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![5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors](/abs-image/US/2013/09/10/US08530489B2/abs.jpg.150x150.jpg)
1.发明授权5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors 有权可用作蛋白激酶抑制剂的5-氰基-4-（吡咯并[2,3B]吡啶-3-基） - 嘧啶衍生物公开(公告)号：US08530489B2
公开(公告)日：2013-09-10
申请号：US13477663
申请日：2012-05-22
Applicant: Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
Inventor： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
IPC: A01N43/54 , A61K31/505
CPC classification number: C07D471/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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![5-CYANO-4- (PYRROLO [2,3B] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS](/abs-image/US/2012/12/06/US20120309963A1/abs.jpg.150x150.jpg)
2.发明申请5-CYANO-4- (PYRROLO [2,3B] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS 有权5-氰基-4-（吡咯并[2,3B]吡啶-3-基） - 吡啶衍生物，用作蛋白激酶抑制剂公开(公告)号：US20120309963A1
公开(公告)日：2012-12-06
申请号：US13477663
申请日：2012-05-22
Applicant: Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
Inventor： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US07915305B2
公开(公告)日：2011-03-29
申请号：US11656876
申请日：2007-01-23
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC: A61K31/38
CPC classification number: C07D471/04 , C07D487/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase represented by formula (I): or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作由式（I）表示的蛋白激酶抑制剂的化合物或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20090286840A1
公开(公告)日：2009-11-19
申请号：US11786579
申请日：2007-04-12
Applicant: Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
Inventor： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC: A61K31/4178 , C07D409/04 , A61K31/4155 , A61P35/00 , A61P25/00 , A61P29/00 , A61P3/10
CPC classification number: C07D409/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20070155718A1
公开(公告)日：2007-07-05
申请号：US11489939
申请日：2006-07-20
Applicant: Steven Durrant , Jean-Damien Charrier , John Studley
Inventor： Steven Durrant , Jean-Damien Charrier , John Studley
IPC: A61K31/55 , A61K31/5513 , A61K31/503 , A61K31/517 , A61K31/513 , A61K31/4745 , A61K31/424 , C07D491/04
CPC classification number: C07D498/04
Abstract: This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors. This invention also relates to the processes for preparing these prodrugs of caspase inhibitors. This invention further relates to pharmaceutical compositions comprising said prodrugs and to the use thereof for the treatment of diseases related to inflammatory or degenerative conditions.
Abstract translation: 本发明涉及包含呋喃并[3,2-d]恶唑啉-5-酮部分的胱天蛋白酶抑制剂的前体药物，其在特定条件下可转化为生物活性化合物，特别是胱天蛋白酶抑制剂。 本发明还涉及制备这些半胱天冬酶抑制剂前药的方法。 本发明还涉及包含所述前药的药物组合物及其用于治疗与炎性或退行性疾病相关的疾病的用途。
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Patent Agency Ranking
6.发明授权Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors 有权制备可用作蛋白激酶抑制剂的嘧啶衍生物的方法公开(公告)号：US08592577B2
公开(公告)日：2013-11-26
申请号：US13497139
申请日：2012-03-20
Applicant: Jean-Damien Charrier , Steven Durrant , Michael O'Donnell
Inventor： Jean-Damien Charrier , Steven Durrant , Michael O'Donnell
IPC: C07D475/00 , C07D475/10 , C07D487/04
CPC classification number: C07D475/00 , C07D475/10 , C07D487/04
Abstract: A method of preparing a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and claims. Additionally, the present invention relates to compounds of Structural Formula (I), which are useful as inhibitors of protein kinase.
Abstract translation: 制备由结构式（I）表示的化合物或其药学上可接受的盐的方法，其中结构式（I）的变量如说明书和权利要求书中所述。 另外，本发明涉及结构式（I）的化合物，其可用作蛋白激酶的抑制剂。
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公开(公告)号：US08481578B2
公开(公告)日：2013-07-09
申请号：US13234332
申请日：2011-09-16
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily
IPC: A61K31/4196 , C07D249/12
CPC classification number: C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US08399458B2
公开(公告)日：2013-03-19
申请号：US12903390
申请日：2010-10-13
Applicant: Ronald Knegtel , Jean-Damien Charrier , Steven Durrant , Guy Brenchley , Michael Mortimore
Inventor： Ronald Knegtel , Jean-Damien Charrier , Steven Durrant , Guy Brenchley , Michael Mortimore
IPC: C07D495/04 , C07D513/04 , C07D519/00 , A61K31/4188 , A61K31/4184 , A61K31/55
CPC classification number: C07D513/04 , A61K31/55 , A61K31/551 , A61K45/06 , C07D495/04 , C07D519/00 , C07K14/81
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20120322793A1
公开(公告)日：2012-12-20
申请号：US13593674
申请日：2012-08-24
Applicant: Jean-Damien Charrier , Steven Durrant
Inventor： Jean-Damien Charrier , Steven Durrant
IPC: A61K31/551 , C07D487/16 , A61P35/04 , A61P25/28 , C12N9/99 , A61P19/00 , A61P7/00 , A61P35/02 , A61P37/00 , A61P31/12 , C07D487/04 , A61P1/16
CPC classification number: C07D487/04
Abstract: In one aspect, the invention provides compounds of Formula I or pharmaceutically acceptable salts thereof. In another aspect, the invention provides methods for treatment of diseases or disorders mediated by a protein kinase, comprising administering a therapeutically effective amount of a compound of this invention.
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公开(公告)号：US08101770B2
公开(公告)日：2012-01-24
申请号：US11304057
申请日：2005-12-15
Applicant: Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
Inventor： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
IPC: C07D401/00 , A61K31/44
CPC classification number: C07D401/14 , C07D213/22 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention and intermediate compounds useful in these processes.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法和用于这些方法的中间体化合物。
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