公开(公告)号：US09333287B2

公开(公告)日：2016-05-10

申请号：US12923796

申请日：2010-10-07

申请人： David Nitsan ,  Shay Dubi ,  Nadav Ben-Da'At ,  Anat Kerem-Angel ,  Jacek Krzyzanowski

发明人： David Nitsan ,  Shay Dubi ,  Nadav Ben-Da'At ,  Anat Kerem-Angel ,  Jacek Krzyzanowski

IPC分类号： A61M31/00 ,  A61M3/02 ,  A61B1/00 ,  A61M1/00 ,  A61B1/12

CPC分类号： A61M3/0283 ,  A61B1/00068 ,  A61B1/12 ,  A61M1/0064 ,  A61M3/0295

摘要： The present invention provides a body passage cleansing device suitable for being passed through an internal channel of an endoscope, comprising a distal plug having a proximal end and a distal end, wherein said plug comprises channels, apertures and/or nozzles which are capable of allowing the passage of a fluid therethrough from said proximal end to said distal end, wherein said plug is connected to the distal end of a wire or other actuating means; wherein at least an outer portion of said distal plug is capable of being elastically deformed such that the external diameter and/or outline thereof may be reduced in response to inwardly-directed compression forces exerted thereon; and wherein said channels, apertures and/or nozzles are in a closed conformation when said distal plug is subject to said compression forces, and in an open conformation when said plug is not subject to said compression forces.

摘要翻译： 本发明提供一种适于穿过内窥镜的内部通道的身体通道清洁装置，其包括具有近端和远端的远侧塞子，其中所述塞子包括能够允许的通道，孔和/或喷嘴 流体从所述近端通过所述远端，其中所述塞子连接到电线或其它致动装置的远端; 其中所述远端塞的至少外部部分能够弹性变形，使得其外径和/或轮廓可以响应于施加在其上的向内定向的压缩力而减小; 并且其中当所述远端塞受到所述压缩力时，所述通道，孔和/或喷嘴处于闭合构型，并且当所述塞不受所述压缩力时处于开放构型。

公开(公告)号：US08894680B2

公开(公告)日：2014-11-25

申请号：US12083436

申请日：2006-10-13

申请人： Eran Hirszowicz ,  Shay Dubi

发明人： Eran Hirszowicz ,  Shay Dubi

IPC分类号： A61M25/10 ,  A61M25/01

CPC分类号： A61M25/1006 ,  A61M25/0119 ,  A61M25/104 ,  A61M2025/0183 ,  A61M2025/1015 ,  A61M2025/1068 ,  A61M2025/109

摘要： The present invention is primarily directed to a rapid exchange catheter that permits axial movement of an inner conduit within an outer conduit comprising: • an outer conduit; • an inner conduit, suitable for total or partial passage over a guide wire, wherein said inner conduit is movably disposed within the lumen of said outer conduit, wherein the proximal end of said inner conduit is angled such that it pierces the wall of said outer conduit; • means for permitting axial movement of said inner conduit within said outer conduit, such that said movement is not hindered by the passage of the angled proximal part of the inner conduit through said outer conduit; and • means, situated at the proximal end of the outer conduit, for causing axial pushing-pulling movements of said inner conduit.

摘要翻译： 本发明主要涉及一种快速交换导管，其允许内导管在外导管内的轴向移动，包括：外导管; •内导管，适于在导线上全部或部分通过，其中所述内导管可移动地设置在所述外导管的内腔中，其中所述内导管的近端成角度，使得其穿透所述外导管的壁 导管; •用于允许所述内部管道在所述外部管道内的轴向移动的装置，使得所述运动不受所述内部导管的成角度的近端部分通过所述外部导管的阻碍; 以及•装置，位于所述外导管的近端处，用于引起所述内导管的轴向推拉动作。

公开(公告)号：US20120253284A1

公开(公告)日：2012-10-04

申请号：US13439043

申请日：2012-04-04

申请人： David NITSAN ,  Shay DUBI

发明人： David NITSAN ,  Shay DUBI

IPC分类号： A61M37/00

CPC分类号： A61M3/0283 ,  A61B1/31

摘要： The present invention may provide devices suitable for insertion into a body passage. The devices may include a conduit and a distal head region located at the distal end of said conduit. A plurality of apertures on the surface of said head region and conduit may be used to direct a liquid spray outwards from said device. The apertures may be designed and spatially arranged such that when the device is inserted into a body passage, the liquid spray emitted from said apertures may be capable of both reducing the frictional contact between the device and the walls of said passage and of cleansing said passage of undesired solid and other particulate matter.

摘要翻译： 本发明可以提供适于插入身体通道的装置。 所述装置可以包括位于所述导管的远端处的导管和远侧头部区域。 所述头部区域和导管表面上的多个孔可用于将液体喷雾从所述装置向外引导。 孔可以被设计和空间地布置，使得当装置插入体通道中时，从所述孔排出的液体喷雾可能既能减少装置与所述通道的壁之间的摩擦接触，也可以清洁所述通道 的不期望的固体和其他颗粒物质。

公开(公告)号：US20120245608A1

公开(公告)日：2012-09-27

申请号：US13489187

申请日：2012-06-05

申请人： Eran Hirszowicz ,  Eran Levit ,  Shay Dubi

发明人： Eran Hirszowicz ,  Eran Levit ,  Shay Dubi

IPC分类号： A61B17/22

CPC分类号： A61M25/1006 ,  A61M25/0052 ,  A61M25/0054 ,  A61M25/0119 ,  A61M25/1002 ,  A61M25/104 ,  A61M2025/0183 ,  A61M2025/1065 ,  A61M2025/1068

摘要： The present invention provides a balloon catheter comprising: a hollow inner shaft disposed within a hollow outer shaft; a balloon attached at its proximal end to said outer shaft and at its distal end to said inner shaft; wherein the inner shaft is constructed such that following radial expansion of the balloon to a first expanded state, said inner shaft is capable of responding to further longitudinal expansion of the balloon to a second expanded state by increasing its length from a resting value, and of responding to subsequent partial deflation back to said first expanded state by reducing its length back to said resting value.

摘要翻译： 本发明提供一种球囊导管，包括：设置在中空外轴内的中空内轴; 在其近端处附接到所述外轴并且其远端附接到所述内轴的气囊; 其中所述内轴被构造成使得随着所述球囊的径向膨胀到第一膨胀状态，所述内轴能够通过从静止值增加其长度来响应气囊的进一步纵向膨胀到第二膨胀状态，并且 通过将其长度减小到所述静止值来响应随后的部分收缩回到所述第一扩张状态。

公开(公告)号：US20080071133A1

公开(公告)日：2008-03-20

申请号：US10577366

申请日：2004-10-28

申请人： Shay Dubi

发明人： Shay Dubi

IPC分类号： A61M1/10

CPC分类号： A61M1/107 ,  A61F2/2481 ,  A61M1/1008 ,  A61M1/1068 ,  A61M1/12

摘要： The present invention provides an anatomically-compatible and physiologically-compatible in vivo device for improving diastolic function of either the left or right ventricle of the heart, comprising at least one air-impermeable sheet that is capable of being operatively connected to the external ventricular surface of the heart by means of one or more connecting elements, such that said at least one air-impermeable sheet is capable of creating a sub-atmospheric pressure within said closed empty space as a consequence of changes in the volume of said space during the course of the cardiac cycle, thereby exerting an outward and normally directed force on the external ventricular surface of the heart.

摘要翻译： 本发明提供了一种用于改善心脏左心室或右心室舒张功能的解剖学兼容和生理相容的体内装置，其包括至少一个不透气片，其能够可操作地连接到外部心室表面 通过一个或多个连接元件的心脏，使得所述至少一个不透气片材能够在所述封闭的空的空间内产生作为所述空间的体积的变化的结果 的心脏周期，从而在心脏的外部心室表面上施加向外且正常定向的力。

公开(公告)号：US20070088380A1

公开(公告)日：2007-04-19

申请号：US11546571

申请日：2006-10-12

申请人： Eran Hirszowicz ,  Eran Levit ,  Shay Dubi

发明人： Eran Hirszowicz ,  Eran Levit ,  Shay Dubi

IPC分类号： A61M29/00

CPC分类号： A61M25/1006 ,  A61M25/0052 ,  A61M25/0054 ,  A61M25/0119 ,  A61M25/104 ,  A61M2025/0183 ,  A61M2025/1065 ,  A61M2025/1068

摘要： The present invention provides a balloon catheter comprising: a hollow inner shaft disposed within a hollow outer shaft; a balloon attached at its proximal end to said outer shaft and at its distal end to said inner shaft; wherein the inner shaft is constructed such that following radial expansion of the balloon to a first expanded state, said inner shaft is capable of responding to further longitudinal expansion of the balloon to a second expanded state by increasing its length from a resting value, and of responding to subsequent partial deflation back to said first expanded state by reducing its length back to said resting value.

摘要翻译： 本发明提供一种球囊导管，包括：设置在中空外轴内的中空内轴; 在其近端处附接到所述外轴并且其远端附接到所述内轴的气囊; 其中所述内轴被构造成使得随着所述球囊的径向膨胀到第一膨胀状态，所述内轴能够通过从静止值增加其长度来响应气囊的进一步纵向膨胀到第二膨胀状态，并且 通过将其长度减小到所述静止值来响应随后的部分收缩回到所述第一扩张状态。

公开(公告)号：US08652102B2

公开(公告)日：2014-02-18

申请号：US13439043

申请日：2012-04-04

申请人： David Nitsan ,  Shay Dubi

发明人： David Nitsan ,  Shay Dubi

IPC分类号： A61M37/00

CPC分类号： A61M3/0283 ,  A61B1/31

摘要： The present invention may provide devices suitable for insertion into a body passage. The devices may include a conduit and a distal head region located at the distal end of said conduit. A plurality of apertures on the surface of said head region and conduit may be used to direct a liquid spray outwards from said device. The apertures may be designed and spatially arranged such that when the device is inserted into a body passage, the liquid spray emitted from said apertures may be capable of both reducing the frictional contact between the device and the walls of said passage and of cleansing said passage of undesired solid and other particulate matter.

摘要翻译： 本发明可以提供适于插入身体通道的装置。 所述装置可以包括位于所述导管的远端处的导管和远侧头部区域。 所述头部区域和导管表面上的多个孔可用于将液体喷雾从所述装置向外引导。 孔可以被设计和空间地布置，使得当装置插入体通道中时，从所述孔排出的液体喷雾可能既能减少装置与所述通道的壁之间的摩擦接触，也可以清洁所述通道 的不期望的固体和其他颗粒物质。

公开(公告)号：US08556851B2

公开(公告)日：2013-10-15

申请号：US11477812

申请日：2006-06-30

申请人： Eran Hirszowicz ,  Shay Dubi

发明人： Eran Hirszowicz ,  Shay Dubi

IPC分类号： A61M29/00 ,  A61M31/00

CPC分类号： A61M25/1006 ,  A61M25/0119 ,  A61M25/104 ,  A61M2025/0183 ,  A61M2025/1015 ,  A61M2025/1068 ,  A61M2025/109

摘要： A catheter system suitable for the retrieval of debris and other solid or liquid matter from body passages, and the removal of said matter from the body. More particularly, a catheter system including two or more concentrically-arranged conduits and an inflatable element connected therebetween, wherein the inflatable element is arranged such that it may entrap solid or liquid matter in an internal annular cavity.

摘要翻译： 一种导管系统，适用于从身体通道中取出碎屑和其他固体或液体物质，并从体内去除所述物质。 更具体地，包括两个或多个同心布置的管道和连接在其间的可充气元件的导管系统，其中可膨胀元件被布置成使得其可以将固体或液体物质捕获在内部环形空腔中。

公开(公告)号：US20110313436A1

公开(公告)日：2011-12-22

申请号：US13211455

申请日：2011-08-17

申请人： Shay DUBI ,  Yair FELD

发明人： Shay DUBI ,  Yair FELD

IPC分类号： A61B17/08

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B17/0401 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/0441 ,  A61B2017/0496

摘要： The present invention provides an in vivo device for improving diastolic function of the heart, comprising: at least one elastic component that may be operatively connected to the external surface of the left or right ventricle of the heart by means of connecting elements, wherein said elastic component comprises essentially longitudinal members arranged such that the lateral separation therebetween may be increased or decreased in response to elastic deformation of said elastic component, and wherein said essentially longitudinal members are arranged such that said elastic component is curved in both the vertical and horizontal planes, such that its inner surface may be adapted to the curvature of the external ventricular surface of the heart, such that said elastic component is capable of exerting both radially outward expansive and tangentially-directed forces on the external surface of the cardiac ventricle.

摘要翻译： 本发明提供一种用于改善心脏舒张功能的体内装置，包括：至少一个弹性部件，其可通过连接元件与心脏的左心室或右心室的外表面可操作地连接，其中所述弹性 组件包括基本纵向构件，其布置成使得它们之间的横向分离可以响应于所述弹性构件的弹性变形而增加或减小，并且其中所述基本上纵向构件布置成使得所述弹性构件在垂直和水平面中均弯曲， 使得其内表面可以适应于心脏的外部心室表面的曲率，使得所述弹性部件能够在心室的外表面上施加径向向外的膨胀和切向力。

公开(公告)号：US07993258B2

公开(公告)日：2011-08-09

申请号：US11430878

申请日：2006-05-10

申请人： Yair Feld ,  Shay Dubi

发明人： Yair Feld ,  Shay Dubi

IPC分类号： A61N1/362

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B17/00491 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/064 ,  A61B2017/048 ,  A61F2/2487 ,  A61F2002/249 ,  A61F2002/30079 ,  A61F2210/009

摘要： A method and device featuring at least one component providing a potential to kinetic converted elastic, magnetic repulsion, or, an elastic and magnetic repulsion, pushing, pulling, or, pulling and pushing, type of radially outward expansive force or pressure to an inner, outer, intermediate, and, combination thereof, wall region of the left ventricle, for reducing intraluminal hydrostatic pressure of the left ventricle (LV filling pressure) during the ventricular diastolic stage of the cardiac cycle, thereby, improving diastolic function of the left ventricle of the heart in subjects having a condition of diastolic heart failure (DHF), while minimally disturbing systolic function of the heart. The expansive force or pressure is in a range of about 5-40 mm Hg, whereby, left ventricular end diastolic pressure (LVEDP) is reduced down to the normal range of about 6-12 mm Hg, during ventricular diastole of the heart.

摘要翻译： 一种方法和装置，其特征在于至少一个部件提供动力转换的弹性，磁性排斥，或弹性和磁性排斥，推动，拉动或拉动和推动径向向外的膨胀力或压力的类型到内部， 外部，中间和组合的左心室的壁区域，用于在心脏周期的心室舒张期期间降低左心室的腔内静水压（LV填充压力），由此改善左心室舒张功能 具有舒张性心力衰竭病症（DHF）的受试者的心脏，同时心脏的收缩功能最小化。 膨胀力或压力在约5-40mm Hg的范围内，由此，在心脏心室舒张期间，左心室舒张末期压（LVEDP）降低至约6-12mm Hg的正常范围。