公开(公告)号：US08609235B2

公开(公告)日：2013-12-17

申请号：US12306341

申请日：2007-06-22

申请人： Yuji Hotta ,  Yasushi Suetsugu ,  Masanori Kikuchi ,  Toshiyuki Ikoma ,  Tomoya Kuwayama ,  Takashi Makabe ,  Junzo Tanaka

发明人： Yuji Hotta ,  Yasushi Suetsugu ,  Masanori Kikuchi ,  Toshiyuki Ikoma ,  Tomoya Kuwayama ,  Takashi Makabe ,  Junzo Tanaka

IPC分类号： B32B3/26 ,  A61F2/28

CPC分类号： A61L27/56 ,  A61L27/10 ,  A61L2430/02 ,  C04B35/043 ,  C04B35/111 ,  C04B35/447 ,  C04B35/46 ,  C04B35/486 ,  C04B35/565 ,  C04B35/62655 ,  C04B38/0074 ,  C04B2111/00836 ,  C04B2235/3212 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/77 ,  C04B2235/96 ,  C04B2235/9607 ,  Y10T428/249953 ,  Y10T428/249975 ,  C04B38/0003

摘要： Provision of a porous ceramic material which rapidly induces bone tissue formation and has practical strength.A porous ceramic material 11 having substantially unidirectionally oriented pores 12, a porosity of 40-90%, and an average open area of one pore of 0.05×10−3-50×10−3 mm2 both in a first sectional surface perpendicular to the pore 12 orientation direction and a second sectional surface parallel to the first sectional surface and 5 mm distant from the first sectional surface in the pore 12 orientation direction. Using the material 11, when a cylindrical test piece (diameter 3 mm×height 5 mm, the pore 12 array direction as a height direction) made of the material is dipped in polyethylene glycol up to 1 mm from one end thereof, polyethylene glycol permeates through the whole test piece preferably within 30 seconds.

摘要翻译： 提供一种快速诱导骨组织形成并具有实用强度的多孔陶瓷材料。 在垂直于第一截面的第一截面中，具有基本上单向取向的孔12，孔隙率为40-90％，孔的平均开放面积为0.05×10-3-50×10-3mm2的多孔陶瓷材料11 孔12取向方向和平行于第一截面的第二截面，并且在孔12的取向方向上离开第一截面的距离为5mm。 使用材料11，当将由该材料制成的圆柱形试验片（直径3mm×高度5mm，作为高度方向的孔12排列方向）从其一端浸入至聚乙二醇中至多1mm时，聚乙二醇渗透 通过整个试片最好在30秒内。

公开(公告)号：US20120111980A1

公开(公告)日：2012-05-10

申请号：US13382719

申请日：2010-07-02

申请人： Takashi Matsuo ,  Takashi Makabe

发明人： Takashi Matsuo ,  Takashi Makabe

IPC分类号： B02C1/12 ,  B02C1/02

CPC分类号： C04B38/0003 ,  B02C1/12 ,  C04B35/447 ,  C04B35/62655 ,  C04B35/64 ,  C04B2235/3206 ,  C04B2235/6023 ,  C04B2235/6567

摘要： A method for making calcium phosphate particles, the method including compressively pulverizing a molded body containing, as a principal component, a calcium phosphate material with a plurality of parallel extending needlelike projections. The molded body contains a plurality of void holes oriented in one direction and the pulverizing is carried out by moving the needlelike projections in a direction of protrusion, which is aligned with the one direction. Each needlelike projection has a diameter within a range of 1.0 to 2.0 mm and a number the needlelike projections per unitary surface area is within a range of 5 to 35 per cm2.

摘要翻译： 一种磷酸钙颗粒的制造方法，其特征在于，包括以多个平行延伸的针状突起为主要成分的含磷酸钙材料的成型体进行压缩粉碎。 成型体包含沿一个方向取向的多个空隙，并且通过沿与该一个方向对准的突出方向移动针状突起来进行粉碎。 每个针状突起的直径在1.0至2.0mm的范围内，并且每单位表面积的针状突起的数量在每平方厘米5至35的范围内。

公开(公告)号：US06558688B2

公开(公告)日：2003-05-06

申请号：US09768625

申请日：2001-01-25

申请人： Mototsugu Saishin ,  Mitsuo Tsukamoto ,  Takashi Makabe ,  Yoshimi Kakimaru ,  Takumi Fujitani ,  Tatsuhiko Higaki

发明人： Mototsugu Saishin ,  Mitsuo Tsukamoto ,  Takashi Makabe ,  Yoshimi Kakimaru ,  Takumi Fujitani ,  Tatsuhiko Higaki

IPC分类号： A61K906

CPC分类号： A61K31/79 ,  A61K31/765 ,  A61K31/785 ,  A61K31/787

摘要： The invention relates to an ocular tissue regeneration inducer which comprises, as an active ingredient, a hydrophilic polymer mainly composed of alkylene glycol units or vinyl monomeric units having a nondissociating hydrophilic group. The composition can induce the regeneration of ocular tissues such as the cornea, the crystalline lens, and the vitreous body.

摘要翻译： 本发明涉及一种眼组织再生诱导剂，其包含主要由具有非离解性亲水基团的亚烷基二醇单元或乙烯基单体单元构成的亲水性聚合物作为活性成分。 组合物可以诱导眼组织如角膜，晶状体和玻璃体的再生。

公开(公告)号：US08925840B2

公开(公告)日：2015-01-06

申请号：US13382719

申请日：2010-07-02

申请人： Takashi Matsuo ,  Takashi Makabe

发明人： Takashi Matsuo ,  Takashi Makabe

IPC分类号： B02C25/00 ,  C04B38/00 ,  B02C1/12 ,  C04B35/447 ,  C04B35/626 ,  C04B35/64

CPC分类号： C04B38/0003 ,  B02C1/12 ,  C04B35/447 ,  C04B35/62655 ,  C04B35/64 ,  C04B2235/3206 ,  C04B2235/6023 ,  C04B2235/6567

摘要： A method for making calcium phosphate particles, the method including compressively pulverizing a molded body containing, as a principal component, a calcium phosphate material with a plurality of parallel extending needlelike projections. The molded body contains a plurality of void holes oriented in one direction and the pulverizing is carried out by moving the needlelike projections in a direction of protrusion, which is aligned with the one direction. Each needlelike projection has a diameter within a range of 1.0 to 2.0 mm and a number the needlelike projections per unitary surface area is within a range of 5 to 35 per cm2.

摘要翻译： 一种磷酸钙颗粒的制造方法，其特征在于，包括以多个平行延伸的针状突起为主要成分的含磷酸钙材料的成型体进行压缩粉碎。 成型体包含沿一个方向取向的多个空隙，并且通过沿与该一个方向对准的突出方向移动针状突起来进行粉碎。 每个针状突起的直径在1.0至2.0mm的范围内，并且每单位表面积的针状突起的数量在每平方厘米5至35的范围内。

公开(公告)号：US20090281633A1

公开(公告)日：2009-11-12

申请号：US12306341

申请日：2007-06-22

申请人： Yuji Hotta ,  Yasushi Suetsugu ,  Masanori Kikuchi ,  Toshiyuki Ikoma ,  Tomoya Kuwayama ,  Takashi Makabe ,  Junzo Tanaka

发明人： Yuji Hotta ,  Yasushi Suetsugu ,  Masanori Kikuchi ,  Toshiyuki Ikoma ,  Tomoya Kuwayama ,  Takashi Makabe ,  Junzo Tanaka

IPC分类号： A61F2/02 ,  A61C13/08 ,  B29C39/02 ,  A61P43/00

CPC分类号： A61L27/56 ,  A61L27/10 ,  A61L2430/02 ,  C04B35/043 ,  C04B35/111 ,  C04B35/447 ,  C04B35/46 ,  C04B35/486 ,  C04B35/565 ,  C04B35/62655 ,  C04B38/0074 ,  C04B2111/00836 ,  C04B2235/3212 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/77 ,  C04B2235/96 ,  C04B2235/9607 ,  Y10T428/249953 ,  Y10T428/249975 ,  C04B38/0003

摘要： Provision of a porous ceramic material which rapidly induces bone tissue formation and has practical strength.A porous ceramic material 11 having substantially unidirectionally oriented pores 12, a porosity of 40-90%, and an average open area of one pore of 0.05×10−3-50×10−3 mm2 both in a first sectional surface perpendicular to the pore 12 orientation direction and a second sectional surface parallel to the first sectional surface and 5 mm distant from the first sectional surface in the pore 12 Orientation direction. Using the material 11, when a cylindrical test piece (diameter 3 mm×height 5 mm, the pore 12 array direction as a height direction) made of the material is dipped in polyethylene glycol up to 1 mm from one end thereof, polyethylene glycol permeates through the whole test piece preferably within 30 seconds.

摘要翻译： 提供一种快速诱导骨组织形成并具有实用强度的多孔陶瓷材料。 在垂直于孔12取向的第一截面中，具有基本上单向取向的孔12，孔隙率为40-90％，孔的平均开放面积为0.05×10 -3〜50×10 -3 mm 2的多孔陶瓷材料11 方向和平行于第一截面的第二截面，并且在孔12的方位方向上离开第一截面的距离为5mm。 使用材料11，当将由该材料制成的圆柱形试验片（直径3mm×高度5mm，作为高度方向的孔12排列方向）从其一端浸入到聚乙二醇中至多1mm时，聚乙二醇渗透通过 整个试片优选在30秒内。

公开(公告)号：US20050100631A1

公开(公告)日：2005-05-12

申请号：US10976910

申请日：2004-11-01

申请人： Naoya Baba ,  Takashi Makabe

发明人： Naoya Baba ,  Takashi Makabe

IPC分类号： G02C7/04 ,  B29C33/30 ,  B29C33/42 ,  B29C39/26 ,  B29D11/00 ,  B29K105/32 ,  B29L11/00

CPC分类号： B29D11/005 ,  B29D11/00057 ,  B29D11/00125

摘要： To provide a mold assembly for molding a contact lens having an excellent optical performance, which is accomplished by suppressing the axial misalignment brought about by the relative displacement between the male and female molds during the molding operation, the mold assembly has a lens molding cavity (30) defined therein when the male and female molds (1, 2) are joined together in an axial direction. A pair of mating faces (12, 22) are defined in the male and female molds (1, 2) at locations in the vicinity of outer peripheral edges of molding surface areas (11, 21) in the male and female molds (1, 2), respectively. Each face being in the form of an annular face lying substantially parallel to the axial direction. A pair of abutment faces (13, 23) are positioned radially outwardly of the mating faces (12, 22) and are, when the male and female molds (1, 2) are joined together, operable to position the male and female molds (1, 2) relative to each other in the axial direction.

摘要翻译： 为了提供一种用于模制具有优异光学性能的隐形眼镜的模具组件，其通过在模制操作期间通过抑制由阳模和阴模之间的相对位移引起的轴向未对准来实现，模具组件具有透镜模制腔 30），其中当阳模和阴模（1,2）在轴向方向连接在一起时限定在其中。 阳模和阴模（1，2）中的成形表面区域（11,21）的外周边缘附近的位置处，在阳模和阴模（1,2）中限定一对配合面（12,22） 2）。 每个面呈基本平行于轴向方向的环形面的形式。 一对邻接面（13,23）位于配合面（12,22）的径向外侧，并且当阳模和阴模（1,2）接合在一起时，可操作以定位阳模和阴模（ 1,2）在轴向上相对于彼此。

公开(公告)号：US06262208B1

公开(公告)日：2001-07-17

申请号：US09264004

申请日：1999-03-08

申请人： Takashi Makabe ,  Ikuo Omura

发明人： Takashi Makabe ,  Ikuo Omura

IPC分类号： C08F1820

CPC分类号： C08F226/06 ,  G02B1/043 ,  C08L39/04

摘要： Ocular lens materials is made from copolymers prepared by polymerizing a monomer mixture containing: (A) an N-vinyllactam; (B) a fluorine-containing unsaturated monomer; (C) a hydrophilic (meth)acrylamide; (D) a crosslinking agent having at least 2 (meth)acryloyloxy groups; and (E) a dicarboxylic acid divinyl ester. These ocular lens materials and ocular lenses causing no elution and have a high water-retaining capability, oxygen permeability, are excellent in transparency, resistance to deposition, mechanical strength, flexibility, safety, durability, correction of visual acuity, and comfort during wear.

摘要翻译： 眼透镜材料由通过聚合含有（A）N-乙烯基内酰胺的单体混合物制备的共聚物制备;（B）含氟不饱和单体;（C）亲水性（甲基）丙烯酰胺;（D）交联剂，其具有 至少2个（甲基）丙烯酰氧基; 和（E）二羧酸二乙烯基酯。这些眼透镜材料和眼镜片不会溶出并具有高的保水能力，透氧性，透明性，耐沉积性，机械强度，柔韧性，安全性，耐久性， 矫正视力，穿戴时的舒适度。