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    Apparatus for desorption and ionization of analytes
    1.
    发明授权
    Apparatus for desorption and ionization of analytes 失效
    分析物的解吸和电离装置

    公开(公告)号：US08748193B2

    公开(公告)日：2014-06-10

    申请号：US12372478

    申请日：2009-02-17

    Applicant: T. William Hutchens ,  Tai-Tung Yip

    Inventor： T. William Hutchens ,  Tai-Tung Yip

    IPC: G01N33/537

    CPC classification number: H01J49/164 ,  G01N33/68 ,  G01N33/6851 ,  H01J49/0418 ,  Y10T436/143333 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/255

    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.

    Abstract translation: 本发明一般涉及用于解析和离子化分析物的方法和装置，用于通过诸如质谱法或生物传感器等方法的后续科学分析。 更具体地，本发明涉及质谱领域，特别涉及用于分析大分子如蛋白质或生物分子的基质辅助激光解吸/电离，飞行时间质谱的类型。 最具体地，本发明涉及样品探针几何形状，样品探针组合物和样品探针表面化学物质，其能够使分析物（包括完整的大分子）从探针表面直接选择性捕集和解吸到气体（蒸汽）相中而不添加化学物质 矩阵。

    BIOMARKERS FOR PERIPHERAL ARTERY DISEASE
    2.
    发明申请
    BIOMARKERS FOR PERIPHERAL ARTERY DISEASE 审中-公开
    外周动脉疾病的生物标志物

    公开(公告)号：US20110313681A1

    公开(公告)日：2011-12-22

    申请号：US13218012

    申请日：2011-08-25

    Applicant: Eric T. Fung ,  John P. Cooke ,  Xiao-Ying Meng ,  Tai-Tung Yip ,  Fujan Zhang

    Inventor： Eric T. Fung ,  John P. Cooke ,  Xiao-Ying Meng ,  Tai-Tung Yip ,  Fujan Zhang

    IPC: G06F19/00 ,  C07K14/435 ,  C07K16/18 ,  C07K14/76

    CPC classification number: G01N33/6893 ,  G01N2800/32 ,  G01N2800/324

    Abstract: This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients.

    Abstract translation: 本发明提供了血浆中的浓度与患有血浆样品的患者中存在或不存在PAD有关的生物标志物。 本发明还提供用于区分长跛行者的PAD患者和不是PAD患者的生物标志物。 此外，本发明提供了用于鉴定另外的生物标志物的方法，用于检测患者中生物标志物的方法，以及用于鉴定与生物标志物相互作用并可用于预防或治疗患者中PAD的药剂（包括药剂）的方法。

    Polypeptides Related to Natriuretic Peptides and Methods of Their Identification and Use
    3.
    发明申请
    Polypeptides Related to Natriuretic Peptides and Methods of Their Identification and Use 审中-公开
    与利尿钠肽相关的多肽及其鉴定和使用方法

    公开(公告)号：US20080160540A1

    公开(公告)日：2008-07-03

    申请号：US12013606

    申请日：2008-01-14

    Applicant: Kenneth F. Buechler ,  Eric Thomas Fung ,  Tai-Tung Yip

    Inventor： Kenneth F. Buechler ,  Eric Thomas Fung ,  Tai-Tung Yip

    IPC: G01N33/53 ,  C07K16/18

    CPC classification number: G01N33/74 ,  G01N2500/04

    Abstract: The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.

    Abstract translation: 本发明涉及与靶向所需感兴趣的多肽的抗体结合的多肽的鉴定和使用。 使用利尿钠肽及其前体，特别是BNP作为实例，本发明描述了与生物样品中产生的许多利钠肽片段，最优选血液衍生的样品，其结合针对BNP的抗体。 因为这样的片段的产生是一个持续的过程，其可以是尤其是引发利钠肽释放到组织中的事件发生之间经过的时间与获得或分析样品的时间的函数; 样品采集与样品分析时间之间的经过时间; 有关组织样本的类型; 储存条件; 存在蛋白水解酶的数量; 当设计用于一种或多种利钠肽的测定法和进行这样的测定时，可以使用这样的片段，以便提供准确的预后或诊断结果。

    Method and apparatus for desorption and ionization of analytes
    8.
    发明授权
    Method and apparatus for desorption and ionization of analytes 失效

    公开(公告)号：US06734022B2

    公开(公告)日：2004-05-11

    申请号：US09809657

    申请日：2001-03-15

    Applicant: T. William Hutchens ,  Tai-Tung Yip

    Inventor： T. William Hutchens ,  Tai-Tung Yip

    IPC: G01N33537

    CPC classification number: H01J49/0418 ,  G01N1/405 ,  G01N33/6851 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/255

    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.

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