括用于灭活至少99%的血源性微生物的抗微生物装置,血液浓缩器/过滤单元以从患者血液中除去大约50-75%的靶分子,以及过滤器单元以从筛选的患者血液中除去靶分子 血浆滤液。 靶分子由微生物以及患者的细胞产生。 这些分子包括来自革兰氏阴性细菌的内毒素,来自革兰阴性和革兰氏阳性细菌的外毒素,以及来自金黄色葡萄球菌的RAP蛋白质介质,以及细胞介质如肿瘤坏死因子-α和白介素1-β,白细胞介素6,补体蛋白 C3a和C5a以及缓激肽。

    Device and method for reducing inflammatory mediators in blood
    4.
    发明授权
    Device and method for reducing inflammatory mediators in blood 失效
    用于减少血液中炎症介质的装置和方法

    公开(公告)号:US07201730B2

    公开(公告)日:2007-04-10

    申请号:US10391443

    申请日:2003-03-17

    摘要: A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50–75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.

    摘要翻译: 提供了一种预防和治疗患者血液中败血症的方法和装置。 体外系统包括用于灭活至少99%的血源性微生物的抗微生物装置,血液浓缩器/过滤单元以从患者血液中除去大约50-75%的靶分子,以及过滤器单元以从筛选的患者血液中除去靶分子 血浆滤液。 靶分子由微生物以及患者的细胞产生。 这些分子包括来自革兰氏阴性细菌的内毒素,来自革兰阴性和革兰氏阳性细菌的外毒素,以及来自金黄色葡萄球菌的RAP蛋白质介质,以及细胞介质如肿瘤坏死因子-α和白介素1-β,白细胞介素6,补体蛋白 C3a和C5a以及缓激肽。

    Irradiation and filter device for treatment of blood
    10.
    发明授权
    Irradiation and filter device for treatment of blood 失效
    用于治疗血液的照射和过滤装置

    公开(公告)号:US07229427B2

    公开(公告)日:2007-06-12

    申请号:US10390572

    申请日:2003-03-17

    IPC分类号: A61M37/00 A61M5/00

    摘要: A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50–75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.

    摘要翻译: 提供了一种预防和治疗患者血液中败血症的方法和装置。 体外系统包括用于灭活至少99%的血源性微生物的抗微生物装置,血液浓缩器/过滤单元以从患者血液中除去大约50-75%的靶分子,以及过滤器单元以从筛选的患者血液中除去靶分子 血浆滤液。 靶分子由微生物以及患者的细胞产生。 这些分子包括来自革兰氏阴性细菌的内毒素,来自革兰阴性和革兰氏阳性细菌的外毒素,以及来自金黄色葡萄球菌的RAP蛋白质介质,以及细胞介质如肿瘤坏死因子-α和白介素1-β,白细胞介素6,补体蛋白 C3a和C5a以及缓激肽。