公开(公告)号：US09726669B2

公开(公告)日：2017-08-08

申请号：US12854144

申请日：2010-08-10

申请人： Phillip Kim ,  Xinjun Liu ,  Richard Kirkland ,  Tani Lee ,  Belen Ybarrondo ,  Sharat Singh

发明人： Phillip Kim ,  Xinjun Liu ,  Richard Kirkland ,  Tani Lee ,  Belen Ybarrondo ,  Sharat Singh

IPC分类号： G01N33/574 ,  G01N33/50

CPC分类号： G01N33/57415 ,  G01N33/5011 ,  G01N2800/52

摘要： The present invention provides compositions and methods for detecting the expression and/or activation states of components of signal transduction pathways in cells such as tumor cells. Information on the expression and/or activation states of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

公开(公告)号：US09488654B2

公开(公告)日：2016-11-08

申请号：US13545947

申请日：2012-07-10

申请人： Xinjun Liu ,  Phillip Kim ,  Richard Kirkland ,  Tani Lee ,  Belen Ybarrondo ,  Sharat Singh

发明人： Xinjun Liu ,  Phillip Kim ,  Richard Kirkland ,  Tani Lee ,  Belen Ybarrondo ,  Sharat Singh

IPC分类号： G01N33/574

CPC分类号： G01N33/57415 ,  G01N2333/71 ,  G01N2800/52

摘要： The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative metastatic breast tumor cells. Information on the expression and/or activation levels of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

摘要翻译： 本发明提供用于检测肿瘤细胞如三阴性转移性乳腺肿瘤细胞中的信号转导途径的组分的表达和/或活化水平的组合物和方法。 关于衍生自本发明的信号转导途径的组分的表达和/或活化水平的信息可用于癌症诊断，预后和癌症治疗的设计。

公开(公告)号：US20130012407A1

公开(公告)日：2013-01-10

申请号：US13545947

申请日：2012-07-10

申请人： Xinjun Liu ,  Phillip Kim ,  Richard Kirkland ,  Tani Lee ,  Belen Ybarrondo ,  Sharat Singh

发明人： Xinjun Liu ,  Phillip Kim ,  Richard Kirkland ,  Tani Lee ,  Belen Ybarrondo ,  Sharat Singh

IPC分类号： C40B30/04

CPC分类号： G01N33/57415 ,  G01N2333/71 ,  G01N2800/52

摘要： The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative metastatic breast tumor cells. Information on the expression and/or activation levels of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

摘要翻译： 本发明提供用于检测肿瘤细胞如三阴性转移性乳腺肿瘤细胞中的信号转导途径的组分的表达和/或活化水平的组合物和方法。 关于衍生自本发明的信号转导途径的组分的表达和/或活化水平的信息可用于癌症诊断，预后和癌症治疗的设计。

公开(公告)号：US20110071042A1

公开(公告)日：2011-03-24

申请号：US12854144

申请日：2010-08-10

申请人： Phillip Kim ,  Xinjun Liu ,  Richard Kirkland ,  Tani Lee ,  Belen Ybarrondo ,  Sharat Singh

发明人： Phillip Kim ,  Xinjun Liu ,  Richard Kirkland ,  Tani Lee ,  Belen Ybarrondo ,  Sharat Singh

IPC分类号： C40B30/04 ,  G01N33/566

CPC分类号： G01N33/57415 ,  G01N33/5011 ,  G01N2800/52

摘要： The present invention provides compositions and methods for detecting the expression and/or activation states of components of signal transduction pathways in cells such as tumor cells. Information on the expression and/or activation states of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

摘要翻译： 本发明提供用于检测诸如肿瘤细胞的细胞中信号转导途径的组分的表达和/或激活状态的组合物和方法。 关于衍生自本发明的信号转导途径的组分的表达和/或激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。