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1.发明授权Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and their use in bioassays 有权羟基化的1,2,4-恶二唑苯甲酸化合物，其组合物及其在生物测定中的用途公开(公告)号：US08691511B2
公开(公告)日：2014-04-08
申请号：US13327816
申请日：2011-12-16
IPC分类号： C12Q1/68 , C07D271/06 , A61K31/41 , C12P21/04
CPC分类号： A61K31/4245 , C07D271/06
摘要： Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新型羟基化的1,2,4-恶二唑苯甲酸化合物，使用方法和包含羟基化的1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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公开(公告)号：US08486982B2
公开(公告)日：2013-07-16
申请号：US13530139
申请日：2012-06-22
申请人： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
发明人： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
IPC分类号： C07D271/06 , A61K31/4245
CPC分类号： A61K31/4245 , A61K9/0053 , A61K9/12 , A61K9/48 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/655 , A61K45/06 , A61P27/02 , C07D271/06 , C07D271/12 , C07D285/14 , C07D413/02 , C07D413/04 , C07D413/10
摘要： Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新的1,2,4-恶二唑苯甲酸化合物，使用方法和包含1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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3.发明授权Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease 有权脲基取代的苯甲酸化合物及其用于无意义抑制和治疗疾病的用途公开(公告)号：US08334313B2
公开(公告)日：2012-12-18
申请号：US12980495
申请日：2010-12-29
IPC分类号： A61K31/415 , C07D233/00
CPC分类号： C07D285/16 , A61K31/17 , A61K31/4166 , A61K31/4172 , A61K31/4196 , A61K31/421 , A61K31/426 , C07C275/42 , C07D233/32 , C07D233/42 , C07D233/72 , C07D401/04 , C07D401/10 , C07D405/04 , C07D405/06 , C07D409/04
摘要： The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
摘要翻译： 本发明包括脲基取代的苯甲酸化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
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4.发明申请公开(公告)号：US20120178080A1
公开(公告)日：2012-07-12
申请号：US13427932
申请日：2012-03-23
申请人： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
发明人： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
IPC分类号： C12Q1/68
CPC分类号： C07D285/14 , C07D413/02
摘要： Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新的1,2,4-恶二唑苯甲酸化合物，使用方法和包含1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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![CRYSTALLINE FORMS OF 3-[5-(2-FLUOROPHENYL)-[1,2,4]OXADIAZOL-3-YL]-BENZOIC ACID](/abs-image/US/2011/02/17/US20110040100A1/abs.jpg.150x150.jpg)
5.发明申请CRYSTALLINE FORMS OF 3-[5-(2-FLUOROPHENYL)-[1,2,4]OXADIAZOL-3-YL]-BENZOIC ACID 有权3- [5-（2-氟 - 戊基） - [1,2,4]氧杂双环[3-y]] - 苯甲酸的晶体形式公开(公告)号：US20110040100A1
公开(公告)日：2011-02-17
申请号：US12913213
申请日：2010-10-27
IPC分类号： C07D271/06
CPC分类号： A61K31/4245 , C07D271/06
摘要： The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay.
摘要翻译： 本发明涉及3- [5-（2-氟苯基） - [1,2,4]恶二唑-3-基] - 苯甲酸的结晶形式，包含结晶形式的药物组合物和剂型， 它们用于治疗，预防或控制通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病的结晶形式和方法。
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![Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-YL]-benzoic acid](/abs-image/US/2011/01/04/US07863456B2/abs.jpg.150x150.jpg)
6.发明授权Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-YL]-benzoic acid 有权结晶形式的3- [5-（2-氟苯基） - [1,2,4]恶二唑-3-基] - 苯甲酸公开(公告)号：US07863456B2
公开(公告)日：2011-01-04
申请号：US11904005
申请日：2007-09-24
IPC分类号： C07D271/06
CPC分类号： A61K31/4245 , C07D271/06
摘要： The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay.
摘要翻译： 本发明涉及3- [5-（2-氟苯基） - [1,2,4]恶二唑-3-基] - 苯甲酸的结晶形式，包含结晶形式的药物组合物和剂型， 它们用于治疗，预防或控制通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病的结晶形式和方法。
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7.发明授权Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease 有权脲基取代的苯甲酸化合物及其用于无意义抑制和治疗疾病的用途公开(公告)号：US07405233B2
公开(公告)日：2008-07-29
申请号：US11048656
申请日：2005-01-21
IPC分类号： A61K31/415
CPC分类号： C07D285/16 , A61K31/17 , A61K31/4166 , A61K31/4172 , A61K31/4196 , A61K31/421 , A61K31/426 , C07C275/42 , C07D233/32 , C07D233/42 , C07D233/72 , C07D401/04 , C07D401/10 , C07D405/04 , C07D405/06 , C07D409/04
摘要： The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
摘要翻译： 本发明包括脲基取代的苯甲酸化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
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8.发明申请1,2,4-Oxadiazole benzoic acid compositions and their use for nonsense suppression and the treatment of disease 失效1,2,4-恶二唑苯甲酸组合物及其用于无义抑制和疾病治疗的用途公开(公告)号：US20070161687A1
公开(公告)日：2007-07-12
申请号：US11724408
申请日：2007-03-14
申请人： Gary Karp , Seongwoo Hwang , Guangming Chen , Neil Almstead , Young-Choon Moon
发明人： Gary Karp , Seongwoo Hwang , Guangming Chen , Neil Almstead , Young-Choon Moon
IPC分类号： A61K31/4245
CPC分类号： A61K31/4245 , A61K9/0053 , A61K9/12 , A61K9/48 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/655 , A61K45/06 , A61P27/02 , C07D271/06 , C07D271/12 , C07D285/14 , C07D413/02 , C07D413/04 , C07D413/10
摘要： Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新的1,2,4-恶二唑苯甲酸化合物，使用方法和包含1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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9.发明申请1,2,4-Oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease 有权1,2,4-恶二唑苯甲酸化合物及其用于无味抑制和治疗疾病的用途公开(公告)号：US20060035943A1
公开(公告)日：2006-02-16
申请号：US11241700
申请日：2005-09-29
申请人： Gary Karp , Seongwoo Hwang , Guangming Chen , Neil Almstead , Young-Choon Moon
发明人： Gary Karp , Seongwoo Hwang , Guangming Chen , Neil Almstead , Young-Choon Moon
IPC分类号： C07D271/06 , A61K31/4245
CPC分类号： A61K31/4245 , A61K9/0053 , A61K9/12 , A61K9/48 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/655 , A61K45/06 , A61P27/02 , C07D271/06 , C07D271/12 , C07D285/14 , C07D413/02 , C07D413/04 , C07D413/10
摘要： Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新的1,2,4-恶二唑苯甲酸化合物，使用方法和包含1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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10.发明授权Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith 有权从具有无义突变的DNA生产功能性蛋白质的方法以及与其相关的病症的治疗公开(公告)号：US09289398B2
公开(公告)日：2016-03-22
申请号：US12294952
申请日：2007-03-29
申请人： Neil Almstead , Guangming Chen , Samit Hirawat , Peter Seongwoo Hwang , Gary M. Karp , Langdon Miller , Young-Choon Moon , Hongyu Ren , James J. Takasugi , Ellen M. Welch , Richard G. Wilde , Paul Kennedy
发明人： Neil Almstead , Guangming Chen , Samit Hirawat , Peter Seongwoo Hwang , Gary M. Karp , Langdon Miller , Young-Choon Moon , Hongyu Ren , James J. Takasugi , Ellen M. Welch , Richard G. Wilde , Paul Kennedy
IPC分类号： A61K31/4245 , A61P21/00 , A61K31/00 , A61K31/40 , A61K31/41 , A61K31/4162 , A61K31/44 , A61K31/46 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/4439 , A61K31/519 , A61K31/498 , A61K31/53 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/433 , A61K31/421 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/42 , A61K31/4164 , A61K31/34 , A61K31/381 , A61K31/4196 , A61P11/00 , A61P7/00 , A61P25/00 , A61P13/12 , A61P27/02
CPC分类号： A61K31/4245 , A61K31/00 , A61K31/40 , A61K31/41 , A61K31/4162 , A61K31/44 , A61K31/46
摘要： The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.
摘要翻译： 本发明涉及由包含无义突变的核酸序列编码的功能性蛋白质。 本发明还涉及用于产生由包含无义突变的核酸序列编码的功能性蛋白质的方法以及用于预防，管理和/或治疗与基因中的无义突变有关的疾病的这些蛋白质的用途。
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