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    S1P Receptor Modulating Compounds and Use Thereof
    1.
    发明申请
    S1P Receptor Modulating Compounds and Use Thereof 审中-公开
    S1P受体调节化合物及其用途

    公开(公告)号：US20120088749A1

    公开(公告)日：2012-04-12

    申请号：US13327951

    申请日：2011-12-16

    申请人： Susana C. Neira ,  Xiang Yu ,  Roland Burli ,  Victor Cee ,  Brian Lanman

    发明人： Susana C. Neira ,  Xiang Yu ,  Roland Burli ,  Victor Cee ,  Brian Lanman

    IPC分类号： A61K31/397 ,  C07D401/10 ,  A61K31/4427 ,  A61P37/06 ,  A61P29/00 ,  A61P35/02 ,  A61P3/10 ,  A61P25/00 ,  A61P17/06 ,  A61P1/04 ,  A61P1/00 ,  C07D205/04 ,  A61P19/04

    CPC分类号： C07D205/04 ,  C07D401/10

    摘要： The present invention relates to amides that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

    摘要翻译： 本发明涉及具有作为S1P受体调节剂的活性的酰胺和这些化合物用于治疗与不适当的S1P受体活性相关的疾病的用途。 这些化合物可用作免疫调节剂，例如用于治疗或预防诸如自身免疫性疾病和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病如克罗恩病和溃疡性结肠炎，I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿 关节炎，非肾小球性肾病，肝炎，白塞病，肾小球性肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和韦格纳肉芽肿; 并处理其他条件。

    S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF
    5.
    发明申请
    S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF 失效
    S1P受体调节化合物及其用途

    公开(公告)号：US20090082331A1

    公开(公告)日：2009-03-26

    申请号：US12234514

    申请日：2008-09-19

    申请人： Susana C. Neira ,  Xiang Yu

    发明人： Susana C. Neira ,  Xiang Yu

    IPC分类号： A61K31/397 ,  C07D205/04 ,  A61P37/06 ,  A61P19/02 ,  A61P3/10 ,  A61P1/00 ,  A61P35/02

    CPC分类号： C07D205/04 ,  C07D401/10

    摘要： The present invention relates to amides that have activity as SIP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

    摘要翻译： 本发明涉及具有作为SIP受体调节剂的活性的酰胺和这些化合物用于治疗与不适当的S1P受体活性相关的疾病的用途。 这些化合物可用作免疫调节剂，例如用于治疗或预防诸如自身免疫性疾病和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病如克罗恩病和溃疡性结肠炎，I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿 关节炎，非肾小球性肾病，肝炎，白塞病，肾小球性肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和韦格纳肉芽肿; 并处理其他条件。