-
1.发明申请NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF 有权萘磺隆化合物展示丙烯酸羟化酶抑制活性，组合物及其用途公开(公告)号：US20100048572A1
公开(公告)日：2010-02-25
申请号：US12612465
申请日：2009-11-04
Applicant: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
Inventor： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC: A61K31/535 , A61K31/435 , A61K31/438 , A61K31/35 , A61K31/34 , A61K31/195
CPC classification number: C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
Abstract: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
Abstract translation: 式I和式II的化合物可用作HIF脯氨酰羟化酶的抑制剂。 式I和式II的化合物具有以下结构：其中本文提供变量的定义。
-
2.发明申请Azaquinolone based compounds exhibiting prolyl hydroxylase Inhibitory activity, compositions, and uses thereof 有权显示脯氨酰羟化酶抑制活性的组合物及其用途的基于喹唑酮酮的化合物
公开(公告)号：US20090111806A1
公开(公告)日：2009-04-30
申请号：US12002538
申请日：2007-12-17
Applicant: Jennifer R. Allen , Kaustav Biswas , Guo-Qiang Cao , Jennifer E. Golden , Stephanie Mercede , Tanya Peterkin , Anthony Reed , Christopher M. Tegley
Inventor： Jennifer R. Allen , Kaustav Biswas , Guo-Qiang Cao , Jennifer E. Golden , Stephanie Mercede , Tanya Peterkin , Anthony Reed , Christopher M. Tegley
IPC: A61K31/4375 , C07D471/04 , A61K31/5377 , A61P7/06 , A61P37/00 , A61P9/10 , A61P9/12 , A61P29/00 , C07D413/10
CPC classification number: C07D471/04
Abstract: are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein.
Abstract translation: 可用作HIF脯氨酰羟化酶的抑制剂，其中本文提供变量的定义。
-
3.发明授权Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof 有权显示脯氨酰羟化酶抑制活性的氮卓喹酮基化合物及其用途
公开(公告)号：US08048892B2
公开(公告)日：2011-11-01
申请号：US12002538
申请日：2007-12-17
Applicant: Jennifer R. Allen , Kaustav Biswas , Guo-Qiang Cao , Jennifer E. Golden , Stephanie Mercede , Tanya Peterkin , Anthony Reed , Christopher M. Tegley
Inventor： Jennifer R. Allen , Kaustav Biswas , Guo-Qiang Cao , Jennifer E. Golden , Stephanie Mercede , Tanya Peterkin , Anthony Reed , Christopher M. Tegley
IPC: A61K31/4375 , C07D471/04
CPC classification number: C07D471/04
Abstract: are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein.
Abstract translation: 可用作HIF脯氨酰羟化酶的抑制剂，其中本文提供变量的定义。
-
公开(公告)号：US20090099171A1
公开(公告)日：2009-04-16
申请号：US12150998
申请日：2008-05-02
Applicant: Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer E. Golden , Stephanie Mercede , Christopher M. Tegley
Inventor： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer E. Golden , Stephanie Mercede , Christopher M. Tegley
IPC: A61K31/5377 , C07D487/02 , A61K31/5025 , C12N5/00 , A61K31/4985 , A61P37/06 , A61P35/00 , A61P9/00 , A61P29/00 , A61P17/02 , C07D471/02 , A61K31/519 , C07D413/14
CPC classification number: C07D471/04
Abstract: Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式I化合物是HIF脯氨酰羟化酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。
-
5.发明授权Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof 有权显示脯氨酰羟化酶抑制活性的萘环酮化合物，组合物和用途
公开(公告)号：US07928139B2
公开(公告)日：2011-04-19
申请号：US12612465
申请日：2009-11-04
Applicant: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
Inventor： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC: A61K31/352 , A61K31/195
CPC classification number: C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
Abstract: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
Abstract translation: 式I和式II的化合物可用作HIF脯氨酰羟化酶的抑制剂。 式I和式II的化合物具有以下结构：其中本文提供变量的定义。
-
6.发明授权Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof 有权显示脯氨酰羟化酶抑制活性的萘环酮化合物，组合物和用途
公开(公告)号：US07635715B2
公开(公告)日：2009-12-22
申请号：US12002537
申请日：2007-12-17
Applicant: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
Inventor： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC: A61K31/352 , C07D311/96
CPC classification number: C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
Abstract: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
Abstract translation: 式I和式II的化合物可用作HIF脯氨酰羟化酶的抑制剂。 式I和式II的化合物具有以下结构：其中本文提供变量的定义。
-
公开(公告)号：US20090093483A1
公开(公告)日：2009-04-09
申请号：US12002537
申请日：2007-12-17
Applicant: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
Inventor： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC: A61K31/5375 , C07D265/30 , A61K31/352 , C07D311/96 , C07C229/34 , A61K31/197 , A61K31/4418 , C07D213/56 , A61P9/10 , C12N5/06
CPC classification number: C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
Abstract: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
-
8.发明申请Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof 有权具有脯氨酰羟化酶抑制活性的喹诺酮类化合物及其组合物及其用途
公开(公告)号：US20070249605A1
公开(公告)日：2007-10-25
申请号：US11635683
申请日：2006-12-08
Applicant: Jennifer Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael Frohn , Jennifer Golden , Randall Hungate , Robert Kurzeja , Stephanie Mercede , Kristine Muller , Susana Neira , Tanya Peterkin , Christopher Tegley , Violeta Yu
Inventor： Jennifer Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael Frohn , Jennifer Golden , Randall Hungate , Robert Kurzeja , Stephanie Mercede , Kristine Muller , Susana Neira , Tanya Peterkin , Christopher Tegley , Violeta Yu
IPC: A61K31/47 , A61K31/495 , A61K31/506 , A61K31/5377 , A61P35/00 , A61P5/00 , A61P7/00 , A61P9/00 , C07D215/00 , C07D237/02 , C07D239/02 , C07D265/30 , G01N33/53
CPC classification number: C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
Abstract: This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
Abstract translation: 本发明涉及显示脯氨酰羟化酶抑制活性的新型喹诺酮类化合物。 本发明还涉及通过向受试者施用至少一种基于喹诺酮的化合物来增加受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。 本发明还涉及用于检测HIF分子中的羟脯氨酸残基的测定法。
-
公开(公告)号：US08097620B2
公开(公告)日：2012-01-17
申请号：US12150998
申请日：2008-05-02
Applicant: Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer E. Golden , Stephanie Mercede , Christopher M. Tegley
Inventor： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer E. Golden , Stephanie Mercede , Christopher M. Tegley
IPC: C07D471/04 , C07D413/14 , A61K31/519 , A61K31/5355 , A61P3/10 , A61P35/00 , A61P29/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式I化合物是HIF脯氨酰羟化酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。
