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    IMIDAZOPYRIDAZINE COMPOUNDS
    1.
    发明申请
    IMIDAZOPYRIDAZINE COMPOUNDS 审中-公开
    咪唑吡嗪化合物

    公开(公告)号：US20120323002A1

    公开(公告)日：2012-12-20

    申请号：US13532258

    申请日：2012-06-25

    申请人： Takashi YAMAMOTO ,  Ayatoshi ANDO ,  Nobuhiko HAYAKAWA ,  Masatsugu NOGUCHI ,  Hikaru NISHIO ,  Agung EVIRYANTI ,  Ryohei YOKOYAMA ,  Shunsuke KAGEYAMA ,  Kanna KURIBAYASHI

    发明人： Takashi YAMAMOTO ,  Ayatoshi ANDO ,  Nobuhiko HAYAKAWA ,  Masatsugu NOGUCHI ,  Hikaru NISHIO ,  Agung EVIRYANTI ,  Ryohei YOKOYAMA ,  Shunsuke KAGEYAMA ,  Kanna KURIBAYASHI

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/5377

    摘要： By searching various compounds having an inhibiting activity against IL-12/IL-23 production, the present invention provides a pharmaceutical composition or a therapeutic or preventive agent for diseases related to IL-12/IL-23 excessive production each of which comprises the compound(s) of the present invention.More specifically, the present invention provides an imidazopyridazine compound having an inhibiting activity against IL-12/IL-23 production or pharmaceutically acceptable salts thereof; and a useful pharmaceutical composition or a useful therapeutic or preventive agent for diseases related to IL-12/IL-23 excessive production each of which comprises said compound or pharmaceutically acceptable salts thereof.

    摘要翻译： 通过搜索对IL-12 / IL-23生产具有抑制活性的各种化合物，本发明提供了与IL-12 / IL-23过量产生有关的疾病的药物组合物或治疗或预防剂，其中每种含有化合物 （s）。 更具体地说，本发明提供了具有抑制IL-12 / IL-23生产活性的咪唑并哒嗪化合物或其药学上可接受的盐; 以及用于与IL-12 / IL-23过量产生有关的疾病的有用的药物组合物或有用的治疗或预防剂，其中每一种包含所述化合物或其药学上可接受的盐。

    Process for producing subunit peptide originating in polymer protein
    2.
    发明授权
    Process for producing subunit peptide originating in polymer protein 失效
    用于产生源自聚合物蛋白质的亚单位肽的方法

    公开(公告)号：US07270972B1

    公开(公告)日：2007-09-18

    申请号：US09926256

    申请日：2000-03-31

    申请人： Naoyuki Fukuchi ,  Shunsuke Kageyama ,  Morikazu Kito ,  Takashi Kayahara ,  Hiroshi Yamamoto

    发明人： Naoyuki Fukuchi ,  Shunsuke Kageyama ,  Morikazu Kito ,  Takashi Kayahara ,  Hiroshi Yamamoto

    IPC分类号： C12Q1/56 ,  A61K38/00

    CPC分类号： C07K14/46

    摘要： It is provided a method for producing a subunit peptide originating from an oligomeric protein having disulfide bonds within a subunit and between subunits. The method comprises producing a subunit originating from an oligomeric protein having disulfide bonds within a subunit and between subunits by the following steps: (a) a step of refolding the subunit by denaturing the oligomeric protein or its subunit in a solution with a protein-denaturing agent and removing the denaturing agent from the solution in the presence of polyoxyalkyl polyether having a functional group that reacts with a thiol group; and (b) a step of isolating the subunit bonded to the polyoxyalkyl polyether from the solution.

    摘要翻译： 提供了一种用于产生源自在亚基内和亚单位之间具有二硫键的寡聚蛋白质的亚单位肽的方法。 该方法包括通过以下步骤产生源自亚基内和亚基之间具有二硫键的寡聚蛋白的亚基：（a）通过使蛋白质变性的溶液中的寡聚蛋白质或其亚基变性来重新折叠亚基的步骤 在具有与硫醇基反应的官能团的聚氧烷基聚醚的存在下从溶液中除去变性剂; 和（b）从溶液中分离与聚氧烷基聚醚键合的亚基的步骤。