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    Pancreatic Cancer Biomarkers and Uses Thereof
    1.
    发明申请
    Pancreatic Cancer Biomarkers and Uses Thereof 审中-公开
    胰腺癌生物标志物及其用途

    公开(公告)号：US20120040861A1

    公开(公告)日：2012-02-16

    申请号：US13208903

    申请日：2011-08-12

    申请人： Stephen Alaric Williams ,  Michael Riel-Mehan ,  Rachel M. Ostroff

    发明人： Stephen Alaric Williams ,  Michael Riel-Mehan ,  Rachel M. Ostroff

    IPC分类号： C40B30/04 ,  G06F19/00

    CPC分类号： G01N33/6893 ,  G01N33/57438 ,  G16B20/00

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and pancreatic cancer specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or pancreatic cancer specifically. In another aspect, methods are provided for diagnosing pancreatic cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having pancreatic cancer, or the likelihood of the individual having pancreatic cancer is determined, based on the at least one biomarker value. In a further aspect, methods are provided for diagnosing cancer generally in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer generally, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本公开内容包括用于癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒，特别是胰腺癌。 在一个方面，本公开提供可以单独使用或以各种组合使用的生物标志物，以特异性诊断癌症或胰腺癌。 在另一方面，提供了用于诊断个体中的胰腺癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值 ，其中基于所述至少一种生物标志物值将所述个体分类为具有胰腺癌或确定具有胰腺癌的个体的可能性。 在另一方面，提供了用于一般在个体中诊断癌症的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于至少一种选自表中提供的生物标志物的生物标志物的生物标记值 19，其中，基于所述至少一种生物标记值，将所述个体一般分类为具有癌症或确定患有癌症的个体的可能性。

    Lung Cancer Biomarkers and Uses Thereof
    3.
    发明申请
    Lung Cancer Biomarkers and Uses Thereof 审中-公开
    肺癌生物标志物及其用途

    公开(公告)号：US20120101002A1

    公开(公告)日：2012-04-26

    申请号：US13279990

    申请日：2011-10-24

    申请人： Michael Riel-Mehan ,  Alex A.E. Stewart ,  Rachel M. Ostroff ,  Stephen Alaric Williams ,  Edward N. Brody

    发明人： Michael Riel-Mehan ,  Alex A.E. Stewart ,  Rachel M. Ostroff ,  Stephen Alaric Williams ,  Edward N. Brody

    IPC分类号： C40B30/04 ,  G06F19/24 ,  C40B40/10

    CPC分类号： G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/16 ,  G01N33/57423 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00 ,  G16B99/00

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of non-small cell lung cancer and general cancer. In one aspect, methods are provided for diagnosing non-small cell lung cancer, where the methods include detecting, in a sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having lung cancer, or the likelihood of having lung cancer is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer, where the methods include detecting, in a sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 19, wherein an individual is classified as having cancer, or the likelihood of having cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本公开包括用于非小细胞肺癌和一般癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，提供了用于诊断非小细胞肺癌的方法，其中所述方法包括在样品中检测对应于选自表1中提供的生物标志物的至少一种生物标志物的至少一种生物标志物值，其中个体为 基于所述至少一种生物标志物值，确定分类为具有肺癌或确定患有肺癌的可能性。 在另一方面，提供了用于诊断癌症的方法，其中所述方法包括在样品中检测对应于选自表19中提供的生物标志物的至少一种生物标志物的至少一种生物标志物值，其中个体被分类为具有癌症， 或者基于所述至少一种生物标志物值确定患有癌症的可能性。

    Mesothelioma Biomarkers and Uses Thereof
    6.
    发明申请
    Mesothelioma Biomarkers and Uses Thereof 审中-公开
    间皮瘤生物标志物及其用途

    公开(公告)号：US20120077695A1

    公开(公告)日：2012-03-29

    申请号：US13246388

    申请日：2011-09-27

    申请人： Rachel M. Ostroff ,  Alex A.E. Stewart ,  Stephen Alaric Williams ,  Edward N. Brody ,  Malti Nikrad ,  Michael Riel-Mehan

    发明人： Rachel M. Ostroff ,  Alex A.E. Stewart ,  Stephen Alaric Williams ,  Edward N. Brody ,  Malti Nikrad ,  Michael Riel-Mehan

    IPC分类号： C40B30/04 ,  C40B40/10

    CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2800/50

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, methods are provided for diagnosing mesothelioma where the methods include detecting, in a biological sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having mesothelioma, or the likelihood of an individual having mesothelioma is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer generally where the methods include detecting, in a biological sample at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 17, wherein an individual is classified as having cancer generally, or the likelihood of an individual having cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本公开包括用于癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，提供了用于诊断间皮瘤的方法，其中所述方法包括在生物样品中检测对应于选自表1中提供的生物标志物的至少一种生物标志物的至少一种生物标记值，其中个体被分类为具有间皮瘤， 或者基于所述至少一种生物标志物值确定个体具有间皮瘤的可能性。 在另一方面，提供了用于诊断癌症的方法，其中所述方法包括在生物样品中检测对应于选自表17中提供的生物标志物的至少一种生物标志物的至少一种生物标记值，其中个体被分类为具有癌症 或者确定个体患有癌症的可能性，基于至少一种生物标志物值。