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公开(公告)号：US20090075881A1
公开(公告)日：2009-03-19
申请号：US12142734
申请日：2008-06-19
CPC分类号： A61K38/1858 , A61L24/0015 , A61L24/106 , A61L2300/414
摘要： The present invention relates, in general, to fibrin sealants, which contain platelet derived growth factor (PDGF) for controlled release in situ for therapeutic applications, including musculoskeletal disorders, soft tissue disorders and vascular diseases.
摘要翻译： 本发明一般涉及含有血小板衍生生长因子（PDGF）的纤维蛋白封闭剂，用于治疗应用的包括肌肉骨骼疾病，软组织疾病和血管疾病在内的控制释放。
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公开(公告)号：US08377864B2
公开(公告)日：2013-02-19
申请号：US12142734
申请日：2008-06-19
IPC分类号： A61K38/00 , A61K38/18 , A61K38/43 , A61K38/48 , A61P17/02 , A61K35/14 , C07K1/00 , C07K17/00
CPC分类号： A61K38/1858 , A61L24/0015 , A61L24/106 , A61L2300/414
摘要： The present invention relates, in general, to fibrin sealants, which contain platelet derived growth factor (PDGF) for controlled release in situ for therapeutic applications, including musculoskeletal disorders, soft tissue disorders and vascular diseases.
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3.发明申请公开(公告)号：US20110200577A1
公开(公告)日：2011-08-18
申请号：US12987531
申请日：2011-01-10
申请人： Stephen L. Smith , Loredana Campo , Jennifer Campbell , Shiri Uriel Wallach , Wanda Seyton , Shane Donovan
发明人： Stephen L. Smith , Loredana Campo , Jennifer Campbell , Shiri Uriel Wallach , Wanda Seyton , Shane Donovan
CPC分类号： A61K38/18 , A61K38/195 , A61K38/363 , A61K38/4833 , A61L24/0015 , A61L24/106 , A61L2300/252 , A61K38/00
摘要： The invention relates to a pharmaceutical composition which comprises a fibrin clot and a cytokine and methods of delivering the composition to a site of disease or injury in vivo to attract and retain regenerative or reparative stem or myeloid cells and their differentiated progeny.
摘要翻译： 本发明涉及一种药物组合物，其包含纤维蛋白凝块和细胞因子以及将组合物递送至体内疾病或损伤部位以吸引和保留再生或修复性干细胞或骨髓细胞及其分化后代的方法。
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公开(公告)号：US07767647B2
公开(公告)日：2010-08-03
申请号：US12221086
申请日：2008-07-30
申请人： Shane Donovan , Donald Baker
发明人： Shane Donovan , Donald Baker
IPC分类号： A61K38/00
CPC分类号： A61K38/36 , A61K38/4846
摘要： The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity, thus reducing the incidence of undesired side effects in a subject.
摘要翻译： 本发明提供了通过施用富含因子IXa的制剂来治疗受试者的出血性疾病的方法。 因子IXa可以通过蛋白水解激活重组产生的因子IX产生。 本发明还提供了用于从血浆部分制备因子IXa的改进方法，该方法产生含有很少或不具有前激肽释放酶活性的因子IXa产物，从而降低受试者中不期望的副作用的发生率。
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公开(公告)号：US20090069543A1
公开(公告)日：2009-03-12
申请号：US12221086
申请日：2008-07-30
申请人： Shane Donovan , Donald Baker
发明人： Shane Donovan , Donald Baker
IPC分类号： C07K14/745
CPC分类号： A61K38/36 , A61K38/4846
摘要： The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity, thus reducing the incidence of undesired side effects in a subject.
摘要翻译： 本发明提供了通过施用富含因子IXa的制剂来治疗受试者的出血性疾病的方法。 因子IXa可以通过蛋白水解激活重组产生的因子IX产生。 本发明还提供了用于从血浆部分制备因子IXa的改进方法，该方法产生含有很少或不具有前激肽释放酶活性的因子IXa产物，从而降低受试者中不期望的副作用的发生率。
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公开(公告)号：US20050209149A1
公开(公告)日：2005-09-22
申请号：US11068596
申请日：2005-02-28
申请人： Shane Donovan , Donald Baker
发明人： Shane Donovan , Donald Baker
CPC分类号： A61K38/36 , A61K38/4846
摘要： The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity, thus reducing the incidence of undesired side effects in a subject.
摘要翻译： 本发明提供了通过施用富含因子IXa的制剂来治疗受试者的出血性疾病的方法。 因子IXa可以通过蛋白水解激活重组产生的因子IX产生。 本发明还提供了用于从血浆部分制备因子IXa的改进方法，该方法产生含有很少或不具有前激肽释放酶活性的因子IXa产物，从而降低受试者中不期望的副作用的发生率。
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公开(公告)号：US07425539B2
公开(公告)日：2008-09-16
申请号：US11068596
申请日：2005-02-28
申请人： Shane Donovan , Donald A. Baker
发明人： Shane Donovan , Donald A. Baker
IPC分类号： A61K38/00
CPC分类号： A61K38/36 , A61K38/4846
摘要： The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity, thus reducing the incidence of undesired side effects in a subject.
摘要翻译： 本发明提供了通过施用富含因子IXa的制剂来治疗受试者的出血性疾病的方法。 因子IXa可以通过蛋白水解激活重组产生的因子IX产生。 本发明还提供了用于从血浆部分制备因子IXa的改进方法，该方法产生含有很少或不具有前激肽释放酶活性的因子IXa产物，从而降低受试者中不期望的副作用的发生率。
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