公开(公告)号：US08916576B2

公开(公告)日：2014-12-23

申请号：US13715644

申请日：2012-12-14

Applicant: Surface Logix, Inc.

Inventor： Alessandra Bartolozzi ,  Stewart Campbell ,  Hope Foudoulakis ,  Brian Kirk ,  Siya Ram ,  Paul Sweetnam ,  Hemalatha Seshadri

IPC: A01N43/54 ,  A61K31/517 ,  C07D403/14 ,  C07D413/14 ,  C07D405/14 ,  C07D401/14 ,  C07D403/12 ,  B82Y30/00

CPC classification number: C07D413/14 ,  B82Y30/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.

Abstract translation: 本发明涉及ROCK1和ROCK2的抑制剂以及调节这些化合物的药代动力学和/或药效学性质的方法。 还提供抑制可用于治疗疾病的ROCK1和/或ROCK2的方法。

公开(公告)号：US20040266307A1

公开(公告)日：2004-12-30

申请号：US10714190

申请日：2003-11-14

Applicant: Surface Logix, Inc.

Inventor： Christopher H. McCoy ,  John T. Chen ,  David R. Beaulieu

IPC: H01J009/00 ,  H01J009/24

CPC classification number: B82Y30/00 ,  G02F1/133512 ,  G02F1/133516 ,  G02F1/13439 ,  G02F1/1362

Abstract: A system and method are described for self-aligning electrodes for color filters of passive matrix displays.

Abstract translation: 描述了用于无源矩阵显示器的彩色滤光片的自对准电极的系统和方法。

公开(公告)号：US20040261981A1

公开(公告)日：2004-12-30

申请号：US10713619

申请日：2003-11-13

Applicant: Surface Logix, Inc.

Inventor： Christopher H. McCoy ,  John T. Chen ,  David R. Beaulieu

IPC: B32B003/10

CPC classification number: H01L23/3737 ,  H01L21/4871 ,  H01L23/3677 ,  H01L23/3733 ,  H01L2924/0002 ,  Y10T428/24273 ,  H01L2924/00

Abstract: A thermal management material that may be used is thermal interface material is described. An apparatus and methods of the making the thermal management material are also described, which includes a roll-to-roll apparatus for making the thermal management material.

Abstract translation: 可以使用的热管理材料是热界面材料。 还描述了制造热管理材料的装置和方法，其包括用于制造热管理材料的卷对卷装置。

公开(公告)号：US20180072710A1

公开(公告)日：2018-03-15

申请号：US15495019

申请日：2017-04-24

Applicant: SURFACE LOGIX, INC.

Inventor： Alessandra Bartolozzi ,  Stewart Campbell ,  Hope Foudoulakis ,  Brian Kirk ,  Siya Ram ,  Paul Sweetnam ,  Hemalatha Seshardri

IPC: C07D413/14 ,  C07D405/14 ,  B82Y30/00 ,  C07D403/12 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D413/14 ,  B82Y30/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.

公开(公告)号：US20150344464A1

公开(公告)日：2015-12-03

申请号：US14581746

申请日：2014-12-23

Applicant: SURFACE LOGIX, INC.

Inventor： ALESSANDRA BARTOLOZZI ,  STEWART CAMPBELL ,  HOPE FOUDOULAKIS ,  BRIAN KIRK ,  SIYA RAM ,  PAUL SWEETNAM

IPC: C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  C07D403/12

CPC classification number: C07D413/14 ,  B82Y30/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.

Abstract translation: 本发明涉及ROCK1和ROCK2的抑制剂以及调节这些化合物的药代动力学和/或药效学性质的方法。 还提供抑制可用于治疗疾病的ROCK1和/或ROCK2的方法。

公开(公告)号：US20130096114A1

公开(公告)日：2013-04-18

申请号：US13708420

申请日：2012-12-07

Applicant: SURFACE LOGIX, INC.

Inventor： Stewart Campbell ,  David Duffy ,  Michael Grogan ,  Steven Kates ,  Emanuele Ostuni ,  Olivier Schueller ,  Paul Sweetnam

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.

Abstract translation: 提供具有改善的非特异性结合特征和药代动力学性质的式A化合物：或其药学上可接受的盐，立体异构体或其水合物。

公开(公告)号：US20190177311A1

公开(公告)日：2019-06-13

申请号：US16040245

申请日：2018-07-19

Applicant: SURFACE LOGIX, INC.

Inventor： Alessandra Bartolozzi ,  Stewart Campbell ,  Hope Foudoulakis ,  Brian Kirk ,  Siya Ram ,  Paul Sweetnam ,  Hemalatha Seshardri

IPC: C07D413/14 ,  C07D405/14 ,  C07D403/14 ,  B82Y30/00 ,  C07D401/14 ,  C07D403/12

Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.

公开(公告)号：US09440961B2

公开(公告)日：2016-09-13

申请号：US14581746

申请日：2014-12-23

Applicant: SURFACE LOGIX, INC.

Inventor： Alessandra Bartolozzi ,  Stewart Campbell ,  Hope Foudoulakis ,  Brian Kirk ,  Siya Ram ,  Paul Sweetnam ,  Hemalatha Seshadri

IPC: C07D413/14 ,  B82Y30/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

CPC classification number: C07D413/14 ,  B82Y30/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.

Abstract translation: 本发明涉及ROCK1和ROCK2的抑制剂以及调节这些化合物的药代动力学和/或药效学性质的方法。 还提供了抑制可用于治疗疾病的ROCK1和/或ROCK2的方法。

公开(公告)号：US08853394B2

公开(公告)日：2014-10-07

申请号：US13708420

申请日：2012-12-07

Applicant: Surface Logix, Inc.

Inventor： Stewart Campbell ,  David Duffy ,  Michael Grogan ,  Steven Kates ,  Emanuele Ostuni ,  Olivier Schueller ,  Paul Sweetnam

IPC: C07D487/04 ,  A61K31/53 ,  A61P9/02 ,  A61P15/10

CPC classification number: C07D487/04

Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.

Abstract translation: 提供具有改善的非特异性结合特征和药代动力学性质的式A化合物：或其药学上可接受的盐，立体异构体或其水合物。

公开(公告)号：US20130131047A1

公开(公告)日：2013-05-23

申请号：US13715644

申请日：2012-12-14

Applicant: SURFACE LOGIX, INC.

Inventor： ALESSANDRA BARTOLOZZI ,  STEWART CAMPBELL ,  HOPE FOUDOULAKIS ,  BRIAN KIRK ,  SIYA RAM ,  PAUL SWEETNAM

IPC: C07D413/14 ,  C07D405/14 ,  C07D403/12 ,  C07D403/14 ,  C07D401/14

CPC classification number: C07D413/14 ,  B82Y30/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.