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公开(公告)号：US20120251544A1
公开(公告)日：2012-10-04
申请号：US13494912
申请日：2012-06-12
Applicant: Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC: C07K16/40 , A61P7/00 , A61K39/395
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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公开(公告)号：US20120093818A1
公开(公告)日：2012-04-19
申请号：US13174423
申请日：2011-06-30
Applicant: Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC: A61K39/395 , C12P21/02 , A61P7/00 , C07K16/40
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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公开(公告)号：US20100109417A1
公开(公告)日：2010-05-06
申请号：US12648558
申请日：2009-12-29
Applicant: Eric Jackson , Hal Hirtz , James Dale , John Jordan , David Eddy , Simon Mark Jackson
Inventor： Eric Jackson , Hal Hirtz , James Dale , John Jordan , David Eddy , Simon Mark Jackson
Abstract: The present invention is directed to an excavator that is operable in manual and automatic modes and uses state machines to effect unit operations, rotationally offset swing actuators to rotate boom and cutter head, a fail safe hydraulic system to maintain gripper pressure in the event of a malfunction of the hydraulic system, differing position and pressure control functions in the hydraulic actuators, a kinematic module to effect pitch and roll adjustments, a cutting face profile generator to generate a profile of the excavation face, and an optimization module to realize a high degree of optimization of excavator operation.
Abstract translation: 本发明涉及一种可在手动和自动模式下操作的挖掘机，并且使用状态机来实现单元操作，旋转地偏移摆动致动器以使悬臂和切割头旋转，故障安全液压系统在以下情况下保持夹持器压力 液压系统的故障，液压致动器中的不同的位置和压力控制功能，用于实现俯仰和滚动调节的运动模块，用于产生挖掘面的轮廓的切割面轮廓生成器，以及实现高度的优化模块 挖掘机运行优化。
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4.发明授权Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) 有权抗原结合蛋白与蛋白转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）
公开(公告)号：US08168762B2
公开(公告)日：2012-05-01
申请号：US13251955
申请日：2011-10-03
Applicant: Simon Mark Jackson , Bei Shan , Wenyan Shen , Chadwick Terence King
Inventor： Simon Mark Jackson , Bei Shan , Wenyan Shen , Chadwick Terence King
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
Abstract translation: 描述了与Proprotein转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述了使用抗原结合蛋白质向PCSK9检测样品中PCSK9的量的方法。
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5.发明授权Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) 有权抗原结合蛋白与蛋白转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）
公开(公告)号：US08030457B2
公开(公告)日：2011-10-04
申请号：US12197093
申请日：2008-08-22
Applicant: Simon Mark Jackson , Bei Shan , Wenyan Shen , Chadwick Terence King
Inventor： Simon Mark Jackson , Bei Shan , Wenyan Shen , Chadwick Terence King
IPC: C07K16/26 , C07K16/00 , A61K39/395
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
Abstract translation: 描述了与Proprotein转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述了使用抗原结合蛋白质向PCSK9检测样品中PCSK9的量的方法。
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6.发明申请ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) 有权抗原蛋白质结合蛋白转移酶突变体KEXIN 9型（PCSK9）
公开(公告)号：US20090142352A1
公开(公告)日：2009-06-04
申请号：US12197093
申请日：2008-08-22
Applicant: Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC: A61K39/395 , C07K16/18 , C12N15/11 , C12P21/02
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
Abstract translation: 描述了与Proprotein转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述了使用抗原结合蛋白质向PCSK9检测样品中PCSK9的量的方法。
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7.发明申请ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) 有权抗原蛋白质结合蛋白转移酶突变体KEXIN 9型（PCSK9）
公开(公告)号：US20120020976A1
公开(公告)日：2012-01-26
申请号：US13251955
申请日：2011-10-03
Applicant: Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC: A61K39/395 , A61P9/10 , C07K16/40
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
Abstract translation: 描述了与Proprotein转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述了使用抗原结合蛋白质向PCSK9检测样品中PCSK9的量的方法。
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公开(公告)号：US07695071B2
公开(公告)日：2010-04-13
申请号：US10688216
申请日：2003-10-15
Applicant: Eric Jackson , Hal Hirtz , James Dale , John Jordan , David Eddy , Simon Mark Jackson
Inventor： Eric Jackson , Hal Hirtz , James Dale , John Jordan , David Eddy , Simon Mark Jackson
IPC: E21C25/00
Abstract: The present invention is directed to an excavator that is operable in manual and automatic modes and uses state machines to effect unit operations, rotationally offset swing actuators to rotate boom and cutter head, a fail safe hydraulic system to maintain gripper pressure in the event of a malfunction of the hydraulic system, differing position and pressure control functions in the hydraulic actuators, a kinematic module to effect pitch and roll adjustments, a cutting face profile generator to generate a profile of the excavation face, and an optimization module to realize a high degree of optimization of excavator operation.
Abstract translation: 本发明涉及一种可在手动和自动模式下操作的挖掘机，并且使用状态机来实现单元操作，旋转地偏移摆动致动器以使悬臂和切割头旋转，故障安全液压系统在以下情况下保持夹持器压力 液压系统的故障，液压致动器中的不同的位置和压力控制功能，用于实现俯仰和滚动调节的运动模块，用于产生挖掘面的轮廓的切割面轮廓生成器，以及实现高度的优化模块 挖掘机运行优化。
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公开(公告)号：US20090326202A1
公开(公告)日：2009-12-31
申请号：US12474176
申请日：2009-05-28
Applicant: Simon Mark Jackson , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King
Inventor： Simon Mark Jackson , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King
IPC: C07K16/18
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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10.发明授权
公开(公告)号：US09994923B2
公开(公告)日：2018-06-12
申请号：US12989404
申请日：2009-02-20
Applicant: Simon Mark Jackson , Derek Evan Piper
Inventor： Simon Mark Jackson , Derek Evan Piper
IPC: A61K51/00 , A61K39/395 , A61K38/48 , C12N9/64 , A61K45/06 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K38/00
CPC classification number: C12Y304/21061 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K38/00 , A61K38/482 , A61K45/06 , C12N9/6454 , A61K2300/00
Abstract: Neutralizing PCSK9 variants that interact with low density lipoprotein receptor (LDLR) are described. Methods and compositions for treating disorders by administering a pharmaceutically effective amount of a neutralizing PCSK9 variant are described.
