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公开(公告)号：US09664678B2
公开(公告)日：2017-05-30
申请号：US14238060
申请日：2012-09-03
CPC分类号： G01N33/54366 , G01N21/47 , G01N21/51 , G01N21/82 , G01N33/54313 , G01N35/025 , G01N2021/825 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2800/24
摘要： An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 μm to 0.43 μm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 μm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.
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公开(公告)号：US08858882B2
公开(公告)日：2014-10-14
申请号：US13577963
申请日：2011-02-24
CPC分类号： G01N21/51 , G01N21/532 , G01N35/025 , Y10T436/113332
摘要： There is provided a data processing method that reduces influences of air bubbles and dirt while maintaining changes in light amounts. Two scattering light photoreceivers are disposed in the forward direction. A photoreceiver 33a closer to the optical axis is taken to be a main angle photoreceiver, and a photoreceiver 33b further from the optical axis is taken to be a sub-angle photoreceiver. Noise is estimated based on the reaction process data of the sub-angle photoreceiver, and noise is reduced by subtracting the estimated noise from the reaction process data of the main angle photoreceiver.
摘要翻译： 提供了一种在保持光量变化的同时减少气泡和污物的影响的数据处理方法。 两个散射光接收器沿向前方向设置。 靠近光轴的光接收器33a被认为是主角光接收器，并且从光轴进一步的光接收器33b被认为是副角光接收器。 基于副角光接收器的反应过程数据估计噪声，并且通过从主角光接收器的反应过程数据中减去估计的噪声来降低噪声。
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公开(公告)号：US20140220705A1
公开(公告)日：2014-08-07
申请号：US14238060
申请日：2012-09-03
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N21/47 , G01N21/51 , G01N21/82 , G01N33/54313 , G01N35/025 , G01N2021/825 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2800/24
摘要： An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 μm to 0.43 μm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 μm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.
摘要翻译： 使用测量散射光的方法，分析仪提供适合于使用高灵敏度进行乳胶免疫测定的试剂的条件。 使用波长在0.65〜0.75μm范围内的照射光，从反应溶液产生的散射光以相对于照射方向为15°〜35°的受光角度被接受 反应容器 该试剂含有平均峰值粒径为0.3μm〜0.43μm的胶乳粒子，抗体被致敏。 反应溶液含有胶乳颗粒，其浓度为具有0.7μm波长的照射光的吸光度为0.25atm至1.10abs，以及由胶乳颗粒通过抗原凝集而引起的散射光量的变化 样品被测量和量化。
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公开(公告)号：US20120315190A1
公开(公告)日：2012-12-13
申请号：US13577963
申请日：2011-02-24
IPC分类号： G01N21/75
CPC分类号： G01N21/51 , G01N21/532 , G01N35/025 , Y10T436/113332
摘要： There is provided a data processing method that reduces influences of air bubbles and dirt while maintaining changes in light amounts. Two scattering light photoreceivers are disposed in the forward direction. A photoreceiver 33a closer to the optical axis is taken to be a main angle photoreceiver, and a photoreceiver 33b further from the optical axis is taken to be a sub-angle photoreceiver. Noise is estimated based on the reaction process data of the sub-angle photoreceiver, and noise is reduced by subtracting the estimated noise from the reaction process data of the main angle photoreceiver.
摘要翻译： 提供了一种在保持光量变化的同时减少气泡和污物的影响的数据处理方法。 两个散射光接收器沿向前方向设置。 靠近光轴的光接收器33a被认为是主角光接收器，并且从光轴进一步的光接收器33b被认为是副角光接收器。 基于副角光接收器的反应过程数据估计噪声，并且通过从主角光接收器的反应过程数据中减去估计的噪声来降低噪声。
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