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    1-Phenyl-4-carbamoyl piperazine compounds, process for preparation thereof and utilizations thereof
    2.
    发明授权
    1-Phenyl-4-carbamoyl piperazine compounds, process for preparation thereof and utilizations thereof 失效
    1-苯基-4-氨基甲酰基哌嗪化合物，其制备方法及其用途

    公开(公告)号：US4446133A

    公开(公告)日：1984-05-01

    申请号：US235112

    申请日：1981-02-13

    申请人： Yutaka Okazaki ,  Hiroshi Tokuda ,  Shiyoichiro Miyahara ,  Yoshitsugu Yamada

    发明人： Yutaka Okazaki ,  Hiroshi Tokuda ,  Shiyoichiro Miyahara ,  Yoshitsugu Yamada

    IPC分类号： C07D295/20 ,  A61K31/495 ,  A61P37/04 ,  C07D295/215 ,  C07D241/04

    CPC分类号： C07D295/215 ,  Y10S514/825

    摘要： The present invention relates to a novel piperazine compound represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen or halogen atom, an alkoxy, carboxy or alkoxycarbonyl group or a group R.sup.3 CO-- in which R.sup.3 stands for an alkyl group having 1 to 4 carbon atoms, R.sup.1 stands for a hydrogen atom or an alkyl group, and R.sup.2 stands for a hydrogen atom or an alkyl group.These compounds are valuable as immunopotentiators, such as for the treatment of chronic rheumatoid arthritis and other diseases accompanied by reduction or abnormal change of the immune function.

    摘要翻译： 本发明涉及由以下通式（I）表示的新型哌嗪化合物：其中X表示氢或卤素原子，烷氧基，羧基或烷氧基羰基或基团R 3 CO-，其中R 3 代表具有1至4个碳原子的烷基，R1代表氢原子或烷基，R2代表氢原子或烷基。 这些化合物作为免疫增强剂是有价值的，例如用于治疗慢性类风湿性关节炎和伴有免疫功能的减少或异常变化的其它疾病。