METHODS FOR TREATING NEUROPSYCHIATRIC CONDITIONS
    1.
    发明申请
    METHODS FOR TREATING NEUROPSYCHIATRIC CONDITIONS 审中-公开
    治疗神经病学症状的方法

    公开(公告)号:US20100317715A1

    公开(公告)日:2010-12-16

    申请号:US12745886

    申请日:2008-12-19

    IPC分类号: A61K31/713 A61P25/00

    摘要: Provided herein are compositions and methods for treating a subject suffering from Fragile X syndrome, autism, Down's syndrome, mental retardation, or a neuropsychiatric condition (e.g., schizophrenia). The methods include systemic administration of a a therapeutically effective amount of a PAK inhibitor in combination with a Group I mGluR antagonist (e.g., an mGluR5 antagonist). The PAK inhibitor and mGluR antagonist can be administered together, e.g., in one pharmacological composition, or they can be administered separately.

    摘要翻译: 本文提供了用于治疗患有脆性X综合征,自闭症,唐氏综合征,精神发育迟滞或神经精神病状(例如精神分裂症)的受试者的组合物和方法。 所述方法包括联合治疗有效量的PAK抑制剂与I组mGluR拮抗剂(例如,mGluR5拮抗剂)的全身施用。 PAK抑制剂和mGluR拮抗剂可以一起施用,例如在一种药理组合物中,或者它们可以分开施用。