公开(公告)号：US20130289672A1

公开(公告)日：2013-10-31

申请号：US13976801

申请日：2011-12-22

申请人： Shiho Hakomori ,  Tsunenori Arai ,  Arisa Ito ,  Mei Takahashi

发明人： Shiho Hakomori ,  Tsunenori Arai ,  Arisa Ito ,  Mei Takahashi

IPC分类号： A61N5/06

CPC分类号： A61N5/0613 ,  A61B5/06 ,  A61B18/24 ,  A61B2018/00351 ,  A61B2018/00648 ,  A61B2090/065 ,  A61N5/0601 ,  A61N5/062

摘要： To provide a laser therapy apparatus that is capable of determining a contact state between a tip portion of a laser catheter and a tissue, which includes a buried state of the tip portion in the tissue, a laser therapy system, and a determination method.

摘要翻译： 提供一种能够确定激光导管的前端部分和组织之间的接触状态的激光治疗装置，其包括组织中的尖端部分的埋藏状态，激光治疗系统和确定方法。

公开(公告)号：US09277865B2

公开(公告)日：2016-03-08

申请号：US13583531

申请日：2011-03-07

申请人： Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

发明人： Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61N5/06 ,  A61B18/24 ,  A61B18/00 ,  A61B5/0402

CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61B5/4848 ,  A61B5/6852 ,  A61B5/6869 ,  A61B18/24 ,  A61B2018/00351 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0626

摘要： A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached to and detached from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser catheter and the photo-sensitive pharmaceutical absorbed in the tissue.

摘要翻译： 作为估计装置的光动力治疗装置是一种用于照射具有吸收光敏药物的组织的装置，所述光敏药物吸收激发光并发射荧光的激发光与从激光导管的尖端部分发射的激发光，包括 连接器，光源和光检测单元。 激光导管能够连接到连接器上并从连接器上拆下。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度或光谱，荧光从激光导管经由连接器进入，以估计组织是否由于从激光导管的尖端部分发射的激发光与第 光敏药物吸收在组织中。

公开(公告)号：US20130172697A1

公开(公告)日：2013-07-04

申请号：US13583547

申请日：2011-03-07

申请人： Koshi Tamamura ,  Shiho Hakomori ,  Takashi Yamaguchi ,  Tsunenori Arai ,  Arisa Ito

发明人： Koshi Tamamura ,  Shiho Hakomori ,  Takashi Yamaguchi ,  Tsunenori Arai ,  Arisa Ito

IPC分类号： A61B5/1459

CPC分类号： A61B5/1459 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602

摘要： [Object] To provide a calculation apparatus and a calculation method capable of calculating pharmaceutical concentration in a tissue in real time.[Solving Means] A photodynamic therapy apparatus as a calculation apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to calculate concentration of the photo-sensitive pharmaceutical in a tissue, the tip portion of the laser catheter contacting the tissue.

摘要翻译： 提供能够实时计算组织中的药物浓度的计算装置和计算方法。 解决方案作为计算装置的光动力治疗装置是一种用于照射具有吸收光敏药物的组织的装置，所述光敏药物吸收激发光并发射荧光的光敏药物与从 激光导管，包括连接器，光源和光检测单元。 激光导管能够连接到/从连接器分离。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度，荧光从激光导管经由连接器进入，以计算组织中感光药物的浓度，激光导管的尖端部分接触组织。

公开(公告)号：US20130123642A1

公开(公告)日：2013-05-16

申请号：US13583531

申请日：2011-03-07

申请人： Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

发明人： Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61B5/4848 ,  A61B5/6852 ,  A61B5/6869 ,  A61B18/24 ,  A61B2018/00351 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0626

摘要： A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser the catheter, including a connector, a light source, and a light detection unit. The laser the catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser the catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser the catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser the catheter and the photo-sensitive pharmaceutical absorbed in the tissue.

摘要翻译： 作为估计装置的光动力治疗装置是一种用于从吸收了光敏药物的组织照射吸光激发光并发射荧光的光敏药物与从激光器的尖端部分发射的激发光的导管的装置， 包括连接器，光源和光检测单元。 激光器能够将导管与连接器连接/分离。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度或光谱，荧光通过连接器从激光导入导管，以估计组织是否因激光的尖端部分发射的激发光之间的反应而发生变化 和吸收在组织中的感光药物。

公开(公告)号：US20130172863A1

公开(公告)日：2013-07-04

申请号：US13583140

申请日：2011-03-07

申请人： Shiho Hakomori ,  Takashi Yamaguchi ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito

发明人： Shiho Hakomori ,  Takashi Yamaguchi ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito

IPC分类号： A61B18/24

CPC分类号： A61B18/24 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61B5/1459 ,  A61B5/6885 ,  A61B5/7285 ,  A61N5/062

摘要： A photodynamic therapy apparatus as a determining apparatus is the photodynamic therapy apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, or a tissue absorbing the excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to determine whether the tip portion of the laser catheter contacts the tissue or not.

摘要翻译： 作为决定装置的光动力治疗装置是用于对具有吸收光敏药物的组织，吸收激发光并发出荧光的感光药物或吸收激发光并发出荧光的组织进行照射的光动力治疗装置， 从包括连接器，光源和光检测单元的激光导管的尖端部分发射的激发光。 激光导管能够连接到/从连接器分离。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度或光谱，荧光从激光导管经由连接器进入，以确定激光导管的尖端部分是否与组织接触。