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11 条记录 (耗时 0.012 秒)

    Anti-sense nucleic acid derived from organism
    1.
    发明申请
    Anti-sense nucleic acid derived from organism 审中-公开
    来自生物体的反义核酸

    公开(公告)号：US20090209623A1

    公开(公告)日：2009-08-20

    申请号：US11989301

    申请日：2006-07-24

    申请人： Jon Tomono ,  Souichi Morikawa ,  Takahisa Nakai

    发明人： Jon Tomono ,  Souichi Morikawa ,  Takahisa Nakai

    IPC分类号： A61K31/7088 ,  C07H21/04 ,  A61K48/00

    CPC分类号： A61K8/606 ,  A61K31/7088 ,  A61K48/00 ,  A61Q5/00 ,  A61Q19/02 ,  A61Q19/08 ,  C12N15/111 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2330/30

    摘要： Disclosed are: a method for producing an anti-sense nucleic acid which has a wide variation in nucleotide sequences and excellent anti-sense properties at a low cost in a simple manner and in a large scale; and a cosmetic composition or pharmaceutical composition comprising the anti-sense nucleic acid. A method is discovered which can produce a low molecular weight nucleic acid having anti-sense properties from a nucleic acid starting material derived from an organism at a high yield by using a probe nucleic acid having at least a part of the nucleotide sequence of a target gene. An anti-sense nucleic acid produced by using a nucleic acid derived from an organism as a starting material; and a method for producing the anti-sense nucleic acid.

    摘要翻译： 本发明公开了以简单的方式和大规模生产具有较低成本的核苷酸序列变异性和抗反应性优异的反义核酸的方法。 以及包含所述反义核酸的化妆品组合物或药物组合物。 通过使用具有目标的核苷酸序列的至少一部分的探针核酸，发现能够以高产率从来自生物体的核酸起始物质产生具有反义性的低分子量核酸的方法 基因。 通过使用来自生物体的核酸作为起始原料而产生的反义核酸; 和反义核酸的制造方法。

    Peptide capable of binding to insulin-binding protein and adsorbent
    2.
    发明授权
    Peptide capable of binding to insulin-binding protein and adsorbent 有权
    能结合胰岛素结合蛋白和吸附剂的肽

    公开(公告)号：US07906618B2

    公开(公告)日：2011-03-15

    申请号：US11573834

    申请日：2005-08-09

    申请人： Ai Yonezawa ,  Souichi Morikawa ,  Eiji Ogino

    发明人： Ai Yonezawa ,  Souichi Morikawa ,  Eiji Ogino

    IPC分类号： A61K38/00 ,  A61K51/00

    CPC分类号： C07K14/62 ,  A61K47/585 ,  A61K47/6957 ,  C07K7/06

    摘要： The present invention relates to a peptide excellently capable of binding to a protein capable of binding to insulin (IBP), an adsorbent comprising the aforementioned peptide immobilized on a carrier, an adsorber comprising the aforementioned adsorbent, and a method of adsorbing IBPs by using the aforementioned adsorbent or adsorber.The peptide, adsorbent, adsorber and method provided by the present invention can selectively adsorb and remove IBPs efficiently, and therefore be used, for example, in the treatment of diseases, typically diabetes, in which such IBP acts as an aggravating factor.

    摘要翻译： 本发明涉及能够结合能够结合胰岛素（IBP）的蛋白质的肽，包含上述固定在载体上的肽的吸附剂，包含上述吸附剂的吸附剂，以及使用上述吸附剂吸附IBP的方法 上述吸附剂或吸附剂。 本发明提供的肽，吸附剂，吸附剂和方法可以有效吸附和去除IBP，因此可用于例如治疗这种IBP作为加重因素的疾病，通常为糖尿病。

    Heat shock factor activity inhibitor
    4.
    发明授权
    Heat shock factor activity inhibitor 失效
    热休克因子活性抑制剂

    公开(公告)号：US06613780B2

    公开(公告)日：2003-09-02

    申请号：US09939901

    申请日：2001-08-27

    申请人： Shin-ichi Yokota ,  Kozo Yamamoto ,  Souichi Morikawa ,  Yoshihide Fuse ,  Mikio Kitahara

    发明人： Shin-ichi Yokota ,  Kozo Yamamoto ,  Souichi Morikawa ,  Yoshihide Fuse ,  Mikio Kitahara

    IPC分类号： A61K31445

    CPC分类号： C07D405/06

    摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

    摘要翻译： 通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质的产生的抑制剂，其中 抑制热休克因子的活性，转录调节因子，从而进一步抑制基因区域中具有热休克元件序列的结构基因的转录，用于转录调节成RNA，从而抑制基因转化为蛋白质， 并导致抑制由该基因编码的RNA或蛋白质的产生。 它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。

    Peptide Capable Of Binding To Insulin-Binding Protein And Adsorbent
    7.
    发明申请
    Peptide Capable Of Binding To Insulin-Binding Protein And Adsorbent 有权
    能与胰岛素结合蛋白和吸附剂结合的肽

    公开(公告)号：US20080132679A1

    公开(公告)日：2008-06-05

    申请号：US11573834

    申请日：2005-08-09

    申请人： Ai Yonezawa ,  Souichi Morikawa ,  Eiji Ogino

    发明人： Ai Yonezawa ,  Souichi Morikawa ,  Eiji Ogino

    IPC分类号： C07K4/12 ,  B01D15/26 ,  B01J20/24 ,  C07K1/14

    CPC分类号： C07K14/62 ,  A61K47/585 ,  A61K47/6957 ,  C07K7/06

    摘要： The present invention relates to a peptide excellently capable of binding to a protein capable of binding to insulin (IBP), an adsorbent comprising the aforementioned peptide immobilized on a carrier, an adsorber comprising the aforementioned adsorbent, and a method of adsorbing IBPs by using the aforementioned adsorbent or adsorber.The peptide, adsorbent, adsorber and method provided by the present invention can selectively adsorb and remove IBPs efficiently, and therefore be used, for example, in the treatment of diseases, typically diabetes, in which such IBP acts as an aggravating factor.

    摘要翻译： 本发明涉及能够结合能够结合胰岛素（IBP）的蛋白质的肽，包含上述固定在载体上的肽的吸附剂，包含上述吸附剂的吸附剂，以及使用上述吸附剂吸附IBP的方法 上述吸附剂或吸附剂。 本发明提供的肽，吸附剂，吸附剂和方法可以有效吸附和去除IBP，因此可用于例如治疗这种IBP作为加重因素的疾病，通常为糖尿病。

    Methods of treating cancer using a heat shock factor activity inhibitor
    8.
    发明授权
    Methods of treating cancer using a heat shock factor activity inhibitor 失效
    使用热休克因子活性抑制剂治疗癌症的方法

    公开(公告)号：US06903116B2

    公开(公告)日：2005-06-07

    申请号：US10339063

    申请日：2003-01-09

    申请人： Shin-ichi Yokota ,  Kozo Yamamoto ,  Souichi Morikawa ,  Yoshihide Fuse ,  Mikio Kitahara

    发明人： Shin-ichi Yokota ,  Kozo Yamamoto ,  Souichi Morikawa ,  Yoshihide Fuse ,  Mikio Kitahara

    IPC分类号： C07D405/06 ,  A61K31/445 ,  A61K31/40

    CPC分类号： C07D405/06

    摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor.The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequenc in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

    摘要翻译： 通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。 新型化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质产生的抑制剂，其抑制热休克因子（转录调节因子）的活性，从而进而抑制转录 在基因区域中具有用于转录调节RNA的热休克元件的结构基因的结构基因，从而抑制基因翻译成蛋白质，并导致抑制由该基因编码的RNA或蛋白质的产生。 它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。