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    Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
    1.
    发明授权
    Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders 有权
    取代的三环酸衍生物作为可用于治疗自身免疫性和炎症性疾病的S1P1受体激动剂

    公开(公告)号：US08415484B2

    公开(公告)日：2013-04-09

    申请号：US13060477

    申请日：2009-08-26

    申请人： Robert M. Jones ,  Daniel J. Buzard ,  Andrew M. Kawasaki ,  Sun Hee Kim ,  Lars Thoresen ,  Juerg Lehmann ,  Xiuwen Zhu

    发明人： Robert M. Jones ,  Daniel J. Buzard ,  Andrew M. Kawasaki ,  Sun Hee Kim ,  Lars Thoresen ,  Juerg Lehmann ,  Xiuwen Zhu

    IPC分类号： C07D403/02 ,  C07D487/00 ,  C07D471/14 ,  C07D487/12 ,  C07D401/00 ,  C07D403/14 ,  A61K31/44 ,  A61K31/415 ,  A61K31/40

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： The present invention relates to certain substituted tricyclic acid derivatives of Formula (I) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, myocardial ischemia-reperfusion injury, hypertensive nephropathy, glomerulosclerosis, gastritis, polymyositis, thyroiditis, vitiligo, hepatitis, biliary cirrhosis, microbial infections and associated diseases, viral infections and associated diseases, diseases and disorders mediated by lymphocytes, auto immune diseases, inflammatory diseases, and cancer.

    摘要翻译： 本发明涉及某些取代的式（I）的三环酸衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如作为S1P1受体的激动剂。 本发明还提供了含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗S1P1相关病症的方法，例如牛皮癣，类风湿性关节炎，克罗恩病，移植排斥反应，多发性 硬化症，系统性红斑狼疮，溃疡性结肠炎，I型糖尿病，痤疮，心肌缺血再灌注损伤，高血压肾病，肾小球硬化，胃炎，多发性肌炎，甲状腺炎，白癜风，肝炎，胆汁性肝硬化，微生物感染和相关疾病，病毒感染和相关疾病 ，由淋巴细胞介导的疾病和病症，自身免疫疾病，炎性疾病和癌症。

    WIRELESS COMMUNICATION SYSTEM AND APPARATUS FOR MANAGING AN UNDERGROUND FACILITY
    5.
    发明申请
    WIRELESS COMMUNICATION SYSTEM AND APPARATUS FOR MANAGING AN UNDERGROUND FACILITY 审中-公开
    无线通信系统和管理地下设施的设备

    公开(公告)号：US20100227557A1

    公开(公告)日：2010-09-09

    申请号：US12718522

    申请日：2010-03-05

    申请人： Yun-Jae WON ,  Seung-Ok Lim ,  Sun-Hee Kim ,  Jin-Woong Cho

    发明人： Yun-Jae WON ,  Seung-Ok Lim ,  Sun-Hee Kim ,  Jin-Woong Cho

    IPC分类号： H04B7/005

    CPC分类号： H04Q9/00 ,  H04Q2209/43 ,  H04Q2209/50 ,  H04Q2209/60 ,  H04Q2209/84 ,  H04Q2209/883

    摘要： A wireless communication system for managing an underground facility includes: at least one sensor node attached to the underground facility configured to transmit a sensing signal via magnetic field communication after detecting the status information of the underground facility in accordance with a driving signal, the driving signal comprising a wake-up signal; and an information collection device configured to: transmit the driving signal to the sensor node; collect the sensing signal transmitted from the sensor node; and transmit the collected information to a monitoring system via short-range wireless communication.

    摘要翻译： 一种用于管理地下设施的无线通信系统包括：附接到地下设施的至少一个传感器节点，其被配置为根据驱动信号检测到地下设施的状态信息之后通过磁场通信传输感测信号，驱动信号 包括唤醒信号; 以及信息收集装置，被配置为：将所述驱动信号发送到所述传感器节点; 收集从传感器节点发送的感测信号; 并通过短距离无线通信将收集的信息发送到监控系统。

    STABLE LIQUID COMPOSITIONS FOR TREATING STOMATITIS COMPRISING EPIDERMAL GROWTH FACTOR
    7.
    发明申请
    STABLE LIQUID COMPOSITIONS FOR TREATING STOMATITIS COMPRISING EPIDERMAL GROWTH FACTOR 有权
    稳定液体组合物，用于处理包含生物生长因子的STOMATITI

    公开(公告)号：US20100035809A1

    公开(公告)日：2010-02-11

    申请号：US12444961

    申请日：2007-10-09

    申请人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

    发明人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

    IPC分类号： A61K38/18

    CPC分类号： A61K9/006 ,  A61K38/1808 ,  A61K47/10 ,  C07K14/485

    摘要： Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.

    摘要翻译： 本发明提供一种用于治疗口腔炎的液体组合物，该液体组合物包括：表皮生长因子; 粘合剂聚合物; 和选自乙二胺四乙酸（EDTA）及其盐，组氨酸，赖氨酸及其无机酸盐，精氨酸及其无机酸盐和右旋糖酐的至少一种稳定剂。 液体组合物包括选自EDTA（或其盐）和某些氨基酸（或其无机酸盐）的稳定剂，因此可以显着增加表皮生长因子的物理化学和生物学稳定性。 因此，液体组合物可以长期储存和分配。 稳定化的组合物包括粘合剂聚合物，因此当以使用者口中喷雾形式喷射时，液体组合物可以快速地附着于炎症部位并且长时间显示出有效性。

    Compositions for inhibition of necrosis induced by a neurotrophin
    8.
    发明授权
    Compositions for inhibition of necrosis induced by a neurotrophin 有权
    用于抑制由神经营养因子诱导的坏死的组合物

    公开(公告)号：US07608585B2

    公开(公告)日：2009-10-27

    申请号：US10542936

    申请日：2004-01-20

    申请人： Byoung Joo Gwag ,  Sung-Hwa Yoon ,  Sun-Hee Kim ,  Seok-Joon Won

    发明人： Byoung Joo Gwag ,  Sung-Hwa Yoon ,  Sun-Hee Kim ,  Seok-Joon Won

    IPC分类号： A61K38/18 ,  C07C229/68 ,  C07K14/475

    CPC分类号： A61K31/355 ,  A61K31/00 ,  A61K31/60 ,  A61K31/606 ,  A61K38/185 ,  A61K45/06 ,  A61K2300/00

    摘要： Disclosed is a method for inhibition of necrosis induced by neurotrophin, and more specifically a method for inhibition of necrosis by administrating oxidative stress inhibitor and a method for simultaneous inhibition of necrosis and apoptosis by administrating oxidative stress inhibitor and neurotrophin. The oxidative stress inhibitor of the present invention can inhibit nerve cell necrosis induced by neurotrophin. Moreover, it can be used for protecting nerve cell damage connected with alzheimer disease, parkinson's disease, degenerating cerebropathia and promoting regeneration of the nerve cells by administrating oxidative stress inhibitor and neurotrophin.

    摘要翻译： 本发明公开了抑制神经营养因子诱导的坏死的方法，更具体地，是通过施用氧化应激抑制剂来抑制坏死的方法，以及通过施用氧化应激抑制剂和神经营养因子同时抑制坏死和凋亡的方法。 本发明的氧化应激抑制剂可以抑制神经营养蛋白诱导的神经细胞坏死。 此外，它可用于保护与阿尔茨海默病，帕金森病，退行性脑病有关的神经细胞损伤，并通过施用氧化应激抑制剂和神经营养因子促进神经细胞的再生。

    METHOD OF HANDLING AN ERROR ON CS VOICE OVER HSPA
    9.
    发明申请
    METHOD OF HANDLING AN ERROR ON CS VOICE OVER HSPA 有权
    在HSPA上处理CS语音错误的方法

    公开(公告)号：US20090175173A1

    公开(公告)日：2009-07-09

    申请号：US12350030

    申请日：2009-01-07

    申请人： Sun Hee Kim ,  Sung Duck Chun ,  Seung June Yi ,  Young Dae Lee ,  Sung Jun Park

    发明人： Sun Hee Kim ,  Sung Duck Chun ,  Seung June Yi ,  Young Dae Lee ,  Sung Jun Park

    IPC分类号： H04L12/26

    CPC分类号： H04L1/1835 ,  H04L1/165

    摘要： A method of processing data at a specific protocol layer in a wireless communication system is disclosed. The present invention includes the steps of receiving a first data block including sequence information from a lower layer, checking a status of a second data block contained in the first data block, the second data block being an upper layer data block having time information, and if the status of the second data block fails to correspond to a prescribed condition, discarding the first data block.

    摘要翻译： 公开了一种在无线通信系统中的特定协议层处理数据的方法。 本发明包括以下步骤：从下层接收包括序列信息的第一数据块，检查包含在第一数据块中的第二数据块的状态，第二数据块是具有时间信息的上层数据块;以及 如果第二数据块的状态不符合规定条件，则丢弃第一数据块。