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    Antiviral drugs containing heteropolyanions
    1.
    发明授权
    Antiviral drugs containing heteropolyanions 失效
    含有杂多阴离子的抗病毒药物

    公开(公告)号：US06565890B2

    公开(公告)日：2003-05-20

    申请号：US09934751

    申请日：2001-08-22

    申请人： Shiro Shigeta ,  Toshihiro Yamase

    发明人： Shiro Shigeta ,  Toshihiro Yamase

    IPC分类号： A01N5900

    CPC分类号： A61K33/00 ,  Y10S514/888

    摘要： A compound for use especially as an antiviral drug, mainly containing salts of heteropolyanions consisting of a tungstoantimonate (III) vanadium-mixed metal oxide or related salts represented by formula [(XW9O33)2V3O3]P−, where p is a positive number between 9 and 12 and X is Sb, P. As or Bi and especially Sb. An antiviral drug having a broad spectrum of antiviral activity, high potent efficacy and low toxicity is provided.

    摘要翻译： 一种特别用作抗病毒药物的化合物，主要含有由呫吨锑酸盐（III）钒混合金属氧化物或由式[（XW9O33）2V3O3] P-表示的相关盐组成的杂多阴离子盐，其中p为9之间的正数 12和X是Sb，P.As或Bi，特别是Sb。 提供具有广谱抗病毒活性，高效力和低毒性的抗病毒药物。

    4′-C-ethynyl pyrimidine nucleosides and pharmaceutical compositions thereof
    5.
    发明授权
    4′-C-ethynyl pyrimidine nucleosides and pharmaceutical compositions thereof 有权
    4'-C-乙炔基嘧啶核苷及其药物组合物

    公开(公告)号：US06403568B1

    公开(公告)日：2002-06-11

    申请号：US09941845

    申请日：2001-08-30

    申请人： Hiroshi Ohrui ,  Shiro Shigeta ,  Eiichi Kodama ,  Haruhiko Machida ,  Satoru Kohgo ,  Hiroaki Mitsuya

    发明人： Hiroshi Ohrui ,  Shiro Shigeta ,  Eiichi Kodama ,  Haruhiko Machida ,  Satoru Kohgo ,  Hiroaki Mitsuya

    IPC分类号： A61K3170

    CPC分类号： C07H19/06 ,  C07H19/16

    摘要： The invention provides 4′-C-ethynyl pyrimidine nucleosides (other than 4′-C-ethynylthymidine) represented by formula [I]: wherein B represents a base selected from the group consisting of pyrimidine and derivatives thereof; X represents a hydrogen atom or a hydroxyl group; and R represents a hydrogen atom or a phosphate residue; and a pharmaceutical composition containing any one of the compounds and a pharmaceutically acceptable carrier. Preferably, the composition is used as an anti-HIV agent or a drug for treating AIDS.

    摘要翻译： 本发明提供由式[I]表示的4'-C-乙炔基嘧啶核苷（不包括4'-C-乙炔基胸苷）：其中B代表选自嘧啶及其衍生物的碱; X表示氢原子或羟基; R表示氢原子或磷酸酯残基; 以及含有上述化合物和药学上可接受的载体的药物组合物。 优选地，组合物用作抗HIV剂或用于治疗AIDS的药物。

    4′-C-ethynyl pyrimidine nucleoside compounds and pharmaceutical compositions
    6.
    发明授权
    4′-C-ethynyl pyrimidine nucleoside compounds and pharmaceutical compositions 有权
    4'-C-乙炔基嘧啶核苷化合物和药物组合物

    公开(公告)号：US06291670B1

    公开(公告)日：2001-09-18

    申请号：US09570041

    申请日：2000-05-12

    申请人： Hiroshi Ohrui ,  Shiro Shigeta ,  Eiichi Kodama ,  Haruhiko Machida ,  Satoru Kohgo ,  Hiroaki Mitsuya

    发明人： Hiroshi Ohrui ,  Shiro Shigeta ,  Eiichi Kodama ,  Haruhiko Machida ,  Satoru Kohgo ,  Hiroaki Mitsuya

    IPC分类号： C07H1919

    CPC分类号： C07H19/06 ,  C07H19/16

    摘要： The invention provides 4′-C-ethynyl pyrimidine nucleosides (other than 4′-C-ethynylthymidine) represented by formula [I]: wherein B represents a base selected from the group consisting of pyrimidine and derivatives thereof; X represents a hydrogen atom or a hydroxyl group; and R represents a hydrogen atom or a phosphate residue; and a pharmaceutical composition containing any one of the compounds and a pharmaceutically acceptable carrier. Preferably, the composition is used as an anti-HIV agent or a drug for treating AIDS.

    摘要翻译： 本发明提供由式[I]表示的4'-C-乙炔基嘧啶核苷（不包括4'-C-乙炔基胸苷）：其中B代表选自嘧啶及其衍生物的碱; X表示氢原子或羟基; R表示氢原子或磷酸酯残基; 以及含有上述化合物和药学上可接受的载体的药物组合物。 优选地，组合物用作抗HIV剂或用于治疗AIDS的药物。

    Transformed cell lines producing human monoclonal antibodies specific for Pseudomonas aeruginosa serotypes
    8.
    发明授权
    Transformed cell lines producing human monoclonal antibodies specific for Pseudomonas aeruginosa serotypes 失效
    产生对铜绿假单胞菌血清型特异性的人单克隆抗体的转化细胞系

    公开(公告)号：US5521085A

    公开(公告)日：1996-05-28

    申请号：US41244

    申请日：1993-04-01

    申请人： Tamotsu Fukuda ,  Yasushi Ono ,  Shiro Shigeta ,  Yasuyuki Kuriowa ,  Hisayoshi Ooka

    发明人： Tamotsu Fukuda ,  Yasushi Ono ,  Shiro Shigeta ,  Yasuyuki Kuriowa ,  Hisayoshi Ooka

    IPC分类号： A61K38/00 ,  C07K16/12 ,  C12N5/16 ,  C12N5/10 ,  C07K16/18

    CPC分类号： C07K16/1214 ,  C12N5/163 ,  A61K38/00

    摘要： The present invention relates to human monoclonal antibodies capable of plurally binding with O-antigens of Pseudomonas aeruginosa, relates to novel parent cell lines for producing human hybridomas derived from human immunoglobulin synthesizing cells, which cell lines themselves incapable of producing human immunoglobulin and capable of fusing with human antibody-producing cells, relates to human-human hybridomas which can secrete monoclonal antibodies capable of binding with at least one of serotypes of Pseudomonas aeruginosa, relates to pharmaceutical compositions for prophylaxis or therapy of Pseudomonas aeruginosa infectious diseases, and relates to prophylactic or therapeutic methods for Pseudomonas aeruginosa infectious diseases.

    摘要翻译： 本发明涉及能够多次与铜绿假单胞菌的O-抗原结合的人单克隆抗体，涉及用于产生源自人免疫球蛋白合成细胞的人杂交瘤的新型亲本细胞系，该细胞系本身不能产生人免疫球蛋白并能够融合 涉及可以分泌能够与铜绿假单胞菌的至少一种血清型结合的单克隆抗体的人 - 人杂交瘤，涉及用于预防或治疗铜绿假单胞菌感染性疾病的药物组合物，涉及预防或 铜绿假单胞菌感染性疾病的治疗方法。

    Antitumor agent and dnase
    9.
    发明申请
    Antitumor agent and dnase 审中-公开
    抗肿瘤药物和dnase

    公开(公告)号：US20060228347A1

    公开(公告)日：2006-10-12

    申请号：US11337544

    申请日：2006-01-24

    申请人： Susumu Sunaga ,  Shiro Shigeta ,  Kenji Konno

    发明人： Susumu Sunaga ,  Shiro Shigeta ,  Kenji Konno

    IPC分类号： A61K38/46 ,  C12N9/22 ,  A61K9/127

    CPC分类号： C12N9/22 ,  A61K9/1271 ,  A61K9/48 ,  A61K38/00

    摘要： An antitumor agent comprising as an active ingredient a DNase, and novel DNases are disclosed. The novel DNases are derived from human stomach cancer cell line MKN-28 or human cervical cancer cell line HeLa, and do not act on normal cells but specifically act on cancer cells.

    摘要翻译： 公开了包含DNase的活性成分和新型DNase的抗肿瘤剂。 新型DN酶源自人胃癌细胞系MKN-28或人宫颈癌细胞系HeLa，不作用于正常细胞，而是特异性地作用于癌细胞。