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    Cysteine engineered antibodies and conjugates
    1.
    发明授权
    Cysteine engineered antibodies and conjugates 有权
    半胱氨酸改造的抗体和缀合物

    公开(公告)号：US09000130B2

    公开(公告)日：2015-04-07

    申请号：US13154672

    申请日：2011-06-07

    申请人： Sunil Bhakta ,  Jagath R. Junutula

    发明人： Sunil Bhakta ,  Jagath R. Junutula

    IPC分类号： C07K16/00 ,  A61K39/00 ,  A61K47/48 ,  A61K51/10

    CPC分类号： C07K16/00 ,  A61K47/48376 ,  A61K47/48569 ,  A61K47/48715 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6817 ,  A61K47/6829 ,  A61K47/6855 ,  A61K51/1051 ,  C07K16/3092 ,  C07K16/32 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2319/31

    摘要： Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.

    摘要翻译： 在重链或轻链中包含游离半胱氨酸氨基酸的半胱氨酸改造的抗体是通过诱变亲本抗体的核酸序列并用半胱氨酸代替一个或多个氨基酸残基来编码半胱氨酸改造的抗体来制备的; 表达半胱氨酸改造的抗体; 并分离半胱氨酸改造的抗体。 通过PHESELECTOR测定鉴定某些高反应性半胱氨酸工程化抗体。 分离的半胱氨酸改造的抗体可以共价连接到捕获标记，检测标记，药物部分或固体支持物上。

    Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof
    2.
    发明授权
    Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof 失效
    针对单核细胞化学引诱物蛋白-1（MCP-1）的抗体及其用途

    公开(公告)号：US07482434B2

    公开(公告)日：2009-01-27

    申请号：US11641128

    申请日：2006-12-19

    申请人： Jean M. Gudas ,  Mary Haak-Frendscho ,  Orit Foord ,  Meina L. Liang ,  Kiran Ahluwalia ,  Sunil Bhakta

    发明人： Jean M. Gudas ,  Mary Haak-Frendscho ,  Orit Foord ,  Meina L. Liang ,  Kiran Ahluwalia ,  Sunil Bhakta

    IPC分类号： C07K16/00 ,  A61K39/395

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565

    摘要： Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fully human monoclonal antibodies directed to the antigen MCP-1. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

    摘要翻译： 本文描述的本发明的实施方案涉及针对抗原单核细胞化学引诱物蛋白-1（MCP-1）的抗体和这种抗体的用途。 特别地，根据一些实施方案，提供针对抗原MCP-1的完全人单克隆抗体。 编码Nuclotide序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 ，提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof
    4.
    发明授权
    Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof 失效
    针对单核细胞化学引诱物蛋白-1（MCP-1）的抗体及其用途

    公开(公告)号：US07687606B2

    公开(公告)日：2010-03-30

    申请号：US11641633

    申请日：2006-12-19

    申请人： Jean M. Gudas ,  Mary Haak-Frendscho ,  Orit Foord ,  Meina L. Liang ,  Kiran Ahluwalia ,  Sunil Bhakta

    发明人： Jean M. Gudas ,  Mary Haak-Frendscho ,  Orit Foord ,  Meina L. Liang ,  Kiran Ahluwalia ,  Sunil Bhakta

    IPC分类号： C07K14/00 ,  A61K39/395 ,  C12P21/00

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565

    摘要： Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fully human monoclonal antibodies directed to the antigen MCP-1. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

    摘要翻译： 本文描述的本发明的实施方案涉及针对抗原单核细胞化学引诱物蛋白-1（MCP-1）的抗体和这种抗体的用途。 特别地，根据一些实施方案，提供针对抗原MCP-1的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 ，提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof
    8.
    发明申请
    Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof 失效
    针对单核细胞化学引诱物蛋白-1（MCP-1）的抗体及其用途

    公开(公告)号：US20070116708A1

    公开(公告)日：2007-05-24

    申请号：US11641633

    申请日：2006-12-19

    申请人： Jean Gudas ,  Mary Haak-Frendscho ,  Orit Foord ,  Meina Liang ,  Kiran Ahluwalia ,  Sunil Bhakta

    发明人： Jean Gudas ,  Mary Haak-Frendscho ,  Orit Foord ,  Meina Liang ,  Kiran Ahluwalia ,  Sunil Bhakta

    IPC分类号： A61K39/395 ,  C07K16/24

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565

    摘要： Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fully human monoclonal antibodies directed to the antigen MCP-1. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

    摘要翻译： 本文描述的本发明的实施方案涉及针对抗原单核细胞化学引诱物蛋白-1（MCP-1）的抗体和这种抗体的用途。 特别地，根据一些实施方案，提供针对抗原MCP-1的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 ，提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。