公开(公告)号：US09388109B2

公开(公告)日：2016-07-12

申请号：US14129003

申请日：2012-06-21

Applicant: Hideo Kawachi ,  Shiro Kitamura ,  Yasuyoshi Ueda

Inventor： Hideo Kawachi ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: A61K31/12 ,  C07C49/577 ,  A23L2/52 ,  A23K1/16 ,  A23L1/30 ,  A61K8/34 ,  A61Q19/00 ,  C07C45/81 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23

CPC classification number: C07C49/577 ,  A23K20/111 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/347 ,  A61K9/28 ,  A61K31/122 ,  A61Q19/00 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23 ,  C07C45/81

Abstract: With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.

Abstract translation: 关于还原型辅酶Q10，没有关于晶体多晶型的存在的报道，已经认为常规获得的晶体形式仅是一种形式。 本发明涉及在通过差示扫描量热法（DSC）以5℃/ min的速率升温的温度升高期间具有指示在54±2℃熔化的吸热峰的还原型辅酶Q10晶体和/或还原型辅酶Q10晶体 通过粉末X射线（Cu-Kα）衍射，辅助Q10晶体在衍射角（2θ;±0.2°）为11.5°，18.2°，19.3°，22.3°，23.0°和33.3°处显示出特征峰。 晶体形式是在溶剂中具有较高熔点和较低溶解度的新型还原型辅酶Q10晶体，其稳定性优于常规已知的还原型辅酶Q10晶体。

公开(公告)号：US09315839B2

公开(公告)日：2016-04-19

申请号：US13020500

申请日：2011-02-03

Applicant: Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

Inventor： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C12P7/66 ,  C12P7/22

CPC classification number: C12P7/66 ,  C12P7/22

Abstract: The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.

Abstract translation: 本发明涉及一种还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有还原型辅酶Q10比例不小于70摩尔％的微生物细胞，任选地破坏细胞并回收所生成的还原型辅酶Q10。 本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至 此后氧化由此得到的还原型辅酶Q10。 根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

公开(公告)号：US08568779B2

公开(公告)日：2013-10-29

申请号：US12522792

申请日：2008-01-10

Applicant: Kento Kanaya ,  Shiro Kitamura ,  Takahiro Ueda

Inventor： Kento Kanaya ,  Shiro Kitamura ,  Takahiro Ueda

IPC: A61K9/16 ,  A61K31/122 ,  C07C46/10 ,  A61K9/107 ,  C07C50/28 ,  C09K15/08

CPC classification number: A61K31/122 ,  A23V2250/314 ,  A61K9/1075 ,  A61K9/141 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/1688 ,  C07C46/10 ,  C07C50/28 ,  C09K15/08

Abstract: The present invention aims to provide a production method capable of industrially and producing coenzyme Q10 particles having a high content and superior powder flowability characteristics by simple facility and convenient operations. The present invention provides a method of producing coenzyme Q10 particles, including mixing coenzyme Q10 and a poor solvent by stirring at a temperature not less than the melting point of coenzyme Q10, dispersing coenzyme Q10 into the form of oil droplets, and cooling them to a solidification temperature of coenzyme Q10 or below while stirring the dispersion to give solid particles, wherein the poor solvent is an aqueous solution comprising an organic solvent and/or a surfactant having an HLB of 6 or above. According to the production method of the present invention, coenzyme Q10 particles markedly superior in powder characteristics, and having, for example, a powder flowability index of not less than 80 can be obtained.

Abstract translation: 本发明的目的是提供一种能够通过简单的设备和方便的操作在工业上生产具有高含量和优异的粉末流动性特性的辅酶Q10颗粒的生产方法。 本发明提供一种生产辅酶Q10颗粒的方法，包括在不少于辅酶Q10的熔点的温度下搅拌辅助辅酶Q10和不良溶剂，将辅酶Q10分散成油滴形式，并将其冷却至 在搅拌分散体以得到固体颗粒的同时，辅酶Q10或更低的固化温度，其中不良溶剂是包含HLB为6或更高的有机溶剂和/或表面活性剂的水溶液。 根据本发明的制造方法，可以得到粉末特性显着优异的，具有例如不小于80的粉末流动指数的辅酶Q10颗粒。

公开(公告)号：US08067217B2

公开(公告)日：2011-11-29

申请号：US11315161

申请日：2005-12-23

Applicant: Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

Inventor： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C12N9/98

CPC classification number: A61K9/4816

Abstract: The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.

Abstract translation: 本发明的目的是提供一种用于稳定保存含有还原型辅酶Q10的胶囊的方法，所述还原型辅酶Q10可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药​​物， 补救剂，预防药物等。本发明涉及一种保存还原型辅酶Q10的方法，其包括制备或获得含有还原型辅酶Q10的胶囊，并且将胶囊周围的环境控制在相对湿度不小于0％但不超过 超过60％。 根据该方法，可以稳定地保持还原型辅酶Q10，而不需要巨大的成本和劳动力，或特殊设备。

公开(公告)号：US20110263906A1

公开(公告)日：2011-10-27

申请号：US13176479

申请日：2011-07-05

Applicant: Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

Inventor： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C07C41/40

CPC classification number: C07C41/40 ,  C07C43/23

Abstract: The present invention provides a method of producing reduced coenzyme Q10 crystals suitable for commercial scale production thereof.According to a method of the present invention of producing a reduced coenzyme Q10 crystal which comprises a crystallization of reduced coenzyme Q10 in a solution of alcohols and/or ketones, reduced coenzyme Q10 crystal excellent in slurry properties and crystalline properties maybe obtained. Moreover, an isolation process including a crystal separation or the whole process including the isolation process maybe minimized and simplified. Thus, highly pure reduced coenzyme Q10 may be obtained in a high yield.

Abstract translation: 本发明提供了适合于商业规模生产的还原型辅酶Q10晶体的制造方法。 根据本发明的制备还原型辅酶Q10晶体的方法，所述还原型辅酶Q10晶体包括在醇和/或酮溶液中结晶还原型辅酶Q10，可得到浆料性能和结晶性能优异的还原型辅酶Q10晶体。 此外，包括晶体分离的分离过程或包括隔离过程的整个过程可以被最小化和简化。 因此，可以高产率获得高纯度还原型辅酶Q10。

公开(公告)号：US07897169B2

公开(公告)日：2011-03-01

申请号：US10501669

申请日：2003-01-20

Applicant: Yasuyoshi Ueda ,  Shiro Kitamura ,  Tadayoshi Shiraishi ,  Masayuki Abe ,  Takeshi Kawashima ,  Toshinori Ikehara

Inventor： Yasuyoshi Ueda ,  Shiro Kitamura ,  Tadayoshi Shiraishi ,  Masayuki Abe ,  Takeshi Kawashima ,  Toshinori Ikehara

IPC: A61K47/00

CPC classification number: A23G9/32 ,  A21D2/14 ,  A23C11/04 ,  A23C19/082 ,  A23D7/0056 ,  A23D7/015 ,  A23D9/007 ,  A23F3/163 ,  A23F5/243 ,  A23L7/111 ,  A23L7/122 ,  A23L7/13 ,  A23L7/165 ,  A23L9/12 ,  A23L9/22 ,  A23L19/03 ,  A23L19/14 ,  A23L23/00 ,  A23L27/60 ,  A23L33/10 ,  A23P20/11 ,  A23P30/40 ,  A23V2002/00 ,  C11B5/0092 ,  A23V2250/314

Abstract: To provide a food which suitably supply ubiquinol, a substance indispensable to the living body but is liable to be decreased and fall short of the requirements, through ingestion in the same ways as the ordinary foods in daily living. A ubiquinol-enriched oil/fat-containing food.

Abstract translation: 提供适当地提供泛醌的食物，其通过以与日常生活中的普通食物相同的方式摄取，这是生物体不可缺少但易于降低并且不符合要求的物质。 富含ubiquinol的含油/脂肪的食物。

公开(公告)号：US20100234643A1

公开(公告)日：2010-09-16

申请号：US12740086

申请日：2008-10-29

Applicant: Takahiro Ueda ,  Shiro Kitamura

Inventor： Takahiro Ueda ,  Shiro Kitamura

IPC: C07C45/41

CPC classification number: C07C41/26 ,  C07C41/40 ,  C07C43/23

Abstract: The present invention aims to provide reduced coenzyme Q10, which is useful as food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, and a production method of reduced coenzyme Q10. The present invention provides a production method of reduced coenzyme Q10, which includes reducing oxidized coenzyme Q10 with ascorbic acid or its analogue(s) as a reducing agent in a water-containing organic solvent at not more than pH 5. Using the method, the reaction time can be drastically shortened even without adding a basic substance and the like, and unpreferable side reactions can be minimized. Therefore, reduced coenzyme Q10 with high quality can be produced.

Abstract translation: 本发明旨在提供可用作食物，具有营养功能要求的食物，用于特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，化妆品，药​​物，治疗药物，预防性药物的还原型辅酶Q10 药物等，以及还原型辅酶Q10的制造方法。 本发明提供还原型辅酶Q10的制造方法，该方法包括在不高于pH 5的含水有机溶剂中，用抗坏血酸或其类似物还原氧化型辅酶Q10作为还原剂。使用该方法， 即使没有添加碱性物质等，反应时间也可以大大缩短，并且不利的副反应可以最小化。 因此，可以生产具有高质量的还原型辅酶Q10。

公开(公告)号：US20100168249A1

公开(公告)日：2010-07-01

申请号：US12710888

申请日：2010-02-23

Applicant: Shiro KITAMURA ,  Takahiro UEDA

Inventor： Shiro KITAMURA ,  Takahiro UEDA

IPC: A61K31/122 ,  A61K8/35 ,  A23D9/007

CPC classification number: A61K31/122 ,  A21D2/14 ,  A21D2/165 ,  A23D7/0053 ,  A23D7/0056 ,  A23D9/007 ,  A23D9/013 ,  A23K20/111 ,  A23K20/158 ,  A23L33/10 ,  A23L33/115 ,  A23L33/12 ,  A61K8/355 ,  A61Q19/00

Abstract: The invention provides a composition containing reduced coenzyme Q10, which is useful as a pharmaceutical product, food, cosmetic, animal drug, feed, and the like, as well as a stabilization method thereof. The oxidation of reduced coenzyme Q10 into oxidized coenzyme Q10 by molecular oxygen can be suppressed by setting, in a composition containing reduced coenzyme Q10 and at least one kind of oil component selected from the group consisting of fat, oil, a mixture thereof, fatty acid, wax and a surfactant, the weight ratio of the reduced coenzyme Q10 to the oil component to not less than 1/4 when the composition is a liquid, and not less than 1/9 when the composition is a solid.

Abstract translation: 本发明提供含有还原型辅酶Q10的组合物，其可用作药物产品，食品，化妆品，动物药物，饲料等，以及其稳定化方法。 还原型辅酶Q10通过分子氧氧化成氧化型辅酶Q10可以通过在含有还原型辅酶Q10的组合物和选自脂肪，油，其混合物，脂肪酸中的至少一种油成分 ，蜡和表面活性剂时，当组合物为液体时，还原型辅酶Q10与油性成分的重量比为1/4以上，当组合物为固体时为1/9以上。

公开(公告)号：US07524975B2

公开(公告)日：2009-04-28

申请号：US10490641

申请日：2002-10-11

Applicant: Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

Inventor： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

IPC: C07D311/00

CPC classification number: C07D311/06 ,  A23K20/111 ,  A23K20/121 ,  A23K50/00 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A61K31/12 ,  A61K31/353 ,  A61K31/37 ,  A61K36/484 ,  A61K2300/00

Abstract: The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

Abstract translation: 本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。 本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯基类黄酮，不含异戊烯基黄酮的查耳酮衍生物，不含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或其酯化物质， 食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。

公开(公告)号：US20080152636A1

公开(公告)日：2008-06-26

申请号：US11896976

申请日：2007-09-07

Applicant: Takahiro Ueda ,  Shiro Kitamura ,  Yoshiyuki Shinagawa ,  Taizou Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

Inventor： Takahiro Ueda ,  Shiro Kitamura ,  Yoshiyuki Shinagawa ,  Taizou Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

IPC: A61K8/35

CPC classification number: A23K20/10 ,  A23K20/158 ,  A23L33/10 ,  A61K8/347 ,  A61K8/553 ,  A61K9/08 ,  A61K31/122 ,  A61Q19/00

Abstract: The present invention provides a method of improving the absorbability of reduced coenzyme Q10, which includes affording a composition containing lysolecithin and reduced coenzyme Q10 in combination. The composition containing lysolecithin and reduced coenzyme Q10 of the present invention shows superior absorption of reduced coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.

Abstract translation: 本发明提供了提高还原型辅酶Q 10的吸收性的方法，其包括组合物提供含有溶血卵磷脂和还原型辅酶Q 10的组合物。 含有本发明的溶血卵磷脂和还原型辅酶Q 10的组合物显示出优异的还原型辅酶Q 10的吸收，并且可以用于食品，具有营养功能的食物，具体的食品 保健用品，营养补充剂，营养制品，动物药，饮料，饲料，宠物食品，化妆品，药​​品，治疗药物，预防药物等。