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    Coenzyme Q compositions persisting in blood
    1.
    发明授权
    Coenzyme Q compositions persisting in blood 有权
    辅酶Q组合物持续存在血液

    公开(公告)号：US07708990B2

    公开(公告)日：2010-05-04

    申请号：US11085181

    申请日：2005-03-22

    申请人： Kenji Fujii ,  Taizo Kawabe ,  Hiroshi Kubo

    发明人： Kenji Fujii ,  Taizo Kawabe ,  Hiroshi Kubo

    IPC分类号： A61K38/43 ,  A01N31/14

    CPC分类号： A61K31/122 ,  Y10S514/824 ,  Y10S514/878 ,  Y10S514/879

    摘要： The object of the present invention is to provide a composition maintaining a blood coenzyme Q concentration at a high level in blood for a prolonged period of time, in order to surely attain an effect of coenzyme Q, which can be expected to manifest a superior effect in maintaining health in humans and animals.By using a composition which comprises a coenzyme Q being a mixture of a reduced coenzyme Q and an oxidized coenzyme Q with the proportion of the reduced coenzyme Q to the whole coenzyme Q of more than 95% by weight, the present invention can attain a high maximum blood concentration of a coenzyme Q as well as long maintenance of high concentration of coenzyme Q in blood for a prolonged period of time, and the area under the blood concentration curve (AUC) can be expanded.

    摘要翻译： 本发明的目的是提供一种维持血液辅酶Q浓度在血液中长时间保持的组合物，以确保达到辅酶Q的效果，其可以预期表现出优异的效果 维持人类和动物的健康。 通过使用包含还原型辅酶Q和还原型辅酶Q的还原型辅酶Q与整个辅酶Q的比例大于95重量％的辅酶Q的混合物的组合物，本发明可以达到高 辅酶Q的最大血液浓度以及血液中长时间维持高浓度辅酶Q长时间，血液浓度曲线下面积（AUC）可以扩大。

    Composition Containing Reduced Coenzyme Q
    2.
    发明申请
    Composition Containing Reduced Coenzyme Q 审中-公开
    含有还原型辅酶Q的组合物

    公开(公告)号：US20070243180A1

    公开(公告)日：2007-10-18

    申请号：US10577211

    申请日：2004-10-22

    申请人： Hozumi Tanaka ,  Kenji Fujii ,  Taizo Kawabe

    发明人： Hozumi Tanaka ,  Kenji Fujii ,  Taizo Kawabe

    IPC分类号： A61K31/047 ,  C07C39/04 ,  C08B37/16

    CPC分类号： A61K9/1652 ,  A23V2002/00 ,  A61K31/09 ,  A23V2250/314

    摘要： It is an object of the present invention to provide a reduced coenzyme Q, as a composition capable of being stably stored and, at the same time, soluble in water, which has not been used for industrial application because of its auto oxidation and lipophilic property. A reduced coenzyme Q-containing composition capable of being stored in a refrigerator or at room temperature for a prolonged period of time and of being soluble in water can be prepared by contacting or mixing the reduced coenzyme Q and a cyclodextrin to obtain a clathrated compound or by mixing an antioxidant, the reduced coenzyme Q and the cyclodextrin under an appropriate condition.

    摘要翻译： 本发明的目的是提供还原型辅酶Q作为能够稳定储存的组合物，并且同时可溶于水，因为其自身氧化和亲油性没有被用于工业应用 。 可以通过使还原型辅酶Q和环糊精接触或混合来制备能够在冰箱或室温下长时间储存​​并且可溶于水的还原型辅酶Q组合物，以获得包合的化合物或 通过在适当的条件下混合抗氧化剂，还原型辅酶Q和环糊精。

    DERMAL COMPOSITIONS CONTAINING COENZYME Q AS THE ACTIVE INGREDIENT
    4.
    发明申请
    DERMAL COMPOSITIONS CONTAINING COENZYME Q AS THE ACTIVE INGREDIENT 审中-公开
    含有COENZYME Q的组合物作为活性成分

    公开(公告)号：US20110070213A1

    公开(公告)日：2011-03-24

    申请号：US12954356

    申请日：2010-11-24

    申请人： Kenji FUJII ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    发明人： Kenji FUJII ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    IPC分类号： A61K31/09 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P17/08

    CPC分类号： A61Q19/00 ,  A61K8/347 ,  A61K8/355 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/05 ,  A61K31/122 ,  A61K47/10 ,  A61K2800/70 ,  A61L15/44 ,  A61L2300/216 ,  A61Q19/10

    摘要： The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application.The present invention is further provides a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above-mentioned therapeutic composition for skin diseases, or a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above therapeutic agent for skin diseases other than the oxidized coenzyme Q represented by the formula (1) and other than the reduced coenzyme Q represented by the formula (2) in parallel with a therapeutic composition for skin diseases.

    摘要翻译： 本发明提供了一种用于真皮应用的组合物，其包含作为活性成分的由式（1）表示的氧化型辅酶Q：其中n表示1〜12的整数，和/或由下式表示的还原型辅酶Q 式（2）：其中n表示1〜12的整数，相对于组合物的总量，氧化型辅酶Q和还原型辅酶Q的总含量为0.01〜99重量％。 本发明还提供了一种皮肤病的治疗组合物，化妆品组合物，皮肤保健组合物和浴盐组合物，每种组合物包含上述用于真皮应用的组合物。 本发明还提供了一种治疗皮肤病的方法，其包括向患有皮肤病的患者应用上述皮肤病治疗组合物或皮肤病治疗方法， 对于患有皮肤病的患者，除了由式（1）表示的氧化型辅酶Q以外，除了式（2）所示的还原型辅酶Q以外，还可以使用与上述治疗组合物平行的上述皮肤病治疗剂， 皮肤病。

    COMPOSITION OF HIGH ABSORBABILITY FOR ORAL ADMINISTRATION COMPRISING OXIDIZED COENZYME Q10
    7.
    发明申请
    COMPOSITION OF HIGH ABSORBABILITY FOR ORAL ADMINISTRATION COMPRISING OXIDIZED COENZYME Q10 审中-公开
    含有氧化聚苯乙烯的口服药物Q10的高可吸收性组合物Q10

    公开(公告)号：US20080145411A1

    公开(公告)日：2008-06-19

    申请号：US11867347

    申请日：2007-10-04

    申请人： Yoshiyuki Shinagawa ,  Taizo Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

    发明人： Yoshiyuki Shinagawa ,  Taizo Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

    IPC分类号： A61K9/00 ,  A61K38/43 ,  A61K9/48 ,  A61K31/122

    CPC分类号： A61K31/122 ,  A23K20/10 ,  A23K20/111 ,  A23K20/158 ,  A23K50/40 ,  A23L29/06 ,  A23L29/10 ,  A23L33/10 ,  A23L33/17 ,  A61K9/4858

    摘要： The present invention provides a method of increasing the absorbability of oxidized coenzyme Q10 by preparing the oxidized coenzyme Q10 as a composition in the presence of a lysolecithin and an oil and fat. The composition of the present invention comprising oxidized coenzyme Q10, a lysolecithin and an oil and fat, wherein the weight ratio of the lysolecithin to the oxidized coenzyme Q10 is not less than 0.7, shows superior absorption of oxidized coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.

    摘要翻译： 本发明提供了通过在溶血卵磷脂和油脂中存在下制备氧化型辅酶Q 10作为组合物来提高氧化型辅酶Q 10的吸收性的方法 。 包含氧化型辅酶Q 10，溶血卵磷脂和油脂的本发明组合物，其中溶血卵磷脂与氧化型辅酶Q 10重量比不小于 超过0.7，表现出优异的氧化型辅酶Q 10的吸收，可用于食品，具有营养功能的食物，特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，宠物 食品，化妆品，医药产品，治疗药物，预防药物等。

    Coenzyme Q compositions persisting in blood
    8.
    发明申请
    Coenzyme Q compositions persisting in blood 有权
    辅酶Q组合物持续存在血液

    公开(公告)号：US20060073131A1

    公开(公告)日：2006-04-06

    申请号：US11085181

    申请日：2005-03-22

    申请人： Kenji Fujii ,  Taizo Kawabe ,  Hiroshi Kubo

    发明人： Kenji Fujii ,  Taizo Kawabe ,  Hiroshi Kubo

    IPC分类号： A61K38/43 ,  A61K31/12

    CPC分类号： A61K31/122 ,  Y10S514/824 ,  Y10S514/878 ,  Y10S514/879

    摘要： The object of the present invention is to provide a composition maintaining a blood coenzyme Q concentration at a high level in blood for a prolonged period of time, in order to surely attain an effect of coenzyme Q, which can be expected to manifest a superior effect in maintaining health in humans and animals. By using a composition which comprises a coenzyme Q being a mixture of a reduced coenzyme Q and an oxidized coenzyme Q with the proportion of the reduced coenzyme Q to the whole coenzyme Q of more than 95% by weight, the present invention can attain a high maximum blood concentration of a coenzyme Q as well as long maintenance of high concentration of coenzyme Q in blood for a prolonged period of time, and the area under the blood concentration curve (AUC) can be expanded.

    摘要翻译： 本发明的目的是提供一种维持血液辅酶Q浓度在血液中长时间保持的组合物，以确保达到辅酶Q的效果，其可以预期表现出优异的效果 维持人类和动物的健康。 通过使用包含还原型辅酶Q和还原型辅酶Q的还原型辅酶Q与整个辅酶Q的比例大于95重量％的辅酶Q的混合物的组合物，本发明可以达到高 辅酶Q的最大血液浓度以及血液中长时间维持高浓度辅酶Q长时间，血液浓度曲线下面积（AUC）可以扩大。

    Method and composition for inhibiting arteriosclerosis
    9.
    发明授权
    Method and composition for inhibiting arteriosclerosis 有权
    抑制动脉硬化的方法和组合物

    公开(公告)号：US06939897B2

    公开(公告)日：2005-09-06

    申请号：US10892164

    申请日：2004-07-16

    申请人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    发明人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

    IPC分类号： A61K31/05 ,  A61K45/00 ,  A61K45/06 ,  A61P9/10 ,  A61P43/00 ,  A61K31/12 ,  A61K31/35 ,  A61K31/405

    CPC分类号： A61K45/06 ,  A61K31/09 ,  A61K31/22 ,  A61K2300/00

    摘要： The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy. A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Q10 represented by the following formula (1), and a composition for inhibiting arteriosclerosis containing both a cholesterol-lowering agent and said reduced coenzyme Q10.

    摘要翻译： 本发明的目的是提供一种方法和组合物，其通过使用抗高脂血症或降胆固醇药物抑制血浆LDL的抗氧化活性或甚至增加，从而更有效地回收 确保增强的抗动脉硬化功效。 一种抑制动脉硬化的方法，其包括使用降胆固醇剂和由下式（1）表示的还原型辅酶Q 10的组合，以及抑制动脉硬化的组合物，其含有胆固醇 - 降低剂和所述还原型辅酶Q 10。