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公开(公告)号:US09856204B2
公开(公告)日:2018-01-02
申请号:US13698645
申请日:2011-05-19
IPC分类号: C07C61/29 , A61K31/19 , A61K31/191 , A61K31/198 , A61K31/215 , C07C69/12 , C07C69/757 , C07C235/82 , C07D265/30 , C07J53/00
CPC分类号: C07C61/29 , A61K31/19 , A61K31/191 , A61K31/198 , A61K31/215 , C07C69/12 , C07C69/757 , C07C235/82 , C07D265/30 , C07J53/002
摘要: In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号:US20160243132A1
公开(公告)日:2016-08-25
申请号:US15051246
申请日:2016-02-23
IPC分类号: A61K31/58 , A61K31/353 , C12Q1/68 , A61K31/473 , A61K31/407 , G01N33/50 , A61K31/56 , A61K31/4166
CPC分类号: A61K31/58 , A61K31/215 , A61K31/352 , A61K31/353 , A61K31/36 , A61K31/382 , A61K31/404 , A61K31/407 , A61K31/4164 , A61K31/4166 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/4706 , A61K31/473 , A61K31/56 , A61K31/565 , C12Q1/6809 , C12Q2600/136 , G01N33/5023 , G01N2800/10 , G01N2800/52 , A61K2300/00
摘要: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译: 一方面,本发明涉及通过向有需要的动物提供有效量的化合物来治疗肌肉萎缩的方法。 该化合物可以调节肌肉萎缩特征的多个mRNA的表达水平。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具,而不意在限制本发明。
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公开(公告)号:US09295664B2
公开(公告)日:2016-03-29
申请号:US14124582
申请日:2012-06-06
IPC分类号: A61K31/58 , A61K31/565 , A61K31/353 , A61K31/435 , A61K31/4166 , A61K31/473 , A61K31/407 , C12Q1/68 , A61K31/436 , A61K31/215 , A61K31/352 , A61K31/36 , A61K31/382 , A61K31/404 , A61K31/4164 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/4706 , A61K31/56 , G01N33/50
CPC分类号: A61K31/58 , A61K31/215 , A61K31/352 , A61K31/353 , A61K31/36 , A61K31/382 , A61K31/404 , A61K31/407 , A61K31/4164 , A61K31/4166 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/4706 , A61K31/473 , A61K31/56 , A61K31/565 , C12Q1/6809 , C12Q2600/136 , G01N33/5023 , G01N2800/10 , G01N2800/52 , A61K2300/00
摘要: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译: 一方面,本发明涉及通过向有需要的动物提供有效量的化合物来治疗肌肉萎缩的方法。 该化合物可以调节肌肉萎缩特征的多个mRNA的表达水平。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具,而不意在限制本发明。
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公开(公告)号:US20140228333A1
公开(公告)日:2014-08-14
申请号:US14124582
申请日:2012-06-06
IPC分类号: A61K31/58 , A61K31/353 , C12Q1/68 , A61K31/4166 , A61K31/473 , A61K31/407 , A61K31/565 , A61K31/435
CPC分类号: A61K31/58 , A61K31/215 , A61K31/352 , A61K31/353 , A61K31/36 , A61K31/382 , A61K31/404 , A61K31/407 , A61K31/4164 , A61K31/4166 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/4706 , A61K31/473 , A61K31/56 , A61K31/565 , C12Q1/6809 , C12Q2600/136 , G01N33/5023 , G01N2800/10 , G01N2800/52 , A61K2300/00
摘要: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译: 一方面,本发明涉及通过向有需要的动物提供有效量的化合物来治疗肌肉萎缩的方法。 该化合物可以调节肌肉萎缩特征的多个mRNA的表达水平。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具,而不意在限制本发明。
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公开(公告)号:US20130203712A1
公开(公告)日:2013-08-08
申请号:US13698645
申请日:2011-05-19
IPC分类号: C07C61/29 , C07C235/82 , C07C69/12 , C07D265/30 , C07C69/757 , C07J53/00
CPC分类号: C07C61/29 , A61K31/19 , A61K31/191 , A61K31/198 , A61K31/215 , C07C69/12 , C07C69/757 , C07C235/82 , C07D265/30 , C07J53/002
摘要: In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译: 一方面,本发明涉及通过向有需要的受试者提供有效量的熊果酸,其衍生物或尿烷支架的类似物来抑制或预防肌肉萎缩或增加肌肉质量的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具,而不意在限制本发明。
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