-
公开(公告)号：US06518429B2
公开(公告)日：2003-02-11
申请号：US09813437
申请日：2001-03-20
申请人： Hyun Il Lee , Jong Sung Koh , Jin Ho Lee , Won Hee Jung , You Seung Shin , Hyun Ho Chung , Jong Hyun Kim , Seong Gu Ro , Tae Saeng Choi , Shin Wu Jeong , Tae Hwan Kwak , In Ae Ahn , Hyun Sung Kim , Sun Hwa Lee , Kwi Hwa Kim , Jung Kwon Yoo
发明人： Hyun Il Lee , Jong Sung Koh , Jin Ho Lee , Won Hee Jung , You Seung Shin , Hyun Ho Chung , Jong Hyun Kim , Seong Gu Ro , Tae Saeng Choi , Shin Wu Jeong , Tae Hwan Kwak , In Ae Ahn , Hyun Sung Kim , Sun Hwa Lee , Kwi Hwa Kim , Jung Kwon Yoo
IPC分类号： C07D45302
CPC分类号： C07D401/14 , C07D403/06 , C07D405/14 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention relates to novel imidazole derivatives which show an inhibitory activity against farnesyl transferase, pharmaceutically acceptable salts or isomers thereof and pharmaceutical compositions comprising such imidazole derivatives. More particularly, the present invention relates to intermediate compounds which are used in the preparation of the imidazole derivatives of the invention. Related processes also are disclosed.
-
2.发明授权Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof 失效具有法呢基转移酶抑制活性的咪唑衍生物及其制备方法公开(公告)号：US06472526B1
公开(公告)日：2002-10-29
申请号：US10005262
申请日：2001-12-03
申请人： Hyun Il Lee , Jong Sung Koh , Jin Ho Lee , Won Hee Jung , You Seung Shin , Hyun Ho Chung , Jong Hyun Kim , Seong Gu Ro , Tae Saeng Choi , Shin Wu Jeong , Tae Hwan Kwak , In Ae Ahn , Hyun Sung Kim , Sun Hwa Lee , Kwi Hwa Kim , Jung Kwon Yoo
发明人： Hyun Il Lee , Jong Sung Koh , Jin Ho Lee , Won Hee Jung , You Seung Shin , Hyun Ho Chung , Jong Hyun Kim , Seong Gu Ro , Tae Saeng Choi , Shin Wu Jeong , Tae Hwan Kwak , In Ae Ahn , Hyun Sung Kim , Sun Hwa Lee , Kwi Hwa Kim , Jung Kwon Yoo
IPC分类号： C07D40306
CPC分类号： C07D401/14 , C07D403/06 , C07D405/14 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1): and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.
摘要翻译： 本发明涉及式（1）所示的新型咪唑衍生物，其表现出对法呢基转移酶的抑制活性或其药学上可接受的盐或异构体，其中A，n1和Y在本说明书中定义; 涉及制备式（1）化合物的方法; 用于制备式（1）化合物的中间体：和包含式（1）化合物作为活性成分的药物组合物。
-
3.发明申请COMPOSITION FOR TREATING OR PREVENTING HEARING LOSS COMPRISING NAPHTHOQUINONE-BASED COMPOUNDS 审中-公开用于处理或防止包含基于萘基的化合物的听力损失的组合物公开(公告)号：US20120289577A1
公开(公告)日：2012-11-15
申请号：US13519512
申请日：2010-12-27
申请人： Tae Hwan Kwak , Myung-Gyu Park , Hong-Seob So , Raekil Park , Hyung-Jin Kim
发明人： Tae Hwan Kwak , Myung-Gyu Park , Hong-Seob So , Raekil Park , Hyung-Jin Kim
IPC分类号： A61K31/352 , C07D307/92 , A61K31/343 , C07D311/78 , C07D311/96 , A61P27/16 , A61K31/382 , C07D333/74 , A61K31/381 , C07D327/06 , A61K31/39 , C07D307/77 , C07D311/92 , C07D335/08
CPC分类号： A61K31/352 , A61K31/343 , A61K31/381 , A61K31/382 , A61K31/39
摘要： The present invention relates to a composition for treating or preventing hearing loss comprising naphthoquinone-based compounds.
摘要翻译： 本发明涉及包含萘醌类化合物的治疗或预防听力损失的组合物。
-
公开(公告)号：US08002015B2
公开(公告)日：2011-08-23
申请号：US12290265
申请日：2008-10-29
申请人： Tae-Hwan Kwak
发明人： Tae-Hwan Kwak
摘要： A cooling system for a low pressure casting device, which includes an upper mold provided with a core portion of a spark plug and an upper die, a lower mold provided with a mold portion of a combustion chamber and a lower die, and side molds, may include i) a coolant supply unit connected respectively to the core portion of the spark plug, the upper die, the mold portion of the combustion chamber, and the lower die through coolant supply lines, ii) a cooling air supply unit connected respectively to the side molds and the mold portion of the combustion chamber through air supply lines, and iii) a vacuum intake unit connected respectively to the core portion of the spark plug, the upper die, the mold portion of the combustion chamber, and the lower die through vacuum intake lines.
摘要翻译： 一种用于低压铸造装置的冷却系统，其包括设置有火花塞的芯部和上模的上模，设置有燃烧室的模具部分的下模和下模，以及侧模， 可以包括：i）冷却剂供应单元，其分别连接到火花塞的中心部分，上模具，燃烧室的模具部分和通过冷却剂供应管线的下模具; ii）冷却空气供应单元，分别连接到 燃烧室的侧模和模具部分，以及iii）分别连接到火花塞的中心部分，上模具，燃烧室的模具部分和下模具的真空进气单元 通过真空吸气管。
-
5.发明授权Active fraction having anti-cancer and anti-metastasis isolated from leaves and stems of ginseng 有权从人参叶和茎分离的具有抗癌和抗转移的活性成分公开(公告)号：US07901716B2
公开(公告)日：2011-03-08
申请号：US10515960
申请日：2003-05-28
申请人： Tae Hwan Kwak , Myoung Sook Shin , Ji Yeon Kim , Jong-Kook Park
发明人： Tae Hwan Kwak , Myoung Sook Shin , Ji Yeon Kim , Jong-Kook Park
IPC分类号： A61K36/00 , A61K36/254 , A61K9/00 , A61K47/00
CPC分类号： A61K36/258 , A23L33/105 , A61K31/191 , A61K31/225 , A61K31/7004 , A61K31/7012 , A61K31/702 , A61K2300/00
摘要： Provided is a composition that contains, as an active ingredient, an extract or polysaccharides separated from the leaves and/or stems of plants belonging to Panax genus, for an anticancer drug or its adjuvant, having an effect on the activity of hematopoiesis enhancement, cancer metastasis inhibition, bone marrow defense, etc. . . . , and a process for preparation of the extract from the leaves and/or stems of plants belonging to Panax genus.
摘要翻译： 提供一种组合物，其含有作为活性成分的从属于Panax属的植物的叶和/或茎分离的抗癌药或其佐剂的提取物或多糖，其对造血功能增强的活性有影响，癌症 转移抑制，骨髓防御等。 。 。 以及从属于Panax属植物的叶和/或茎的提取物的制备方法。
-
6.发明授权Farnesyl transferase inhibitors having a piperidine structure and process for preparation thereof 失效具有哌啶结构的法呢基转移酶抑制剂及其制备方法公开(公告)号：US06436960B1
公开(公告)日：2002-08-20
申请号：US09601426
申请日：2000-08-01
申请人： You Seung Shin , Jong Sung Koh , Hyun Il Lee , Jin Ho Lee , Jong Hyun Kim , Hyun Ho Chung , Kwi Hwa Kim , Tae Hwan Kwak , Seong Gu Ro , In Ae Ahn , Tae Saeng Choi , Young Hoon Oh , Chung Mi Kim , Sun Hwa Lee , Hyun Sung Kim
发明人： You Seung Shin , Jong Sung Koh , Hyun Il Lee , Jin Ho Lee , Jong Hyun Kim , Hyun Ho Chung , Kwi Hwa Kim , Tae Hwan Kwak , Seong Gu Ro , In Ae Ahn , Tae Saeng Choi , Young Hoon Oh , Chung Mi Kim , Sun Hwa Lee , Hyun Sung Kim
IPC分类号： A61K31454
CPC分类号： C07D401/14 , C07D417/14
摘要： The present invention relates to a novel piperidine derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts thereof, in which A, E and G are defined in the specification; to a process for preparation of the compound of formula (1); to an intermediate which is used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.
摘要翻译： 本发明涉及式（1）所示的新型哌啶衍生物，其表现出对法呢基转移酶的抑制活性或其药学上可接受的盐，其中A，E和G在本说明书中定义; 涉及制备式（1）化合物的方法; 涉及用于制备式（1）化合物的中间体; 以及包含式（1）化合物作为活性成分的药物组合物。
-
公开(公告)号：US20090250186A1
公开(公告)日：2009-10-08
申请号：US12290265
申请日：2008-10-29
申请人： Tae-Hwan Kwak
发明人： Tae-Hwan Kwak
摘要： A cooling system for a low pressure casting device, which includes an upper mold provided with a core portion of a spark plug and an upper die, a lower mold provided with a mold portion of a combustion chamber and a lower die, and side molds, may include i) a coolant supply unit connected respectively to the core portion of the spark plug, the upper die, the mold portion of the combustion chamber, and the lower die through coolant supply lines, ii) a cooling air supply unit connected respectively to the side molds and the mold portion of the combustion chamber through air supply lines, and iii) a vacuum intake unit connected respectively to the core portion of the spark plug, the upper die, the mold portion of the combustion chamber, and the lower die through vacuum intake lines.
摘要翻译： 一种用于低压铸造装置的冷却系统，其包括设置有火花塞的芯部和上模的上模，设置有燃烧室的模具部分的下模和下模，以及侧模， 可以包括：i）冷却剂供应单元，其分别连接到火花塞的中心部分，上模具，燃烧室的模具部分和通过冷却剂供应管线的下模具，ii）冷却空气供应单元，分别连接到 燃烧室的侧模和模具部分，以及iii）分别连接到火花塞的中心部分，上模具，燃烧室的模具部分和下模具的真空进气单元 通过真空吸气管。
-
公开(公告)号：US06384061B1
公开(公告)日：2002-05-07
申请号：US09463551
申请日：2000-03-30
申请人： Jin Ho Lee , Jong Sung Koh , Jong Hyun Kim , Hyun Il Lee , Won Hee Jung , Seong Gu Ro , You Seong Shin , Sang Woong Kim , Ki Won Park , Tae Hwan Kwak , Kyung Duk Moon , Hyun Ho Chung
发明人： Jin Ho Lee , Jong Sung Koh , Jong Hyun Kim , Hyun Il Lee , Won Hee Jung , Seong Gu Ro , You Seong Shin , Sang Woong Kim , Ki Won Park , Tae Hwan Kwak , Kyung Duk Moon , Hyun Ho Chung
IPC分类号： A61K3144
CPC分类号： C07D401/14 , C07D233/76 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.
摘要翻译： 本发明涉及式（I）所示的新型乙内酰脲化合物，其表现出对法呢基转移酶的抑制活性，因此可用作抗癌剂或其药学上可接受的盐，其中R1，R2，R3和R4 如本申请中所定义。 本发明还涉及制备式（I）化合物的方法，以及包含式（I）化合物作为活性成分的抗癌组合物。
-
9.发明授权Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof 失效具有法呢基转移酶抑制活性的咪唑衍生物及其制备方法公开(公告)号：US06268363B1
公开(公告)日：2001-07-31
申请号：US09554646
申请日：2000-05-17
申请人： Hyun Il Lee , Jong Sung Koh , Jin Ho Lee , Won Hee Jung , You Seung Shin , Hyun Ho Chung , Jong Hyun Kim , Seong Gu Ro , Tae Saeng Choi , Shin Wu Jeong , Tae Hwan Kwak , In Ae Ahn , Hyun Sung Kim , Sun Hwa Lee , Kwi Hwa Kim , Jung Kwon Yoo
发明人： Hyun Il Lee , Jong Sung Koh , Jin Ho Lee , Won Hee Jung , You Seung Shin , Hyun Ho Chung , Jong Hyun Kim , Seong Gu Ro , Tae Saeng Choi , Shin Wu Jeong , Tae Hwan Kwak , In Ae Ahn , Hyun Sung Kim , Sun Hwa Lee , Kwi Hwa Kim , Jung Kwon Yoo
IPC分类号： A61K314178
CPC分类号： C07D401/14 , C07D403/06 , C07D405/14 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.
摘要翻译： 本发明涉及式（1）所示的新型咪唑衍生物，其表现出对法呢基转移酶的抑制活性或其药学上可接受的盐或异构体，其中A，n1和Y在本说明书中定义; 涉及制备式（1）化合物的方法; 用于制备式（1）化合物的中间体; 以及包含式（1）化合物作为活性成分的药物组合物。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.017 秒)