摘要:
Disclosed are quinolone derivatives characterized in that these have lower alkyl, cycloalkyl or the like at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene-CO2R0, —O-(lower alkylene which may be substituted with —CO2R0)-aryl or —O-lower alkenylene-CO2R0 (wherein R0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof, has excellent P2Y12 inhibitory activity. The quinolone derivatives have excellent platelet aggregation inhibitory activity. A method of using the compounds is also disclosed.
摘要翻译:公开了喹诺酮衍生物,其特征在于它们在1-位具有低级烷基,环烷基等; -N(R 0)C(O) - 低级亚烷基-CO 2 R 0,低级亚烷基-CO 2 R 0,低级亚烯基-CO 2 R O,-O-低级亚烷基-CO 2 R O,-O-(可被-CO 2 R 0取代的低级亚烷基) - 芳基或 O-低级亚烯基-CO 2 R 0(其中R 0是H或低级烷基)在3-位; 6位卤素; 分别被具有7位具有环结构的取代基取代的氨基或其药学上可接受的盐具有优异的P2Y12抑制活性。 喹诺酮衍生物具有优异的血小板聚集抑制活性。 还公开了使用该化合物的方法。
摘要:
A platelet aggregation inhibitor comprising a quinolone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a novel quinolone derivative or a pharmaceutically acceptable salt thereof useful as a platelet aggregation inhibitor.
摘要:
Switching of topics in video content is detected using a telop included in the image, and the content is segmented by topics.First a scene-change point where the scene changes significantly is detected in the video content on the basis of the switching of images. Then, an average image of frames one second before and after the scene-change point is produced. The average image is used to detect, in a highly accurate manner, whether or not a telop is displayed. Then, a section in which the same stationary telop is displayed is detected. Index information related to the time period of each section in which the same stationary telop is displayed is produced.
摘要:
2-Acylaminothiazole derivatives or salts thereof which have a platelet increasing activity based on an excellent human c-mpl-Ba/F3 cell growth function and a function of accelerating formation of megakaryocytic colonies and which are useful for treating thrombocytopenia are provided.
摘要:
A compound of the formula: ##STR1## wherein Ar is a phenyl group substituted with halogen, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.8 alkylthio, C.sub.1 -C.sub.8 alkylsulfonyl, nitro, trihalomethyl, cyano, C.sub.1 -C.sub.8 alkylamino, di(C.sub.1 -C.sub.8)-alkylamino, amino, hydroxyl, phenyl and/or phenoxy, a naphthyl group or a thienyl group optionally substituted with halogen, which is useful as an antifungal agent.
摘要:
An epoxy resin composition comprising (a) a cyclopentadiene-type hydrocarbon resin having a hydroxyl value of 100 to 300 obtained by copolymerizing a cyclopentadiene-type monomer and a hydroxyl-containing monolefinic monomer at elevated temperatures, (b) a polyol selected from the group consisting of epoxy resins containing at least two hydroxyl groups in the molecule and epoxy resin derivatives containing at least two hydroxyl groups in the molecule and obtained by the reaction of epoxy resins with alkanolamines, and (c) an isocyanate-type curing agent. The compositions have improved low temperature curability, acid resistance and water resistance while retaining the various desirable properties of epoxy resins such as chemical resistance and oil resistance, and which when used as paints, exhibit improved adhesion to an adherend and improved re-coating adhesion to the film formed thereon.
摘要:
An information processing device for analyzing motion and color of an image of a program and detecting shot sound and cheering of golf includes an extraction unit that extracts a notable interval which is a notable time interval of the program based on the motion of the image, a computation unit that computes a play scene level indicating a degree to which the notable interval is a play scene of the golf based on the motion, color and shot sound of the notable interval extracted by the extraction unit, and a determination unit that determines whether or not the notable interval is a play scene of the golf based on the play scene level computed by the computation unit.
摘要:
An information processing apparatus includes a selector for selecting removal information concerning contents to be removed, the removal information prepared on a per content basis for the contents to be removed and including a value uniquely determined from data within a data range of whole or part of a content to be removed, a first range that is the data range, and a second range that is a removal range represented by the position of the first range, a detector for detecting a range at a predetermined position within the whole content, having the same range as the first range contained in the removal information selected by the selector and the same value as the value uniquely determined and contained in the removal information, and a remover for removing a predetermined content based on the second range contained in the removal information selected by the selector if the detector detects the range at the predetermined position.
摘要:
A cephem compound represent by the general formula ##STR1## wherein, R.sup.1 represents hydrogen or lower alkyl, R.sup.2 and R.sup.3 are the same or different and each represents hydrogen or lower alkyl, R.sup.4 represents carboxyl or esterified carboxyl, and n represents 0 or 1, a salt of the cephem compound, and a process for producing the cephem compound or a salt thereof. Compounds of the above formula and salts thereof are valuable as antibacterial agents and are especially useful as oral drugs in the prevention or treatment of bacterial infectious diseases.
摘要:
An improvement is provided in and relating to a capacitance-type record medium wherein an information signal is recorded as a variation in the geometrical shape of its surface area, and is played back by the variation of the capacitance between its surface and an electrode of a reproducing stylus scanning the surface of the record medium relatively which occurs according to a variation in the geometrical shape of its surface area. The improvement consists in the fact that at least the surface area of the record medium is formed of (1) a material composed of an electrically conductive substance and a copolymer consisting of 98 to 65% by weight of vinyl chloride, 2 to 20% by weight of an alkyl vinyl ether with the alkyl group having 4 to 18 carbon atoms and/or a vinyl ester of a fatty acid in which the fatty acid residue has 4 to 18 carbon atoms and 0 to 15% by weight of another monomer copolymerizable with these compounds, or (2) a material composed of an electrically conductive substance and a polymer mixture consisting of at least two polymers in which the proportions of the constituent monomers are the same as in the aforesaid copolymer.