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    Magnetic separation device for cell sorting and analysis
    3.
    发明授权
    Magnetic separation device for cell sorting and analysis 有权
    用于细胞分选和分析的磁选机

    公开(公告)号：US08481336B2

    公开(公告)日：2013-07-09

    申请号：US12807625

    申请日：2010-09-09

    Applicant: Christopher M. Earhart ,  Shan X. Wang ,  Robert J. Wilson

    Inventor： Christopher M. Earhart ,  Shan X. Wang ,  Robert J. Wilson

    IPC: G01N33/553 ,  B01D63/00

    CPC classification number: C12N13/00 ,  G01N33/54333 ,  G01N33/56966 ,  G01N33/57488

    Abstract: A magnetic sifter is adapted for manipulation of biological cells by providing a greater pore density at the edge of the sifter than at the center. Application of an external magnetic field to the sifter causes high magnetic fields and field gradients at the sifter pores. These conditions are suitable for capturing magnetically tagged or labeled cells at the sifter pores. Altering the external magnetic field can provide controlled capture and/or release of magnetically labeled cells from the sifter pores. The purpose of having a greater pore density at the periphery of the sifter than at the center is to provide improved flow rate uniformity through the sifter. Such flow rate uniformity is advantageous for cell quantification.

    Abstract translation: 磁选机适用于通过在筛子的边缘处提供比在中心处更大的孔密度来操纵生物细胞。 在筛子上施加外部磁场会在筛分孔产生高磁场和场梯度。 这些条件适用于在筛子孔处捕获磁标记或标记的细胞。 改变外部磁场可以提供来自筛子孔的磁性标记细胞的受控捕获和/或释放。 在筛子周边具有比中心更大的孔密度的目的是通过筛子提供改善的流速均匀性。 这样的流速均匀性对于细胞定量是有利的。

    Temperature and drift compensation in magnetoresistive sensors
    4.
    发明申请
    Temperature and drift compensation in magnetoresistive sensors 有权
    磁阻传感器的温度和漂移补偿

    公开(公告)号：US20100231203A1

    公开(公告)日：2010-09-16

    申请号：US12661158

    申请日：2010-03-10

    Applicant: Drew A. Hall ,  Richard Gaster ,  Sebastian J. Osterfeld ,  Shan X. Wang

    Inventor： Drew A. Hall ,  Richard Gaster ,  Sebastian J. Osterfeld ,  Shan X. Wang

    IPC: G01R35/00 ,  G01R33/18

    CPC classification number: G01R33/1269 ,  B82Y25/00 ,  G01R33/09 ,  G01R33/093

    Abstract: Double modulation of a magnetoresistive sensor entails modulating both an excitation (e.g., voltage or current) applied to the sensor and a tickling magnetic field applied to the sensor. The excitation and magnetic field are modulated at different frequencies fc and ff, respectively. As a result of the double modulation, the sensor output spectrum includes a carrier tone (CT) at frequency fc and side tones (STs) at frequencies fc±ff. A baseline relation between CT amplitude and ST amplitude is determined (e.g., by measuring CT and ST amplitude while drift occurs in the absence of a sample). During sensor operation, raw ST measurements are corrected using corresponding raw CT measurements to provide corrected ST measurements as the sensor output.

    Abstract translation: 磁阻传感器的双重调制需要调制施加到传感器的激励（例如，电压或电流）以及施加到传感器的挠曲磁场。 励磁和磁场分别以不同频率fc和ff进行调制。 作为双调制的结果，传感器输出频谱包括频率为fc的载波音（CT）和频率fc±ff的侧音（ST）。 确定CT幅度和ST幅度之间的基线关系（例如，通过测量CT和ST振幅，而在不存在样本的情况下发生漂移）。 在传感器操作期间，使用相应的原始CT测量来校正原始ST测量值，以提供校正的ST测量作为传感器输出。

    DUMBBELL-LIKE NANOPARTICLES AND A PROCESS OF FORMING THE SAME
    6.
    发明申请
    DUMBBELL-LIKE NANOPARTICLES AND A PROCESS OF FORMING THE SAME 失效
    类似纳米粒子的纳米颗粒及其形成方法

    公开(公告)号：US20080168863A1

    公开(公告)日：2008-07-17

    申请号：US11830870

    申请日：2007-07-31

    Applicant: Shouheng Sun ,  Heng Yu ,  Shan X. Wang

    Inventor： Shouheng Sun ,  Heng Yu ,  Shan X. Wang

    IPC: B22F9/16

    CPC classification number: C01G1/00 ,  B22F1/0022 ,  B22F1/0096 ,  B22F2999/00 ,  B82Y25/00 ,  B82Y30/00 ,  C01B17/20 ,  C01B19/007 ,  C01P2002/72 ,  C01P2002/84 ,  C01P2004/04 ,  C01P2004/30 ,  C01P2004/64 ,  C01P2004/80 ,  C01P2006/42 ,  C09C3/063 ,  H01F1/0054 ,  Y10S977/835 ,  B22F1/0018

    Abstract: Dumbbell-shaped or flower-shaped nanoparticles and a process of forming the same, wherein the process comprises forming a mixture of a nanoparticle with a precursor in a first solvent, wherein the nanoparticle comprises a hydrophobic outer coating; heating the mixture; cooling the mixture to room temperature; modifying the hydrophobic outer coating into a hydrophilic outer coating; precipitating a solid product from the mixture, and dispersing the product in a second solvent. The nanoparticles comprise any of a semiconducting, magnetic, and noble metallic material, wherein the nanoparticles comprise a first portion comprising any of PbSe, PbS, CdSe, CdS, ZnS, Au, Ag, Pd, and Pt, and wherein the precursor comprises any of a cationic, neutral or particulate Au, Ag, Pd, Pt, or transition metal (Fe, Co, Ni) precursors of Fe(CO)5, Co(CO)8, Ni(CO)4 or their analogues. The first and second solvents comprise any of alkanes, arenes, ethers, nitrites, ketones, and chlorinated hydrocarbons.

    Abstract translation: 哑铃形或花形纳米颗粒及其形成方法，其中所述方法包括在第一溶剂中形成纳米颗粒与前体的混合物，其中所述纳米颗粒包含疏水外涂层; 加热混合物; 将混合物冷却至室温; 将疏水性外涂层改性为亲水性外涂层; 从混合物中沉淀出固体产物，并将产物分散在第二溶剂中。 纳米颗粒包括半导体，磁性和贵金属材料中的任何一种，其中纳米颗粒包括包含PbSe，PbS，CdSe，CdS，ZnS，Au，Ag，Pd和Pt中的任何一种的第一部分，并且其中前体包含任何 的阳离子，中性或微粒Au，Ag，Pd，Pt或过渡金属（Fe，Co，Ni）前体Fe（CO）5，Co（CO） （CO）4或它们的类似物。 第一和第二溶剂包括任何烷烃，芳烃，醚，亚硝酸盐，酮和氯代烃。

    Dumbbell-like nanoparticles and a process of forming the same
    7.
    发明授权
    Dumbbell-like nanoparticles and a process of forming the same 失效
    哑铃状纳米颗粒及其形成方法

    公开(公告)号：US07288134B2

    公开(公告)日：2007-10-30

    申请号：US10938897

    申请日：2004-09-10

    Applicant: Shouheng Sun ,  Heng Yu ,  Shan X. Wang

    Inventor： Shouheng Sun ,  Heng Yu ,  Shan X. Wang

    IPC: B22F1/02

    CPC classification number: C01G1/00 ,  B22F1/0022 ,  B22F1/0096 ,  B22F2999/00 ,  B82Y25/00 ,  B82Y30/00 ,  C01B17/20 ,  C01B19/007 ,  C01P2002/72 ,  C01P2002/84 ,  C01P2004/04 ,  C01P2004/30 ,  C01P2004/64 ,  C01P2004/80 ,  C01P2006/42 ,  C09C3/063 ,  H01F1/0054 ,  Y10S977/835 ,  B22F1/0018

    Abstract: Dumbbell-shaped or flower-shaped nanoparticles and a process of forming the same, wherein the process comprises forming a mixture of a nanoparticle with a precursor in a first solvent, wherein the nanoparticle comprises a hydrophobic outer coating; heating the mixture; cooling the mixture to room temperature; modifying the hydrophobic outer coating into a hydrophilic outer coating; precipitating a solid product from the mixture, and dispersing the product in a second solvent. The nanoparticles comprise any of a semiconducting, magnetic, and noble metallic material, wherein the nanoparticles comprise a first portion comprising any of PbSe, PbS, CdSe, CdS, ZnS, Au, Ag, Pd, and Pt, and wherein the precursor comprises any of a cationic, neutral or particulate Au, Ag, Pd, Pt, or transition metal (Fe, Co, Ni) precursors of Fe(CO)5, Co(CO)8, Ni(CO)4 or their analogues. The first and second solvents comprise any of alkanes, arenes, ethers, nitrites, ketones, and chlorinated hydrocarbons.

    Abstract translation: 哑铃形或花形纳米颗粒及其形成方法，其中所述方法包括在第一溶剂中形成纳米颗粒与前体的混合物，其中所述纳米颗粒包含疏水性外涂层; 加热混合物; 将混合物冷却至室温; 将疏水性外涂层改性为亲水性外涂层; 从混合物中沉淀出固体产物，并将产物分散在第二溶剂中。 纳米颗粒包括半导体，磁性和贵金属材料中的任何一种，其中纳米颗粒包括包含PbSe，PbS，CdSe，CdS，ZnS，Au，Ag，Pd和Pt中的任何一种的第一部分，并且其中前体包含任何 的阳离子，中性或微粒Au，Ag，Pd，Pt或过渡金属（Fe，Co，Ni）前体Fe（CO）5，Co（CO） （CO）4或它们的类似物。 第一和第二溶剂包括任何烷烃，芳烃，醚，亚硝酸盐，酮和氯代烃。

    Methods and devices for detecting the presence of an analyte in a sample
    8.
    发明授权
    Methods and devices for detecting the presence of an analyte in a sample 有权
    用于检测样品中分析物的存在的方法和装置

    公开(公告)号：US09506919B2

    公开(公告)日：2016-11-29

    申请号：US12759584

    申请日：2010-04-13

    Applicant: Richard Samuel Gaster ,  Drew Hall ,  Shan X. Wang

    Inventor： Richard Samuel Gaster ,  Drew Hall ,  Shan X. Wang

    IPC: G01N33/543 ,  G01N27/74 ,  G01N33/574 ,  G01N21/552 ,  G01N21/64 ,  G01N21/65

    CPC classification number: G01N33/54373 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/658 ,  G01N27/745 ,  G01N33/574 ,  G01N2201/0221 ,  Y10T436/25

    Abstract: Sensor assay methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include providing a sensor, e.g., a proximity sensor, in contact with an assay composition that includes a sample and a proximity label. Next, a capture probe configured to bind to the proximity label and the analyte is introduced into the assay composition to produce a labeled analyte. Following capture probe introduction, a signal is obtained from the sensor to detect the presence of the labeled analyte in the sample. Also provided are sensor devices, including hand-held devices, and kits that find use in practicing the subject methods.

    Abstract translation: 提供了用于检测样品中分析物的存在的传感器测定方法。 方法的方面包括提供与包括样品和接近标签的测定组合物接触的传感器，例如接近传感器。 接下来，将配置成与邻近标签和分析物结合的捕获探针引入测定组合物中以产生标记的分析物。 在捕获探针引入后，从传感器获得信号以检测样品中标记分析物的存在。 还提供了用于实践主题方法的传感器装置，包括手持装置和试剂盒。

    Temperature and drift compensation in magnetoresistive sensors
    9.
    发明授权
    Temperature and drift compensation in magnetoresistive sensors 有权
    磁阻传感器的温度和漂移补偿

    公开(公告)号：US08405385B2

    公开(公告)日：2013-03-26

    申请号：US12661158

    申请日：2010-03-10

    Applicant: Drew A. Hall ,  Richard Gaster ,  Sebastian J. Osterfeld ,  Shan X. Wang

    Inventor： Drew A. Hall ,  Richard Gaster ,  Sebastian J. Osterfeld ,  Shan X. Wang

    IPC: G01B7/14 ,  G01R35/00

    CPC classification number: G01R33/1269 ,  B82Y25/00 ,  G01R33/09 ,  G01R33/093

    Abstract: Double modulation of a magnetoresistive sensor entails modulating both an excitation (e.g., voltage or current) applied to the sensor and a tickling magnetic field applied to the sensor. The excitation and magnetic field are modulated at different frequencies fc and ff, respectively. As a result of the double modulation, the sensor output spectrum includes a carrier tone (CT) at frequency fc and side tones (STs) at frequencies fc±ff. A baseline relation between CT amplitude and ST amplitude is determined (e.g., by measuring CT and ST amplitude while drift occurs in the absence of a sample). During sensor operation, raw ST measurements are corrected using corresponding raw CT measurements to provide corrected ST measurements as the sensor output.

    Abstract translation: 磁阻传感器的双重调制需要调制施加到传感器的激励（例如，电压或电流）以及施加到传感器的挠曲磁场。 励磁和磁场分别以不同频率fc和ff进行调制。 作为双调制的结果，传感器输出频谱包括频率为fc的载波音（CT）和频率fc±ff的侧音（ST）。 确定CT幅度和ST幅度之间的基线关系（例如，通过测量CT和ST振幅，而在不存在样本的情况下发生漂移）。 在传感器操作期间，使用相应的原始CT测量来校正原始ST测量值，以提供校正的ST测量作为传感器输出。

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