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公开(公告)号:US08604193B2
公开(公告)日:2013-12-10
申请号:US13146151
申请日:2010-01-26
IPC分类号: C07D239/10
CPC分类号: C07D239/545 , A61K31/505 , C07C255/57 , C07C275/50 , C07D233/60 , C07D239/54 , C07D239/553
摘要: Disclosed is a method for preparing HIV reverse transcriptase inhibitors which inhibit replication of HIV in HIV infected cells, and novel intermediate compounds used therein.
摘要翻译: 公开了一种制备抑制HIV感染细胞中HIV复制的HIV逆转录酶抑制剂的方法及其中所用的新型中间体化合物。
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公开(公告)号:US20120238758A1
公开(公告)日:2012-09-20
申请号:US13413518
申请日:2012-03-06
申请人: Eric Dowdy , Steven Pfeiffer
发明人: Eric Dowdy , Steven Pfeiffer
IPC分类号: C07D215/56
CPC分类号: C07D215/56 , C07C41/18 , C07C41/30 , C07C51/15 , C07C51/377 , C07C67/343 , C07C227/00 , C07C65/24 , C07C69/738 , C07C229/34 , C07C43/23 , C07C43/225
摘要: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
摘要翻译: 本发明提供可用于制备具有有用的整合酶抑制性质的4-氧喹诺酮化合物的合成方法和合成中间体。
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公开(公告)号:US20120022257A1
公开(公告)日:2012-01-26
申请号:US13146151
申请日:2010-01-26
IPC分类号: C07D239/545 , C07C255/56 , C07D233/61 , C07C255/30 , C07D239/54
CPC分类号: C07D239/545 , A61K31/505 , C07C255/57 , C07C275/50 , C07D233/60 , C07D239/54 , C07D239/553
摘要: Disclosed is a method for preparing HIV reverse transcriptase inhibitors which inhibit replication of HIV in HIV infected cells, and novel intermediate compounds used therein.
摘要翻译: 公开了一种制备抑制HIV感染细胞中HIV复制的HIV逆转录酶抑制剂的方法及其中所用的新型中间体化合物。
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公开(公告)号:US20120296076A1
公开(公告)日:2012-11-22
申请号:US13475569
申请日:2012-05-18
申请人: Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Duc-Phi Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
发明人: Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Duc-Phi Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
CPC分类号: C07H19/20 , C07D473/34 , C07F9/4075 , C07F9/4449 , C07F9/65616 , C07H19/02 , C07H19/04 , C07H19/16 , C07H19/173 , C07H23/00
摘要: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
摘要翻译: 本发明提供可用于制备具有有效抗HIV特性的化合物的合成方法和合成中间体。
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公开(公告)号:US08119800B2
公开(公告)日:2012-02-21
申请号:US12336762
申请日:2008-12-17
申请人: Hongyan Guo , Stacey Heumann , Ill Young Lee , Michael L. Mitchell , Steven Pfeiffer , Jong Chan Son
发明人: Hongyan Guo , Stacey Heumann , Ill Young Lee , Michael L. Mitchell , Steven Pfeiffer , Jong Chan Son
IPC分类号: C07D239/02
CPC分类号: C07D239/54
摘要: Compounds of Formula (I): can be prepared by a multi-step process from compounds of Formula (II): wherein G is Cl, Br or I.
摘要翻译: 式(I)化合物:可以通过式(II)化合物的多步法制备:其中G是Cl,Br或I.
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公开(公告)号:US20080125594A1
公开(公告)日:2008-05-29
申请号:US11853606
申请日:2007-09-11
申请人: Eric Dowdy , Xi Chen , Steven Pfeiffer
发明人: Eric Dowdy , Xi Chen , Steven Pfeiffer
IPC分类号: C07D215/233 , C07C65/05 , C07D233/14
CPC分类号: C07D215/56 , C07C41/28 , C07C41/30 , C07C43/225 , C07C43/23 , C07C51/367 , C07C51/377 , C07C65/24 , C07C67/18 , C07C67/343 , C07C227/10 , C07C227/16 , C07C227/18 , C07D233/54 , C07D233/60 , C07C69/738 , C07C229/34
摘要: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
摘要翻译: 本发明提供可用于制备具有有用的整合酶抑制性质的4-氧喹诺酮化合物的合成方法和合成中间体。
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公开(公告)号:US08987437B2
公开(公告)日:2015-03-24
申请号:US13475569
申请日:2012-05-18
申请人: Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Duc-Phi Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
发明人: Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Duc-Phi Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
IPC分类号: C07H19/00 , C07F9/6561 , C07D473/34 , C07F9/40 , C07F9/44 , C07H19/20 , C07H19/16 , C07H23/00
CPC分类号: C07H19/20 , C07D473/34 , C07F9/4075 , C07F9/4449 , C07F9/65616 , C07H19/02 , C07H19/04 , C07H19/16 , C07H19/173 , C07H23/00
摘要: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
摘要翻译: 本发明提供可用于制备具有有效抗HIV特性的化合物的合成方法和合成中间体。
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公开(公告)号:US08497396B2
公开(公告)日:2013-07-30
申请号:US12752639
申请日:2010-04-01
申请人: Richard Polniaszek , Steven Pfeiffer , Richard Yu , Aaron Cullen , Eric Dowdy , Duong Tran , Kenneth Kent , Zhongxin Zhou , Doug Cordeau , Leah Easton
发明人: Richard Polniaszek , Steven Pfeiffer , Richard Yu , Aaron Cullen , Eric Dowdy , Duong Tran , Kenneth Kent , Zhongxin Zhou , Doug Cordeau , Leah Easton
IPC分类号: C07C307/06 , C07D413/14
CPC分类号: C07D277/30 , C07C209/62 , C07C209/70 , C07C303/34 , C07C307/02 , C07C307/06 , C07D277/28 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , Y02P20/55 , C07C211/27 , C07C211/28
摘要: The invention provides methods and intermediates that are useful for preparing a compound of formula I: and salts thereof.
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公开(公告)号:US08324244B2
公开(公告)日:2012-12-04
申请号:US12892682
申请日:2010-09-28
申请人: Eric Dowdy , Xi Chen , Steven Pfeiffer
发明人: Eric Dowdy , Xi Chen , Steven Pfeiffer
IPC分类号: A61K31/47 , A61K31/4174 , A61K31/216 , C07D215/20 , C07D233/20 , C07C69/773
CPC分类号: C07D215/56 , C07C41/28 , C07C41/30 , C07C43/225 , C07C43/23 , C07C51/367 , C07C51/377 , C07C65/24 , C07C67/18 , C07C67/343 , C07C227/10 , C07C227/16 , C07C227/18 , C07D233/54 , C07D233/60 , C07C69/738 , C07C229/34
摘要: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
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公开(公告)号:US20110160458A1
公开(公告)日:2011-06-30
申请号:US12892682
申请日:2010-09-28
申请人: Eric Dowdy , Xi Chen , Steven Pfeiffer
发明人: Eric Dowdy , Xi Chen , Steven Pfeiffer
IPC分类号: C07D215/56 , C07C43/225 , C07C41/30 , C07C69/716 , C07C65/21
CPC分类号: C07D215/56 , C07C41/28 , C07C41/30 , C07C43/225 , C07C43/23 , C07C51/367 , C07C51/377 , C07C65/24 , C07C67/18 , C07C67/343 , C07C227/10 , C07C227/16 , C07C227/18 , C07D233/54 , C07D233/60 , C07C69/738 , C07C229/34
摘要: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
摘要翻译: 本发明提供可用于制备具有有用的整合酶抑制性质的4-氧喹诺酮化合物的合成方法和合成中间体。
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