公开(公告)号：US5008243A

公开(公告)日：1991-04-16

申请号：US285664

申请日：1988-12-16

申请人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

发明人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

IPC分类号： A61K38/00 ,  C07K14/375

CPC分类号： C07K14/375 ,  A61K38/00 ,  Y10S435/911

摘要： Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretics activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300,000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

公开(公告)号：US4681877A

公开(公告)日：1987-07-21

申请号：US562003

申请日：1983-12-16

申请人： Shigeaki Muto ,  Takao Ando ,  Takayoshi Fujii ,  Akihiko Kanno ,  Yoko Onishi ,  Isamu Motokawa ,  Takao Furusho ,  Chikao Yoshikumi

发明人： Shigeaki Muto ,  Takao Ando ,  Takayoshi Fujii ,  Akihiko Kanno ,  Yoko Onishi ,  Isamu Motokawa ,  Takao Furusho ,  Chikao Yoshikumi

IPC分类号： A61K31/545 ,  C07D501/36 ,  C07D501/56

CPC分类号： C07D501/36

摘要： Disclosed herein are 7-beta-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-(2-amino-1,3,4-thiadiazolyl-5-thiomethyl)-3-cepheme-4-carboxylic acid, salts thereof and pivaloyloxymethyl ester thereof, and a pharmaceutical composition containing the same as an active ingredient.

摘要翻译： 本文公开了7-β-（2-（2-氨基-4-噻唑基）-2-甲氧基亚氨基乙酰氨基] -3-（2-氨基-1,3,4-噻二唑基-5-硫代甲基）-3-头孢烯-4 - 羧酸，其盐和新戊酰氧基甲酯，以及含有它们作为活性成分的药物组合物。

公开(公告)号：US4496574A

公开(公告)日：1985-01-29

申请号：US419077

申请日：1982-09-16

申请人： Shigeaki Muto ,  Kouichi Niimura ,  Takao Ando ,  Akihiko Kanno ,  Takao Furusho ,  Chikao Yoshikumi

发明人： Shigeaki Muto ,  Kouichi Niimura ,  Takao Ando ,  Akihiko Kanno ,  Takao Furusho ,  Chikao Yoshikumi

IPC分类号： A61K31/43 ,  A61K31/70 ,  A61K31/7024 ,  A61P31/04 ,  C07D499/00 ,  C07D499/40 ,  C07D499/46 ,  C07D499/60 ,  C07D499/64 ,  C07D499/68 ,  C07H13/10

CPC分类号： C07D499/00

摘要： A penicillin derivative having an antibacterial activity similar to a penicillin antibiotic in a living body without affecting the intestinal bacterial colonies, a process for preparing the derivative and a pharmaceutical composition in a dosage unit form containing the derivative as an active ingredient are disclosed.

公开(公告)号：US4446137A

公开(公告)日：1984-05-01

申请号：US419076

申请日：1982-09-16

申请人： Shigeaki Muto ,  Kouichi Niimura ,  Takao Ando ,  Masahiko Fujii ,  Takao Furusho ,  Chikao Yoshikumi

发明人： Shigeaki Muto ,  Kouichi Niimura ,  Takao Ando ,  Masahiko Fujii ,  Takao Furusho ,  Chikao Yoshikumi

IPC分类号： A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/34

CPC分类号： C07D501/34

摘要： A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 atoms or an alkali metal and R is --CH.sub.2 COOR', --CH.sub.2 CH.sub.2 SR', ##STR2## or --CH.sub.2 CH.sub.2 COOR' wherein R' is defined above. A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.

摘要翻译： 具有通式（I）的化合物衍生自头孢菌素; 其中R'为氢原子，具有1-4个碳原子的烷基或碱金属，R为-CH2COOR'，-CH2CH2SR'，“IMA”或-CH2CH2COOR'，其中R'定义如上 。 含有该化合物的药物组合物的抗菌活性优异，活性酶活性在生物体中回收的活性虽然化合物本身对生物体中的有益细菌菌落显示低活性。

公开(公告)号：US5089481A

公开(公告)日：1992-02-18

申请号：US613971

申请日：1990-11-15

申请人： Shigeaki Muto ,  Koichi Niimura ,  Minoru Oohara ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Kunitaka Hirose ,  Junji Kakuchi ,  Norifumi Sugita ,  Takao Furusho ,  Chikao Yoshikumi ,  Masaaki Takahashi

发明人： Shigeaki Muto ,  Koichi Niimura ,  Minoru Oohara ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Kunitaka Hirose ,  Junji Kakuchi ,  Norifumi Sugita ,  Takao Furusho ,  Chikao Yoshikumi ,  Masaaki Takahashi

IPC分类号： A61K35/66 ,  A61K35/74 ,  A61K36/02 ,  A61K36/03 ,  A61K36/04 ,  A61K36/05 ,  A61K38/00 ,  C07K4/08 ,  C08B37/00 ,  C12P19/26 ,  C12P21/00

CPC分类号： C12P21/005 ,  A61K36/03 ,  A61K36/04 ,  A61K36/05 ,  C08B37/0087 ,  Y10S435/946 ,  Y10S514/885

摘要： Disclosed herein are polysaccharides extracted from marine algae and an antiviral drug containing as active ingredient polysaccharides extracted from seaweeds.

摘要翻译： 本文公开了从海藻提取的多糖和含有作为活性成分的从海藻提取的多糖的抗病毒药物。

公开(公告)号：US4985543A

公开(公告)日：1991-01-15

申请号：US207836

申请日：1988-06-17

申请人： Norifumi Sugita ,  Koichi Niimura ,  Yoshiharu Oguchi ,  Kunitaka Hirose ,  Kenichi Matsunaga ,  Minoru Oohara ,  Shigeaki Muto ,  Junji Kakuchi ,  Takao Furusho ,  Chikao Yoshikumi ,  Masaaki Takahashi

发明人： Norifumi Sugita ,  Koichi Niimura ,  Yoshiharu Oguchi ,  Kunitaka Hirose ,  Kenichi Matsunaga ,  Minoru Oohara ,  Shigeaki Muto ,  Junji Kakuchi ,  Takao Furusho ,  Chikao Yoshikumi ,  Masaaki Takahashi

IPC分类号： A61K36/00 ,  A61K36/07 ,  A61K36/18 ,  A61K36/36 ,  A61K36/47 ,  A61K36/48 ,  A61K38/00 ,  A61P31/12 ,  C07K1/14 ,  C07K14/415 ,  C07K14/42

CPC分类号： C07K14/42 ,  A61K36/36 ,  A61K36/47 ,  A61K36/48

摘要： Disclosed herein are lectins extracted form a plant of the class Dicotyledoneae and an antiretoviral drug comprising as an active ingredient an effective amount of the lectins.

公开(公告)号：US4758558A

公开(公告)日：1988-07-19

申请号：US864574

申请日：1986-05-19

申请人： Akihiko Kanno ,  Shigeaki Muto ,  Koichi Niimura ,  Takao Ando ,  Takayoshi Fujii ,  Masahiko Fujii ,  Takao Furusho ,  Chikao Yoshikumi

发明人： Akihiko Kanno ,  Shigeaki Muto ,  Koichi Niimura ,  Takao Ando ,  Takayoshi Fujii ,  Masahiko Fujii ,  Takao Furusho ,  Chikao Yoshikumi

IPC分类号： A61K31/545 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/36

CPC分类号： C07D501/20

摘要： Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R.sup.1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R.sup.2 represents a hydrogen atom, an acetoxy group or a (5-methyl-1,3,4-thiadiazol-2-yl)thio group; R.sup.3 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1, n is 0, 1 or 2 and the carboxyl group may have been converted to a salt or an ester thereof; p is 0, 1 or 2 and X represents carbon atom or nitrogen atom, and antibiotics comprising the derivatives of substituted cephalosporanic acid represented by the formula (I).

摘要翻译： 本文公开了由式（I）表示的取代的头孢烷酸的衍生物：其中R1表示4-吡啶硫基甲基，α-氨基苄基，氰基甲基或1-四唑基甲基; R2表示氢原子，乙酰氧基或（5-甲基-1,3,4-噻二唑-2-基）硫基; R 3表示氢原子，羟基，氨基甲酰基，具有1〜4个碳原子的烷基或 - （CONH）m（CH 2）n -COOH，其中m为0或1，n为0,1或2， 羧基可能已经转化为其盐或酯; p是0,1或2，X表示碳原子或氮原子，以及包含由式（I）表示的取代的头孢烷酸的衍生物的抗生素。

公开(公告)号：US4734409A

公开(公告)日：1988-03-29

申请号：US702135

申请日：1985-02-15

申请人： Shigeaki Muto ,  Chikao Yoshikumi ,  Takao Furusho ,  Isamu Motokawa ,  Yoko Onishi ,  Akihiko Kanno ,  Takayoshi Fujii ,  Takao Ando

发明人： Shigeaki Muto ,  Chikao Yoshikumi ,  Takao Furusho ,  Isamu Motokawa ,  Yoko Onishi ,  Akihiko Kanno ,  Takayoshi Fujii ,  Takao Ando

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/36

CPC分类号： C07D501/36

摘要： Disclosed herein are a cephalosporin derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents a halogenoalkyl group, a salt and ester thereof, a process for producing the same, and a pharmaceutical composition and an antibacterial agent comprising the same.

摘要翻译： 本文公开了由式（I）表示的头孢菌素衍生物：其中R 1表示卤代烷基，其盐和酯，其制备方法，药物组合物和抗菌剂 包含其的药剂。

公开(公告)号：US4690920A

公开(公告)日：1987-09-01

申请号：US563515

申请日：1983-12-20

申请人： Akihiko Kanno ,  Shigeaki Muto ,  Koichi Niimura ,  Takao Ando ,  Takayoshi Fujii ,  Masahiko Fujii ,  Takao Furusho ,  Chikao Yoshikumi

发明人： Akihiko Kanno ,  Shigeaki Muto ,  Koichi Niimura ,  Takao Ando ,  Takayoshi Fujii ,  Masahiko Fujii ,  Takao Furusho ,  Chikao Yoshikumi

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/36 ,  C07D501/57

CPC分类号： C07D501/57

摘要： Disclosed herein are a derivative of a substituted cephalosporanic acid, represented by the formula (I): ##STR1## wherein p is 0, 1 or 2 and R.sup.1 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1; n is 0, 1 or 2 and the carboxyl group may have been converted to the salt or the ester thereof, and an antibiotic comprising a derivative of substituted cephalosporanic acid represented by the formula (I).

摘要翻译： 本文公开了由式（I）表示的取代头孢烷酸的衍生物：其中p为0,1或2，R 1表示氢原子，羟基，氨基甲酰基，烷基 具有1至4个碳原子的基团或 - （CONH）m（CH 2）n -COOH，其中m为0或1; n为0,1或2，羧基可以转化为其盐或其酯，以及包含由式（I）表示的取代头孢烷酸衍生物的抗生素。

公开(公告)号：US4663438A

公开(公告)日：1987-05-05

申请号：US715816

申请日：1985-03-25

申请人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Takao Furusho ,  Kenichi Matsunaga ,  Minoru Ohara ,  Akira Kobayashi

发明人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Takao Furusho ,  Kenichi Matsunaga ,  Minoru Ohara ,  Akira Kobayashi

IPC分类号： C12P21/00 ,  A61K36/07 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/37 ,  C07K14/375 ,  C07K14/41 ,  C12N1/00 ,  C12P1/06 ,  C12P9/00 ,  C07K15/14

CPC分类号： C07K14/375 ,  A61K38/00

摘要： Disclosed herein is a nucleic acid-containing glycoprotein having molecular weight of 5,000 to 300,000 as determined by ultracentrifugal method; the weight ratio of protein moiety thereof determined by Lowry-Folin's method to saccharide moiety thereof determined by phenol-sulfuric acid method of in the range of 50/50 to 80/20; N-terminal amino acid thereof consisting essentially of tyrosine, leucine or alanine; leucine-phenylalanine-valine as amino acid sequence at C-terminal thereof; the elementary composition consisting essentially of 35.2 to 49.3% of C, 4.8 to 8.0% of H, 4.3 to 12.3% of N, trace to 2.5% of S, trace to 1.2% of P and the balance of O; the isoelectric point of in the range of pH 2.5 to 5.0; and nucleic acid as a component.

摘要翻译： 本文公开了通过超速离心法测定的分子量为5,000〜300,000的含核酸的糖蛋白; 通过Lowry-Folin法测定的蛋白质部分的重量比通过酚 - 硫酸法测定的糖部分在50/50至80/20范围内; 其N-末端氨基酸主要由酪氨酸，亮氨酸或丙氨酸组成; 亮氨酸 - 苯丙氨酸 - 缬氨酸作为C末端的氨基酸序列; 基本组成基本上由C的35.2至49.3％，H的4.8至8.0％，N的4.3至12.3％，S的2.5％，P的1.2％和O的余量组成。 等电点在2.5〜5.0的范围内; 和核酸作为组分。