公开(公告)号：US20090269794A1

公开(公告)日：2009-10-29

申请号：US12063347

申请日：2006-08-09

申请人： Akira Nakagawara ,  Keizo Takenaga ,  Shigenobu Mochizuki

发明人： Akira Nakagawara ,  Keizo Takenaga ,  Shigenobu Mochizuki

IPC分类号： C12Q1/02

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： A screening method comprising the following steps is provided. A step of culturing cells in the presence and in the absence of a test compound, a step of measuring HIF-1α expression in the respective cultured cells, and a step of determining the test compound to be a compound that inhibits onset or progression of familial amyotrophic lateral sclerosis if the HIF-1α expression in the cells cultured in the presence of the test compound is less than the HIF-1α expression in the cells cultured in the absence of the test compound.

摘要翻译： 提供了包括以下步骤的筛选方法。 在存在和不存在测试化合物的情况下培养细胞的步骤，测量各培养细胞中HIF-1α表达的步骤和测定化合物成为抑制家族性发作或进展的化合物的步骤 在受试化合物存在下培养的细胞中HIF-1α表达低于在不存在测试化合物时培养的细胞中的HIF-1α表达，肌萎缩性侧索硬化。

公开(公告)号：US06777954B2

公开(公告)日：2004-08-17

申请号：US10179987

申请日：2002-06-26

申请人： Hiroyasu Yamada ,  Shigenobu Mochizuki ,  Kazuyuki Katayama ,  Kazuhiro Kazama

发明人： Hiroyasu Yamada ,  Shigenobu Mochizuki ,  Kazuyuki Katayama ,  Kazuhiro Kazama

IPC分类号： G01R3100

CPC分类号： G01R31/025

摘要： An air conditioner includes an air conditioning unit, and three wiring lines for supplying power to the air conditioning unit. The three wiring lines are a pair of single phase AC power lines and an earth line which are to be connected to three source lines. The three source lines are a pair of single phase AC source lines and a ground line. The air conditioner also includes a detection unit including a detecting device that detects voltages between each of the AC power lines and the earth line, a conversion device that converts the voltages detected by the detecting device into logic level signals, a comparator that determines presence or absence of faulty connection between the three wiring lines and the three source lines by comparing the logic level signals obtained by the conversion device with reference logic level signals, and an output device that shows a result of determination made by the comparator.

摘要翻译： 空调机包括空调单元和用于向空调单元供电的三条布线。 三条线路是要连接到三根源极线的一对单相交流电源线和地线。 三条源极线是一对单相交流电源线和地线。 所述空调还包括检测单元，所述检测单元包括检测每个所述AC电力线和所述接地线之间的电压的检测装置，将由所述检测装置检测出的电压转换为逻辑电平信号的转换装置， 通过将由转换装置获得的逻辑电平信号与参考逻辑电平信号进行比较，在三条布线和三条源极线之间不存在故障连接，以及显示比较器确定结果的输出装置。