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    APPARATUS AND METHODS FOR SEALING A PUNCTURE IN TISSUE
    3.
    发明申请
    APPARATUS AND METHODS FOR SEALING A PUNCTURE IN TISSUE 有权
    用于密封组织中的针刺的装置和方法

    公开(公告)号：US20110301640A1

    公开(公告)日：2011-12-08

    申请号：US13210363

    申请日：2011-08-15

    申请人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Juan Domingo

    发明人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Juan Domingo

    IPC分类号： A61B17/03

    CPC分类号： A61B17/0057 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61M25/10 ,  A61M25/10181 ,  A61M25/10182 ,  A61M2025/1068

    摘要： An occlusion device for sealing a puncture through tissue includes a tubular wire member having a proximal end, a distal end sized for insertion into the puncture, a lumen extending between the proximal and distal ends, a port adjacent the proximal end communicating with the lumen, and a balloon on the distal end. A source of fluid is connectable to the wire member for delivering fluid via the port into the lumen for expanding the balloon. A piston is movable axially within the wire member to allow fluid to be delivered into the lumen, to isolate the lumen, and to deliver fluid within the lumen into the balloon to expand the balloon.

    摘要翻译： 用于密封通过组织的穿刺的闭塞装置包括管状线构件，其具有近端，尺寸适于插入穿刺的远端，在近端和远端之间延伸的腔，邻近与内腔连通的近端的端口， 和远端的气球。 流体源可连接到线构件，用于将流体经由端口输送到用于扩张气囊的内腔中。 活塞可以在线构件内轴向移动以允许流体被输送到内腔中，以隔离内腔，并且将内腔内的流体输送到气囊中以使气囊膨胀。

    Methods and apparatus for treating vascular occlusions
    5.
    发明授权
    Methods and apparatus for treating vascular occlusions 有权
    治疗血管闭塞的方法和装置

    公开(公告)号：US06599304B1

    公开(公告)日：2003-07-29

    申请号：US09443924

    申请日：1999-11-19

    申请人： Matthew R. Selmon ,  Charles F. Milo ,  Robert L. Wynne ,  Suresh S. Pai ,  Kent D. Dell ,  Charles Gresl

    发明人： Matthew R. Selmon ,  Charles F. Milo ,  Robert L. Wynne ,  Suresh S. Pai ,  Kent D. Dell ,  Charles Gresl

    IPC分类号： A61M2900

    CPC分类号： A61M29/02 ,  A61B17/22 ,  A61B17/22031 ,  A61B2017/00845 ,  A61B2017/22052 ,  A61B2017/22069 ,  A61B2017/22094 ,  A61B2017/2933 ,  A61B2017/2937 ,  A61B2017/320044 ,  A61B2017/320741

    摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.

    摘要翻译： 一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。 可以提供致动组件用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。 组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。 还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。 定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

    Apparatus and methods for sealing a vascular puncture
    6.
    发明授权
    Apparatus and methods for sealing a vascular puncture 有权
    用于密封血管穿刺的装置和方法

    公开(公告)号：US08945178B2

    公开(公告)日：2015-02-03

    申请号：US13610849

    申请日：2012-09-11

    申请人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    发明人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    IPC分类号： A61B17/03 ,  A61B17/00

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00672

    摘要： Apparatus for sealing a puncture through tissue to a blood vessel includes a cartridge including a proximal end, a distal end sized for insertion into a puncture, and a lumen extending therebetween. A bioabsorbable plug is disposed within the lumen adjacent the distal end, and an anchoring element is disposed within the lumen proximal to the plug. A pusher member is disposed within the lumen for deploying the plug and anchoring element out the distal end of the cartridge. The plug may be formed from lyophilized hydrogel and the anchoring element may be formed from air-dried hydrogel, the anchoring element hydrating slower than the plug when exposed to an aqueous environment. During use, the plug and anchoring element are delivered into the puncture, the plug is cinched against the vessel wall. Protrusions on the anchoring element engage tissue surrounding the puncture to prevent proximal movement of the plug.

    摘要翻译： 用于将穿过组织的穿刺密封到血管的装置包括：盒，其包括近端，尺寸适于插入穿刺的远端以及在其间延伸的内腔。 生物可吸收塞子设置在邻近远端的内腔内，并且锚定元件设置在靠近塞子的内腔内。 推动器构件设置在内腔内，用于将插塞和锚固元件从盒的远端伸出。 塞子可以由冻干的水凝胶形成，并且锚定元件可以由空气干燥的水凝胶形成，当暴露于水性环境时，锚定元件比塞子保持缓慢。 在使用过程中，插头和锚定元件被输送到穿刺部分中，塞子紧贴在血管壁上。 锚固元件上的突起接合穿刺周围的组织，以防止插塞的近端移动。

    Superabsorbent, freeze dried hydrogels for medical applications
    7.
    发明授权
    Superabsorbent, freeze dried hydrogels for medical applications 有权
    超吸收剂，用于医疗应用的冷冻干燥水凝胶

    公开(公告)号：US08795709B2

    公开(公告)日：2014-08-05

    申请号：US11465791

    申请日：2006-08-18

    申请人： Amarpreet S. Sawhney ,  Steven L. Bennett ,  Suresh S. Pai ,  Scott R. Sershen ,  Fred H. Co

    发明人： Amarpreet S. Sawhney ,  Steven L. Bennett ,  Suresh S. Pai ,  Scott R. Sershen ,  Fred H. Co

    IPC分类号： A61F2/00

    CPC分类号： A61L24/0031 ,  A61B2017/0065 ,  A61L24/046 ,  A61L24/10 ,  C08L71/02

    摘要： Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.

    摘要翻译： 提供了用于制备冻干的水凝胶和其结构的方法，其可以被引入患者体内用于医疗应用。 组合前体组分以引发交联。 将组合的前体组分置于冷藏的托盘中，并在放置在托盘上之前和/或之后使其交联至所需水平的完全交联。 将部分交联的水凝胶冷冻并冷冻干燥。 冷冻干燥后，将水凝胶调节至基本上完全交联，并形成一种或多种结构，例如塞子，止血剂或其他医疗装置。 例如，水凝胶可以被切割，机加工，滚压，折叠，压缩和/或加工成可以被加载到可被引入到体内的输送装置中以将结构植入或以其他方式将结构输送到体内，例如 密封穿刺或穿过组织的其他通道。

    Occlusion member and tensioner apparatus and methods of their use for sealing a vascular puncture
    8.
    发明授权
    Occlusion member and tensioner apparatus and methods of their use for sealing a vascular puncture 有权
    闭塞成员和张紧器设备及其用于密封血管穿刺的方法

    公开(公告)号：US07985240B2

    公开(公告)日：2011-07-26

    申请号：US11929762

    申请日：2007-10-30

    申请人： Celso J. Bagaoisan ,  Juan Domingo ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    发明人： Celso J. Bagaoisan ,  Juan Domingo ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00557 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61M25/10182 ,  A61M25/10187 ,  A61M2025/0681

    摘要： Apparatus for sealing a puncture includes an elongate occlusion member having a balloon attached to distal ends of telescoping inner and outer members. A housing on the proximal end of the outer member includes a piston coupled to the inner member and slidable within a chamber communicating with a fluid reservoir. A switch on the housing is actuated to direct fluid from the reservoir through the outer member into the balloon to expand the balloon and into the chamber to move the piston and pull the inner member, shortening the balloon as it expands. During use, the distal end of the occlusion member is introduced into a puncture communicating with a vessel until the collapsed balloon is disposed within the vessel. The balloon is expanded, and a tensioner is connected to the housing to apply a proximal force holding the balloon against the vessel wall to seal the puncture.

    摘要翻译： 用于密封穿刺的装置包括具有附接到伸缩的内部和外部构件的远端的气囊的细长闭塞构件。 外部构件的近端上的壳体包括联接到内部构件并可在与流体储存器连通的腔室内滑动的活塞。 启动壳体上的开关以将流体从储存器引导通过外部构件进入气囊，以使气囊膨胀并进入腔室中，以移动活塞并拉动内部构件，从而在气囊膨胀时缩短气囊。 在使用期间，将阻塞构件的远端引入到与血管连通的穿刺件中，直到将收缩的气囊设置在血管内。 气囊膨胀，并且张紧器连接到壳体以施加将气囊保持抵靠血管壁的近侧力以密封穿刺。