Indirubin-3′-oxime derivatives as potent cyclin dependent kinase inhibitors
    3.
    发明授权
    Indirubin-3′-oxime derivatives as potent cyclin dependent kinase inhibitors 有权
    靛玉红-3'-肟衍生物作为有效的细胞周期蛋白依赖性激酶抑制剂

    公开(公告)号:US08859783B2

    公开(公告)日:2014-10-14

    申请号:US13576105

    申请日:2011-01-28

    CPC分类号: A61K31/404 C07D403/04

    摘要: The present invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor with anti-cancer activity. More particularly, this invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor having excellent anti-cancer activity against human lung cancer cell, human fibro sarcoma cell, human colon cancer cell, human leukemia cell, human stomach cancer cell, human nasopharyngeal cancer cell and/or human breast cancer cell.

    摘要翻译: 本发明涉及靛玉红-3'-肟衍生物作为具有抗癌活性的有效的细胞周期蛋白依赖性激酶抑制剂。 更具体地,本发明涉及靛玉红-3'-肟衍生物作为有效的细胞周期蛋白依赖性激酶抑制剂,其对人肺癌细胞,人纤维肉瘤细胞,人结肠癌细胞,人白血病细胞,人胃癌具有优异的抗癌活性 细胞,人鼻咽癌细胞和/或人乳腺癌细胞。