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    Spiro compounds having stearoyl-CoA desaturase action
    4.
    发明授权
    Spiro compounds having stearoyl-CoA desaturase action 有权
    具有硬脂酰-CoA去饱和酶作用的螺环化合物

    公开(公告)号：US08575167B2

    公开(公告)日：2013-11-05

    申请号：US12449320

    申请日：2008-02-05

    申请人： Takahiko Taniguchi ,  Kenichi Miyata ,  Osamu Kubo

    发明人： Takahiko Taniguchi ,  Kenichi Miyata ,  Osamu Kubo

    IPC分类号： A61K31/50 ,  C07D401/00 ,  A61P3/04 ,  A61P3/06 ,  A61P7/12 ,  A61P9/12 ,  A61P9/04 ,  A61P9/00 ,  A61P9/10

    CPC分类号： C07D401/04 ,  C07D409/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/10 ,  C07D491/107 ,  C07D498/10

    摘要： The present invention aims to provide a novel SCD inhibitor.The present invention relate to SCD inhibitor comprising A compound represented by the formula (I) wherein R is an optionally substituted cyclic group or an optionally substituted carbamoyl group, provided that R is not an optionally substituted 7-pyrido[2,3-d]pyrimidyl group; ring A is an optionally further substituted pyridazine ring; R1, R2, R3, R4, R11, R12, R13 and R14 are each independently a hydrogen atom or a substituent, or R1 and R11 in combination, R2 and R12 in combination, R3 and R13 in combination, or R4 and R14 in combination optionally form an oxo group, or R2 and R4 in combination optionally form a bond or an alkylene cross-linkage; m and n are each independently an integer of 0 to 2; ring B is an optionally substituted ring, provided that the two atoms constituting ring B, which are adjacent to the spiro carbon atom, are not oxygen atoms at the same time, or a salt thereof, or a prodrug thereof.

    摘要翻译： 本发明旨在提供一种新型的SCD抑制剂。 本发明涉及包含由式（I）表示的化合物的SCD抑制剂，其中R是任选取代的环状基团或任选取代的氨基甲酰基，条件是R不是任选取代的7-吡啶并[2,3-d] 嘧啶基; 环A是任选进一步取代的哒嗪环; R 1，R 2，R 3，R 4，R 11，R 12，R 13和R 14各自独立地为氢原子或取代基，或R 1和R 11组合，R 2和R 12组合，R 3和R 13组合，或R 4和R 14组合 任选地形成氧代基团，或者R 2和R 4组合任选地形成键或亚烷基交联; m和n各自独立地为0〜2的整数。 环B是任选取代的环，条件是与螺环碳原子相邻的构成环B的两个原子不是同时为氧原子，或其盐或其前药。

    Pyridazinone compounds
    6.
    发明授权
    Pyridazinone compounds 有权
    哒嗪酮化合物

    公开(公告)号：US08435995B2

    公开(公告)日：2013-05-07

    申请号：US13543332

    申请日：2012-07-06

    申请人： Takahiko Taniguchi ,  Jun Kunitomo

    发明人： Takahiko Taniguchi ,  Jun Kunitomo

    IPC分类号： A61K31/50 ,  A61K31/501 ,  C07D401/00

    CPC分类号： C07D403/04 ,  A61K9/2059 ,  C07D401/14 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14

    摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

    摘要翻译： 本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。 式（I0）的化合物，其中R1表示取代基; R2表示氢原子或取代基; R3表示氢原子或取代基; 环A表示可被取代的芳环，环B表示可被取代的5元杂芳环或其盐。

    1-phenyl-3-pyrazolylpyridazin-4(1H)-one compound
    7.
    发明授权
    1-phenyl-3-pyrazolylpyridazin-4(1H)-one compound 有权
    1-苯基-3-吡唑基哒嗪-4（1H） - 酮化合物

    公开(公告)号：US08354411B2

    公开(公告)日：2013-01-15

    申请号：US13148172

    申请日：2010-02-04

    申请人： Takahiko Taniguchi ,  Jun Kunitomo

    发明人： Takahiko Taniguchi ,  Jun Kunitomo

    IPC分类号： A61K31/50 ,  A61K31/501 ,  C07D401/00

    CPC分类号： C07D403/04 ,  A61K9/2059 ,  C07D401/14 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14

    摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

    摘要翻译： 本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。 式（I0）的化合物，其中R1表示取代基; R2表示氢原子或取代基; R3表示氢原子或取代基; 环A表示可被取代的芳环，环B表示可被取代的5元杂芳环或其盐。

    Bumper absorber
    9.
    发明授权
    Bumper absorber 有权
    缓冲器

    公开(公告)号：US07677616B2

    公开(公告)日：2010-03-16

    申请号：US12038244

    申请日：2008-02-27

    申请人： Takahiko Taniguchi ,  Seiho Yonezawa ,  Soshi Mitsuyama ,  Hiroyasu Miyamoto

    发明人： Takahiko Taniguchi ,  Seiho Yonezawa ,  Soshi Mitsuyama ,  Hiroyasu Miyamoto

    IPC分类号： B60R19/34

    CPC分类号： B60R19/18 ,  B60R2019/1873

    摘要： A bumper absorber includes an upper leg and a lower leg, each of which extends in a longitudinal direction of an automobile, and a spanning portion. The spanning portion connects the upper leg and the lower leg, and faces an outer surface side of the bumper absorber in a longitudinal direction of the automobile. Each of the upper leg and the lower leg includes a buckling inductive portion that serves as a starting point of the buckling that is caused when the spanning portion receives an impact load. The buckling inductive portion is formed as an angular transition portion in which the angle of inclination between inner side surfaces changes. The inner side surfaces mutually face between the upper leg and the lower leg that include the buckling inductive portion.

    摘要翻译： 保险杠吸收器包括大腿和小腿，每个腿在汽车的纵向方向上延伸，并且跨越部分。 跨越部分连接上腿和小腿，并且在汽车的纵向方向上面对保险杠吸收体的外表面侧。 上腿和下腿中的每一个包括作为在跨越部分接收冲击载荷时引起的屈曲起始点的屈曲感应部分。 屈曲感应部形成为内侧面的倾斜角度变化的角度过渡部。 内侧表面相互面对在包括屈曲感应部分的上腿和下腿之间。