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公开(公告)号:US20060148800A1
公开(公告)日:2006-07-06
申请号:US11206703
申请日:2005-08-17
申请人: Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Zahn , Lars Herfurth
发明人: Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Zahn , Lars Herfurth
IPC分类号: A61K31/53
CPC分类号: C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要: The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
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公开(公告)号:US20050261295A1
公开(公告)日:2005-11-24
申请号:US11132091
申请日:2005-05-18
申请人: Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
发明人: Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
IPC分类号: C07D239/48 , C07D401/12 , C07D403/12 , C07D253/08 , A61K31/506 , A61K31/53 , C07D43/02
CPC分类号: C07D239/48 , C07D401/12 , C07D403/12
摘要: The present invention comprises compounds of general formula (1) wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中A,X,Y,Z,R a,O,R b,R c, R 1,R 2和R 3定义如权利要求1所述,其适用于治疗以过度或异常细胞为特征的疾病 增殖及其用于制备具有上述性质的药物组合物的用途。
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公开(公告)号:US20070207999A1
公开(公告)日:2007-09-06
申请号:US11675936
申请日:2007-02-16
申请人: Heinz Stadtmueller , Anke Baum , Guido Boehmelt , Harald Engelhardt , Jens Quant , Flavio Solca , Martin Steegmaier , Stephan Zahn
发明人: Heinz Stadtmueller , Anke Baum , Guido Boehmelt , Harald Engelhardt , Jens Quant , Flavio Solca , Martin Steegmaier , Stephan Zahn
IPC分类号: A61K31/55 , A61K31/553 , C07D403/02 , C07D413/02
CPC分类号: C07D498/04 , C07D403/12 , C07D413/12 , C07D487/04
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R6, X and Y are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, as well as the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译: 本发明包括其中R 1至R 6的通式(1)的化合物,X和Y如权利要求1中所定义,其适用于治疗疾病 其特征在于过度或异常的细胞增殖,以及其用于制备具有上述性质的药物组合物的用途。
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公开(公告)号:US20070032514A1
公开(公告)日:2007-02-08
申请号:US11475468
申请日:2006-06-27
申请人: Stephan Zahn , Guido Boehmelt , Andreas Mantoulidis , Ulrich Reiser , Matthias Treu , Ulrich Guertler , Andreas Schoop , Flavio Solca , Ulrike Tontsch-Grunt , Ralph Brueckner , Charlotte Reither , Lars Herfurth , Oliver Kraemer , Heinz Stadtmueller , Harald Engelhardt
发明人: Stephan Zahn , Guido Boehmelt , Andreas Mantoulidis , Ulrich Reiser , Matthias Treu , Ulrich Guertler , Andreas Schoop , Flavio Solca , Ulrike Tontsch-Grunt , Ralph Brueckner , Charlotte Reither , Lars Herfurth , Oliver Kraemer , Heinz Stadtmueller , Harald Engelhardt
IPC分类号: A61K31/505 , C07D239/38
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D487/08
摘要: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3定义如权利要求1,其适用于治疗以过量或 异常细胞增殖,以及其用于制备具有上述性质的药物组合物的用途。
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