公开(公告)号：US20250060363A1

公开(公告)日：2025-02-20

申请号：US18934777

申请日：2024-11-01

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Spencer Lin ,  Christopher Reamer ,  Ryan Spears

IPC: G01N33/531 ,  G01N33/52 ,  G01N33/536 ,  G01N33/543

Abstract: Processes for quantifying an amount of functional groups immobilized on a solid support are described herein. The processes allow for determining whether sufficient functional groups are provided on a solid support for the attachment of a first binding pair member for the detection of a target analyte.

公开(公告)号：US12203831B2

公开(公告)日：2025-01-21

申请号：US17250853

申请日：2019-09-23

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Frank Vitzthum ,  Huey Lee ,  Michelle Son

IPC: A61K9/127 ,  G01N1/34 ,  G01N1/40

Abstract: Disclosed herein are compositions and methods for removing interfering substances from biological samples, biochemical assays, or reagents used in biological samples using porous liposomes that capture and in some instances enrich said interfering substances within the liposomes.

公开(公告)号：US20250011755A1

公开(公告)日：2025-01-09

申请号：US18887674

申请日：2024-09-17

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Alex Hofai Lee ,  Daniel Chu

IPC: C12N15/10 ,  B01F31/44 ,  B01F31/441 ,  B01F33/452 ,  B01F33/81 ,  B01F101/23 ,  B01L3/00 ,  B03C1/01 ,  B03C1/28

Abstract: An apparatus, vortex generator assembly and method for automated cell lysis and nucleic acid purification and processing. The vortex generator assembly includes sample holder having a lysis well, at least one wash well, and an elution well. The vortex generator assembly also includes a sample holder cover having a plurality of vibration rods for creating a vortex in the wells of the sample holder. The apparatus includes motor operating a rotating cam to cause the vibration rods to vibrate and create the vortex in a well holding fluid and magnetic beads, wherein the vortexing speed is sufficient to overcome the magnetic attraction between the beads and disperse the beads in solution, to collect nucleic acids such as DNA.

公开(公告)号：US12167255B2

公开(公告)日：2024-12-10

申请号：US16949817

申请日：2020-11-16

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Spencer Lin ,  Kwasi Osae-Kwapong ,  Omar Quraishi ,  Seema Sinha ,  Michele Smith ,  SunRay DiFrancesco ,  Ryan Spears ,  Dharini Rawal ,  Debra Hovanec-Burns ,  Robert Owens

IPC: H04W24/02 ,  A61K38/00 ,  A61K38/17 ,  C07K14/435 ,  C07K14/47 ,  G01N33/96 ,  H04B7/06 ,  H04L41/0806 ,  H04W8/00 ,  H04W72/044 ,  H04W84/18

Abstract: A human insulin-like growth factor (IGF) binding protein stock solution and method of making the same include a non-recombinant human IGF binding protein-3 (nr-IGFBP-3) in an aqueous buffered medium. The concentration of the nr-IGFBP-3 in the stock solution ranges from about 16 micrograms per milliliter (μg/ml) to about 40 μg/ml. A kit includes a set of calibrators for nr-IGFBP-3. The set of calibrators includes the nr-IGFBP-3 in different concentrations.

公开(公告)号：US20240335839A1

公开(公告)日：2024-10-10

申请号：US18696338

申请日：2022-09-28

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： George Sorensen

IPC: B01L9/06

CPC classification number: B01L9/06 ,  B01L2200/025 ,  B01L2300/0848 ,  B01L2300/123 ,  B01L2300/14

Abstract: Embodiments provide a tube retainer system, including: an outer body; a diaphragm having a circular opening; a valve including a valve head and a valve stem attached to the valve head; a cam; a camshaft extending through the cam; a drive gear attached to the camshaft; a restraint gear attached to the camshaft; a push bar located below the diaphragm; and a pawl. The diaphragm, the cam, the drive gear, the restraint gear, the push bar, and the pawl are all provided in the outer body, when a bottom of a tube is inserted into the circular opening and a downward pressure is applied on the diaphragm, the cam is oriented to close the valve to form a partial vacuum in the outer body to secure the bottom of the tube within the circular opening.

公开(公告)号：US20240329628A1

公开(公告)日：2024-10-03

申请号：US18579318

申请日：2022-07-12

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Narayanan Ramakrishnan

IPC: G05B23/02 ,  G01N35/10

CPC classification number: G05B23/024 ,  G01N35/1016 ,  G05B23/0281

Abstract: Methods of early real-time detection or prediction of aspiration faults in an automated diagnostic analysis system include an artificial intelligence algorithm configured to use either cluster analysis or probabilistic graphical modeling based on an aspiration pressure measurement signal waveform. Aspiration faults may include short-volume aspiration and unwanted gel pick-up. These methods may allow for timely termination of an aspiration process so as to avoid or minimize possible detrimental downstream consequences such as faulty sample test results and/or instrument downtime for servicing and cleanup. Apparatus for early real-time detection or prediction of aspiration faults are provided as are other aspects.

公开(公告)号：US20240310395A1

公开(公告)日：2024-09-19

申请号：US18546959

申请日：2022-02-17

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： Yao-Jen Chang ,  Rayal Raj Prasad Nalam Venkat ,  Benjamin S. Pollack ,  Vivek Singh ,  Venkatesh NarasimhaMurthy ,  Ankur Kapoor

IPC: G01N35/00 ,  G01N35/10

CPC classification number: G01N35/00712 ,  G01N35/1016 ,  G01N2035/1025

Abstract: Methods of operating a diagnostic laboratory system include providing a module configured to perform a function on an item in the diagnostic laboratory system; providing a plurality of sensors, each of the plurality of sensors configured to monitor the function or the item and generate sensor data in response to the monitoring; checking an operational status of a first sensor of the plurality of sensors; receiving sensor data from at least one of the plurality of sensors; and scaling sensor data from the first sensor in response to the operational status and the sensor data to generate revised sensor data. Systems including a middleware server configured to carry out the methods are provided as are other aspects.

公开(公告)号：US20240302370A1

公开(公告)日：2024-09-12

申请号：US18261427

申请日：2022-01-14

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Sai Patibandla ,  Krishna Singh ,  Geraldine Arrode-Bruses

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N2333/165 ,  G01N2469/10

Abstract: Methods of utilizing sample lysis reagent compositions in the handling of samples containing viruses, such as (but not limited to) severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), are disclosed. Kits containing the sample lysis reagent compositions are also disclosed.

公开(公告)号：US20240255533A1

公开(公告)日：2024-08-01

申请号：US18636098

申请日：2024-04-15

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Arnold Rudorfer ,  Steven Magowan ,  Govindraj Peesapati ,  Robert Kachelries

IPC: G01N35/00 ,  G16H40/40

CPC classification number: G01N35/00623 ,  G01N35/00871 ,  G16H40/40

Abstract: Methods of predicting failures of in vitro diagnostic instruments include monitoring, with one or more monitoring devices associated with one or more components of the in vitro diagnostic instrument, one or more condition-based maintenance (CBM) parameters of the in vitro diagnostic instrument, providing the one or more condition-based maintenance parameters to a local database, transmitting condition-based maintenance data to a remote service location, storing the condition-based maintenance data at the remote service location, analyzing the condition-based maintenance data according to a failure prediction engine including failure prediction criteria, and performing an action based on predefined deviation from the failure prediction criteria. Apparatus configured to carry out the methods are provided, as are other aspects.

公开(公告)号：US20240254088A1

公开(公告)日：2024-08-01

申请号：US18442393

申请日：2024-02-15

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Anand Natrajan ,  David Sharpe ,  Qingping Jiang ,  David Wen

IPC: C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/58

CPC classification number: C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/582

Abstract: Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.