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公开(公告)号：US20240299535A1
公开(公告)日：2024-09-12
申请号：US18579096
申请日：2022-07-13
发明人： Paul L. DeAngelis , Dixy E. Green , Stefan Wilhelm , Wen Yang
IPC分类号： A61K39/385 , A61K39/00 , A61K47/61 , A61K47/69
CPC分类号： A61K39/385 , A61K47/61 , A61K47/6929 , A61K2039/53 , A61K2039/6087
摘要： Compositions containing compositions of heparosan polymers linked to a particle, such as a metallic or polymeric or lipid-containing nanoparticle are described, for use in cell delivery applications.
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公开(公告)号：US20240263066A1
公开(公告)日：2024-08-08
申请号：US18407624
申请日：2024-01-09
发明人： Saeed SALEHI , Reza FOUDAZI
CPC分类号： C09K8/845 , B82Y30/00 , E21B49/008
摘要： A method of formulating a nanofluid for use in a geologic formation for determining an average pore size of the geologic formation by selecting a desired flow rate of the nanofluid under a predetermined applied pressure, using the calculated average pore size and desired flow rate to estimate a desired average viscosity of the nanofluid, and producing the nanofluid having the desired average viscosity by combining a quantity of nanoparticles with an aqueous medium. A nanofluid made by said process. A method of treating a geologic formation, such as a geothermal formation, by injecting said nanofluid into the geologic formation.
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公开(公告)号：US12004493B2
公开(公告)日：2024-06-11
申请号：US16429978
申请日：2019-06-03
发明人： Hiroshi Yamada , Chinthalapally Rao
IPC分类号： A01K67/027 , A01K67/0276 , G01N33/50
CPC分类号： A01K67/0276 , G01N33/5088 , A01K2217/20 , A01K2227/105 , A01K2267/0312
摘要： An animal model (e.g., mouse) and method of use, and cell culture assay method, for characterizing or screening a test compound for its effect on late onset Alzheimer's disease (LOAD). The test compound may be used as a therapeutic agent for treatment of Alzheimer's disease (AD). The AD animal model may be haploinsufficient for Shugoshin 1 (Sgo1) gene, or may comprise a genetic modification enabling modulation of Sgo1 expression in the brain of the animal when exposed to an Sgo1 expression-modulating compound, such as tamoxifen. After the test compound is administered to the animal model, the presence or amount of an AD biomarker is assessed or measured.
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公开(公告)号：US11905671B2
公开(公告)日：2024-02-20
申请号：US17581304
申请日：2022-01-21
发明人： Blake A. Herren , Yingtao Liu , M. Cengiz Altan , Mrinal C. Saha
CPC分类号： E02B15/045 , E02B15/048 , E02B15/101
摘要： A sorbent-based oil skimmer is configured to collect oil from an oil layer and passively deposit the oil in an encasing, where the oil can be continuously or periodically removed. The oil skimmer includes an encasing and a sponge that is partially enclosed within the encasing. The sponge has a top sheet in contact with the oil layer and a shell connected to the top sheet, where the shell extends into the encasing. Oil collected by the top sheet is conveyed through the shell, where it is deposited into the encasing under the force of gravity. In some applications, the sponge is manufactured from a silicone-based polymer that has been impregnated with carbonaceous material. The skimmer may optionally include counterweights, ballast tanks, buoyancy adjustment systems and propulsion modules.
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5.发明公开公开(公告)号：US20230361481A1
公开(公告)日：2023-11-09
申请号：US18245484
申请日：2021-10-11
CPC分类号： H01Q21/005 , H01Q21/24 , H01Q3/36
摘要： An X-band dual-polarized slotted waveguide antenna (SWGA) array unit cell comprises a partial H-plane waveguide with a metal vane; and a conventional waveguide in a side-by-side arrangement with the partial H-plane waveguide. A spacing between elements of the X-band dual-polarized SWGA array unit cell in an azimuth plane is in a range of about 0.6 λo to about 0.5 λo. The X-band dual-polarized SWGA array unit cell has a one-dimensional (1D) electronic-scanning range of at least 84° (±42°) in the azimuth plane perpendicular to a waveguide axis. The X-band dual-polarized SWGA array unit cell has a cross-polarization isolation of about −60 decibels (dB) or less.
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6.发明公开公开(公告)号：US20230293185A1
公开(公告)日：2023-09-21
申请号：US18318916
申请日：2023-05-17
发明人： Yingtao LIU , Chung-Hao Lee , Bradley Bohnstedt , Robert Kunkel
CPC分类号： A61B17/12195 , A61B17/12113 , A61L31/024 , A61L31/14 , A61L31/146 , A61B17/12145 , A61B2017/00871
摘要： A novel shape memory polymer (SMP)-based device for surgical treatment of an intracorporeal defect (e.g., a void or anomaly) such as an intracranial aneurysm or fistula. In at least one non-limiting embodiment, the SMP device is a 3D-printed SMP material sized to specifically fit and thus occlude an intracranial aneurysm (ICA). The SMP device may be delivered to the intracorporeal defect via a catheter having a heating mechanism wherein the SMP device is raised above its glass transition temperature as it is deployed, causing the SMP device to return to its permanent shape after it is deployed into the intracorporeal defect. SMP device delivery systems that include the SMP devices, as well as methods of making and using the devices and systems, are also disclosed.
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公开(公告)号：US11744565B2
公开(公告)日：2023-09-05
申请号：US16754656
申请日：2018-09-28
发明人： Jason Lees
IPC分类号： A61B17/00 , A61B17/3203 , A61B17/32
CPC分类号： A61B17/00234 , A61B17/3203 , A61B2017/00561 , A61B2017/320064 , A61B2217/005
摘要： A surgical evacuation apparatus and method for evacuating a biological material from a body cavity. The surgical evacuation apparatus has a shaft and a scoop extending from a distal end of the shaft. The shaft has a supply inlet for connecting to a pressurized fluid source and an outlet for connecting to a vacuum source. An evacuation channel extends from the scoop to the outlet. A fluid supply channel extends in the shaft from the supply inlet towards the distal end and intersects the evacuation channel proximate the scoop. Material desired to be removed from the body cavity is collected in the scoop by a user. The biological material collected in the scoop is broken up by a fluid stream from the supply channel and is drawn into the evacuation channel by a vacuum applied by the vacuum source and is removed from the body cavity.
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公开(公告)号：US20230268721A1
公开(公告)日：2023-08-24
申请号：US18168337
申请日：2023-02-13
发明人： Rui Q. Yang , John F. Klem
CPC分类号： H01S5/3402 , H01S5/34306 , H01S5/3422
摘要： An ICL comprises: a plurality of IC stages, wherein each of the IC stages comprises: a hole injector; an electron injector; an active region coupled to the hole injector and the electron injector and comprising a first layer, wherein the first layer comprises a first material, and wherein the first material comprises InAsP or AlInAsP; a conduction band running through the hole injector, the electron injector, and the active region; and a valence band running through the hole injector, the electron injector, and the active region.
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公开(公告)号：US20230152313A1
公开(公告)日：2023-05-18
申请号：US17797619
申请日：2021-02-04
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N2800/52 , G01N2800/101
摘要： The present invention includes a method and kit of determining that a patient negative for anti- Ro autoantibodies has Sjögren’s syndrome (SS) without performing a lip biopsy comprising: obtaining a liquid biological sample from the patient suspected of having SS; determining that the patient is negative for anti-Ro autoantibodies; and detecting autoantibodies to 1, 2, 3, 4, 5, 6, 7, 8, or 9 proteins selected from: CCDC155, DDB1, MUM1L1, NFU1, RPS29, SOX5, TCP10, ZNF655, or RPAP3, which indicate(s) that the patient has SS. Also, a lack of certain autoantibodies such as KCNAB1, KCNAB2, or as listed in Table 1, Table 2, or Table 3, and FIGS. 11 or 16 in Ro neg cases may be used to detect SS.
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公开(公告)号：US20230087030A1
公开(公告)日：2023-03-23
申请号：US17796125
申请日：2021-01-22
发明人： BINBIN WENG
IPC分类号： H01L31/032 , H01L31/0304 , H01L31/028
摘要： A method of manufacturing a lead salt thin film on a substrate by seeding a substrate with a lead salt solution (e.g., PbSe, PbS, or PbTe) to form a seeded substrate comprising lead salt seed crystals, and growing the lead salt thin film upon the substrate by exposing the seeded substrate to a chemical bath comprising the lead salt solution at a predetermined growth temperature. A lead salt thin film manufactured by the process. A photonic crystal microchip comprising the lead salt thin film. A gas sensing device comprising a diode laser, a mid-infrared photodetector, and the photonic crystal microchip. A method of detecting a hydrocarbon gas, comprising exposing a gas sample to the gas sensing device, and determining the content of hydrocarbon gases in the gas sample.
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