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1.发明授权Transformed cell lines producing human monoclonal antibodies specific for Pseudomonas aeruginosa serotypes 失效产生对铜绿假单胞菌血清型特异性的人单克隆抗体的转化细胞系
公开(公告)号：US5521085A
公开(公告)日：1996-05-28
申请号：US41244
申请日：1993-04-01
申请人： Tamotsu Fukuda , Yasushi Ono , Shiro Shigeta , Yasuyuki Kuriowa , Hisayoshi Ooka
发明人： Tamotsu Fukuda , Yasushi Ono , Shiro Shigeta , Yasuyuki Kuriowa , Hisayoshi Ooka
CPC分类号： C07K16/1214 , C12N5/163 , A61K38/00
摘要： The present invention relates to human monoclonal antibodies capable of plurally binding with O-antigens of Pseudomonas aeruginosa, relates to novel parent cell lines for producing human hybridomas derived from human immunoglobulin synthesizing cells, which cell lines themselves incapable of producing human immunoglobulin and capable of fusing with human antibody-producing cells, relates to human-human hybridomas which can secrete monoclonal antibodies capable of binding with at least one of serotypes of Pseudomonas aeruginosa, relates to pharmaceutical compositions for prophylaxis or therapy of Pseudomonas aeruginosa infectious diseases, and relates to prophylactic or therapeutic methods for Pseudomonas aeruginosa infectious diseases.
摘要翻译： 本发明涉及能够多次与铜绿假单胞菌的O-抗原结合的人单克隆抗体，涉及用于产生源自人免疫球蛋白合成细胞的人杂交瘤的新型亲本细胞系，该细胞系本身不能产生人免疫球蛋白并能够融合 涉及可以分泌能够与铜绿假单胞菌的至少一种血清型结合的单克隆抗体的人 - 人杂交瘤，涉及用于预防或治疗铜绿假单胞菌感染性疾病的药物组合物，涉及预防或 铜绿假单胞菌感染性疾病的治疗方法。
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公开(公告)号：US4608827A
公开(公告)日：1986-09-02
申请号：US719552
申请日：1985-04-03
申请人： Mitsuru Hasegawa , Tamotsu Fukuda
发明人： Mitsuru Hasegawa , Tamotsu Fukuda
CPC分类号： F02C6/12 , F01P11/02 , F01P3/12 , F01P3/20 , F02B39/005 , F01P11/029 , F01P2060/12
摘要： A water jacket in the turbo-charger is positioned at the same level or higher than a water jacket in an engine cylinder head. The turbo-charger cooling water circulation passageway includes a water volume or tank positioned at a level higher than the turbo-charger cooling portion, and the volume or tank is connected to a cooling water reservoir tank via a pressure relief valve which is opened when pressure in the volume or tank exceeds a predetermined value to supply cooling water to the volume or tank.
摘要翻译： 涡轮增压器中的水套位于与发动机气缸盖中的水套相同的高度或更高的位置。 涡轮增压器冷却水循环通道包括位于高于涡轮增压器冷却部分的水位的水量或罐，并且容积或罐通过压力安全阀连接到冷却水储存罐，压力释放阀在压力 在容积或容器中超过预定值以将冷却水供应到容积或罐中。
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3.发明授权
公开(公告)号：US4579941A
公开(公告)日：1986-04-01
申请号：US407802
申请日：1982-08-13
CPC分类号： C07H21/00
摘要： Thermally-denatured DNA MD-011 having an antitumor activity was obtained by heating the substance separated from the disrupted cells of bacteria belonging to genus Mycobacterium.
摘要翻译： 通过加热从分枝杆菌属细菌的破碎细胞分离的物质获得具有抗肿瘤活性的热变性DNA MD-011。
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公开(公告)号：US4327685A
公开(公告)日：1982-05-04
申请号：US102899
申请日：1979-12-12
CPC分类号： F02M69/46 , F02M69/043 , F02M9/127
摘要： An intake system for internal combustion engines comprises a throttling system mounted in an intake pipe between a fuel injection valve and an intake manifold, the throttling system including a stationary valve body fixed in the intake pipe in opposed relation with the injection valve and a hollow valve body mounted in the intake pipe for movement in the axial direction of the intake pipe. The hollow valve body has a downwardly converged inner wall surface surrounding the stationary valve body to define therebetween valve opening of variable opening area. The stationary valve body includes a frusto-conical portion and a cylindrical portion, of which lower edge is in the form of sinusoidal wave to cooperate with the hollow valve body in producing the valve opening of gradually increasing opening area.
摘要翻译： 用于内燃机的进气系统包括安装在燃料喷射阀和进气歧管之间的进气管中的节流系统，所述节流系统包括固定在进气管中的与喷射阀相对的静止阀体和中空阀 主体安装在进气管中，用于沿进气管的轴向移动。 中空阀体具有围绕固定阀体的向下收敛的内壁表面，以在其间限定可变开口面积的阀开口。 固定阀体包括截头圆锥形部分和圆柱形部分，其下边缘为正弦波形状，以与中空阀体协作以产生逐渐增加的开口面积的阀门开口。
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公开(公告)号：US4173957A
公开(公告)日：1979-11-13
申请号：US802311
申请日：1977-06-01
CPC分类号： F02D41/1482 , Y02T10/42
摘要： An additional air supply system for adjusting the air-fuel ratio of a mixture includes the improved control unit for actuating, at two different speeds, a drive motor of a bypass valve disposed in an additional air supply path. The control unit is provided with an air-fuel ratio discriminating circuit for generating high and low level signals by comparing a detected air-fuel ratio with the stoichiometric ratio, and an actuating circuit for producing pulse signals at each instant of inversion of the signal levels of the air-fuel ratio discriminating circuit in such that for a predetermined period from the instant of inversion a high frequency pulse signal is produced and then a low frequency pulse signal is produced for the remaining period until the next inversion. Since the pusle signals having two different frequencies are applied to the drive motor of the bypass valve, the bypass valve is drived at a fast speed to a predetermined amount of opening or closing and then moved slowly until the next inversion of the signal level.
摘要翻译： 用于调节混合物的空燃比的另外的空气供应系统包括改进的控制单元，用于以两种不同的速度驱动设置在附加空气供应路径中的旁通阀的驱动马达。 控制单元设置有用于通过将检测到的空燃比与化学计量比进行比较来产生高电平和低电平信号的空燃比鉴别电路，以及用于在信号电平的每个反转时刻产生脉冲信号的致动电路 空燃比鉴别电路，在从反转时刻开始的规定期间，产生高频脉冲信号，然后产生低频脉冲信号，直至下一次反转为止。 由于具有两个不同频率的消息信号被施加到旁通阀的驱动电动机，旁通阀以快速的速度被驱动到预定的开启或关闭量，然后缓慢地移动直到信号电平的下一个反转。
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6.发明授权Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for protecting Pseudomonas aeruginosa infection 失效作为保护铜绿假单胞菌感染的药剂的铜绿假单胞菌的共同抗原（PSC-A）
公开(公告)号：US5114712A
公开(公告)日：1992-05-19
申请号：US586337
申请日：1990-09-17
申请人： Tamotsu Fukuda , Shiro Shigeta , Hiroaki Okuya , Yasuyuki Kuroiwa , Tadashi Sudo
发明人： Tamotsu Fukuda , Shiro Shigeta , Hiroaki Okuya , Yasuyuki Kuroiwa , Tadashi Sudo
CPC分类号： C07K14/21 , C07K16/1214 , A61K38/00 , A61K39/00 , Y10S530/825
摘要： PSC-A is a new serological common antigen to Pseudomonas aeruginosa having very low toxicity, and highly effective for protecting infection by any of the serotypes of Pseudomonas aeruginosa. PSC-A can be used as the active component in a pharmaceutical agent for protecting Pseudomonas aeruginosa infection.
摘要翻译： PSC-A是铜绿假单胞菌的新型血清学常见抗原，毒性非常低，对于保护铜绿假单胞菌血清型的感染非常有效。 PSC-A可用作用于保护铜绿假单胞菌感染的药剂中的活性成分。
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公开(公告)号：US4671240A
公开(公告)日：1987-06-09
申请号：US824109
申请日：1986-01-30
申请人： Kenzi Tanaka , Koichi Gomi , Tamotsu Fukuda , Masataka Hayashi
发明人： Kenzi Tanaka , Koichi Gomi , Tamotsu Fukuda , Masataka Hayashi
CPC分类号： F02M37/20 , F02M69/462 , F02M69/54 , F02D2250/02
摘要： A fuel injection type internal combustion engine provided with a pressure regulator for controlling a constant difference between a pressure of fuel supplied to the injector and a pressure of the intake system at the position where the injector is mounted. A tank is arranged for storing a positive pressure obtained while the engine is operated. A switching valve is arranged for connecting the tank with the pressure regulator when the engine is started when hot. Due to the operation of the regulator for maintaining the constant pressure difference, the pressure of the fuel supplied to the fuel injector is increased, making it difficult for the fuel to vaporize. Thus, preventing a so-called vapor lock.
摘要翻译： 一种燃料喷射型内燃机，其具有压力调节器，用于控制供给到喷射器的燃料的压力与进气系统在喷射器的安装位置的压力之间的恒定的差。 一个油箱布置用于储存在发动机运转时获得的正压力。 当发动机在热时起动时，设置有用于将油箱与压力调节器连接的切换阀。 由于用于维持恒定压力差的调节器的操作，供应到燃料喷射器的燃料的压力增加，使得燃料难以蒸发。 因此，防止所谓的蒸气锁。
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公开(公告)号：US4484881A
公开(公告)日：1984-11-27
申请号：US572051
申请日：1984-01-19
申请人： Akira Asari , Tamotsu Fukuda , Shiro Matsuura
发明人： Akira Asari , Tamotsu Fukuda , Shiro Matsuura
CPC分类号： B30B11/002 , B22F3/15 , B30B11/001
摘要： A hot isostatic pressing apparatus including a high pressure container having an opening at least at one end thereof for loading and unloading materials or products being formed. The high pressure container is internally provided with a heat insulator and a heater. A container holding frame has an open space substantially at the center thereof for releasably holding the upper and lower ends of the high pressure container during the hot isostatic pressing stage of the operation. The container holding frame is movably supported at one side thereof on a stationary structure for movements toward and away from the high pressure container.
摘要翻译： 一种热等静压装置，包括至少在其一端具有用于装载和卸载正在形成的材料或产品的开口的高压容器。 高压容器内部设有绝热器和加热器。 容器保持框架具有大致在其中心的开放空间，用于在操作的热等静压阶段期间可释放地保持高压容器的上端和下端。 容器保持框架在其一侧可移动地支撑在固定结构上以朝向和远离高压容器移动。
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公开(公告)号：US4419972A
公开(公告)日：1983-12-13
申请号：US75683
申请日：1979-09-13
CPC分类号： F02M9/1275
摘要： An intake system for an internal combustion engine comprises a throttling system mounted in an intake pipe between a fuel injection valve and an intake manifold, the throttling system including a stationary valve body fixed in the intake pipe in opposition to the injection valve and a hollow valve body mounted in the intake pipe movably in an axial direction of the intake pipe. The hollow valve body has a downwardly converged inner wall surface surrounding the stationary valve body to define therebetween valve opening of variable opening area. The axial movement of the hollow valve body causes the change in the opening area of the valve opening to control an amount of air-fuel mixture charged therethrough into the engine.
摘要翻译： 一种用于内燃机的进气系统包括安装在燃料喷射阀和进气歧管之间的进气管中的节流系统，所述节流系统包括固定在进气管中的与喷射阀相对的静止阀体和中空阀 主体安装在进气管中，沿进气管的轴向可移动。 中空阀体具有围绕固定阀体的向下收敛的内壁表面，以在其间限定可变开口面积的阀开口。 中空阀体的轴向运动导致阀开口的开口面积的变化来控制通过其进入发动机的空气燃料混合物的量。
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公开(公告)号：US4285319A
公开(公告)日：1981-08-25
申请号：US91755
申请日：1979-11-06
CPC分类号： F02D41/1481 , F02B1/04
摘要： An air flow amount adjusting system produces an air-fuel mixture of a desirable air-fuel ratio by controlling the direction of movement of a bypass valve mounted in an additional air supply pipe adapted to supply additional air into either the intake system or exhaust system of an internal combustion engine in accordance with an output signal produced from a gas sensor mounted in the exhaust system of the engine and indicative of the air-fuel ratio of the mixture supplied to the engine. A two-level mode signal whose threshold corresponds to the desired air-fuel ratio is produced in accordance with the output signal of the gas detector. After the two-level mode signal has changed from one level to the other level, the movement of the bypass valve is stopped for a certain period of time. If desired, the stopping period of the bypass valve may be changed in accordance with the temperature of the engine.
摘要翻译： 空气流量调节系统通过控制安装在附加空气供应管中的旁通阀的运动方向来产生期望空燃比的空气 - 燃料混合物，该附加空气供应管适于将额外空气供应到进气系统或排气系统 根据从安装在发动机的排气系统中的气体传感器产生的输出信号的内燃机，其指示供应给发动机的混合物的空燃比。 根据气体检测器的输出信号产生阈值对应于所需空燃比的两电平模式信号。 在双电平模式信号从一个电平变化到另一个电平之后，旁路阀的运动停止一段时间。 如果需要，可以根据发动机的温度来改变旁通阀的停止时段。
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