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    Electrotransport agent delivery apparatus
    1.
    发明授权
    Electrotransport agent delivery apparatus 有权
    电子输送装置

    公开(公告)号：US07136698B2

    公开(公告)日：2006-11-14

    申请号：US10778748

    申请日：2004-02-12

    申请人： J. Bradley Phipps ,  Gary A. Lattin ,  Ronald P. Haak ,  Felix Theeuwes ,  Suneel K. Gupta

    发明人： J. Bradley Phipps ,  Gary A. Lattin ,  Ronald P. Haak ,  Felix Theeuwes ,  Suneel K. Gupta

    IPC分类号： A61N1/30

    CPC分类号： A61N1/044 ,  A61N1/0448 ,  A61N1/325

    摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein the length of the applied current pulses is at least 5 msec and preferably at least 10 msec. Most preferably, the current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state.

    摘要翻译： 提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。 该装置施加脉冲电输送电流，其中所施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。 最优选地，电流脉冲具有高于临界水平（I C）的幅度，在该临界水平下皮肤被转换成更高的电运送输送效率（E）状态。

    Programmed adjustment of electric current to provide desired electrically assisted transdermal drug delivery rate
    2.
    发明授权
    Programmed adjustment of electric current to provide desired electrically assisted transdermal drug delivery rate 有权
    编程调整电流以提供所需的电辅助透皮药物输送速率

    公开(公告)号：US06219576B1

    公开(公告)日：2001-04-17

    申请号：US09205136

    申请日：1998-12-03

    申请人： Suneel K. Gupta ,  Ronald P. Haak

    发明人： Suneel K. Gupta ,  Ronald P. Haak

    IPC分类号： A61N130

    CPC分类号： A61N1/325

    摘要： The present invention is an apparatus and method that maintains a constant drug delivery rate for an electrotransport delivery system, while the apparent transport efficiency of the system varies, by making adjustments to the output current of the system. More specifically, the constant drug delivery rate is maintained by the regulator of the electrotransport delivery system automatically adjusting the output current to compensate for the varying apparent transport efficiency.

    摘要翻译： 本发明是一种通过调整系统的输出电流来维持电输送系统的恒定药物输送速率的装置和方法，同时系统的视在输送效率变化。 更具体地，恒定的药物输送速率由电运输系统的调节器维持，自动调节输出电流以补偿变化的视在输送效率。

    METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE AND RISPERIDONE
    5.
    发明申请
    METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE AND RISPERIDONE 审中-公开
    用于控制输送PALIPERIDONE和RISPERIDONE的方法和剂型

    公开(公告)号：US20090202631A1

    公开(公告)日：2009-08-13

    申请号：US12428422

    申请日：2009-04-22

    申请人： Nyomi V. Yam ,  Iran Reyes ,  Nipun Davar ,  Atul D. Ayer ,  Julie Lee ,  Sonya Seroff ,  Suneel K. Gupta ,  Gayatri Sathyan

    发明人： Nyomi V. Yam ,  Iran Reyes ,  Nipun Davar ,  Atul D. Ayer ,  Julie Lee ,  Sonya Seroff ,  Suneel K. Gupta ,  Gayatri Sathyan

    IPC分类号： A61K31/519 ,  A61K9/20

    CPC分类号： A61K9/0004 ,  A61K9/0053 ,  A61K9/2086 ,  A61K9/209 ,  A61K31/506 ,  A61K31/519

    摘要： Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.

    摘要翻译： 提供了用于提供帕培酮或利培酮的基本上升释放速率的剂型和方法。 当每天施用一次时，持续释放剂型提供治疗有效的平均稳态血浆普利培酮或利培酮浓度。 这种每天一次的给药方案导致每24小时内出现一次峰值血浆普利培酮或利培酮浓度。 此外，剂量给药后的较晚时间，峰值血浆普利培酮或利培酮浓度发生在比立即释放剂型给药帕立哌酮或利培酮后出现的峰值血浆普利培酮或利培酮浓度更小的程度。

    Electrotransport agent delivery method and apparatus
    8.
    发明授权
    Electrotransport agent delivery method and apparatus 失效
    电子输送剂输送方法和装置

    公开(公告)号：US07212853B1

    公开(公告)日：2007-05-01

    申请号：US08952368

    申请日：1996-06-07

    申请人： J. Bradley Phipps ,  Gary A. Lattin ,  Ronald P. Haak ,  Felix Theeuwes ,  Suneel K. Gupta

    发明人： J. Bradley Phipps ,  Gary A. Lattin ,  Ronald P. Haak ,  Felix Theeuwes ,  Suneel K. Gupta

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/044 ,  A61N1/0448

    摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state. Most preferably the length of the applied current pulses is at least 5 msec and preferably at least 10 msec.

    摘要翻译： 提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。 该装置施加脉冲电输送电流，其中电流脉冲具有高于皮肤转化为更高的电转运递送效率（E）状态的临界水平（I C）以上的幅度。 最优选地，施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。

    Formulations for the administration of fluoxetine
    9.
    发明授权
    Formulations for the administration of fluoxetine 失效
    氟西汀治疗剂型

    公开(公告)号：US06512010B1

    公开(公告)日：2003-01-28

    申请号：US08892118

    申请日：1997-07-14

    申请人： Robert M. Gale ,  Melinda K. Nelson ,  Michel J. N. Cormier ,  Suneel K. Gupta ,  Patricia S. Campbell

    发明人： Robert M. Gale ,  Melinda K. Nelson ,  Michel J. N. Cormier ,  Suneel K. Gupta ,  Patricia S. Campbell

    IPC分类号： A61K3135

    CPC分类号： A61K9/7084 ,  A61K31/135 ,  A61K31/138 ,  A61K31/57 ,  A61K2300/00

    摘要： Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. A preferred embodiment is directed to the transdermal administration of fluoxetine at reduced skin irritation levels wherein fluoxetine, preferably provided as fluoxetine acetate, is coadministered with a corticosteroid such as hydrocortisone. Also disclosed are drug delivery devices containing the fluoxetine or fluoxetine and enhancer composition and methods for the transdermal administration of the fluoxetine and fluoxetine/enhancer composition.

    摘要翻译： 用于通过穿过身体表面或膜透过体外表面或膜施用氟西汀的物质的组成，所述组合物包含单独或与渗透促进剂或混合物组合的待施用氟西汀。 优选的实施方案涉及在减少的皮肤刺激水平下透皮给药氟西汀，其中氟西汀，优选以醋酸氟西汀提供，与皮质类固醇如氢化可的松共同施用。 还公开了含有氟西汀或氟西汀和增强剂组合物的药物递送装置和用于透皮给药氟西汀和氟西汀/增强剂组合物的方法。