公开(公告)号：US09617538B2

公开(公告)日：2017-04-11

申请号：US14241580

申请日：2012-08-24

申请人： Masayuki Nashimoto ,  Masuhiro Takahashi ,  Miwako Narita ,  Tetsuo Yoshida ,  Tatsuya Miyazawa

发明人： Masayuki Nashimoto ,  Masuhiro Takahashi ,  Miwako Narita ,  Tetsuo Yoshida ,  Tatsuya Miyazawa

IPC分类号： C07H21/02 ,  C12N15/113 ,  A61K31/7105

CPC分类号： C12N15/113 ,  A61K31/7105 ,  C12N2310/12

摘要： There is provided a heptamer-type small guide nucleic acid that comprises any of the 7-base sequences of SEQ ID NOS: 1 to 15, and induces apoptosis of human leukemia cells. A leukemia therapeutic agent containing the heptamer-type small guide nucleic acid as an active ingredient is also provided. The novel heptamer-type sg nucleic acid can induce apoptosis of human leukemia cells.

公开(公告)号：US20100099746A1

公开(公告)日：2010-04-22

申请号：US12519960

申请日：2007-12-18

申请人： Yoji Yamada ,  Tatsuya Miyazawa ,  Tetsuo Yoshida ,  Haruo Nakano ,  Kyoko Kosaka

发明人： Yoji Yamada ,  Tatsuya Miyazawa ,  Tetsuo Yoshida ,  Haruo Nakano ,  Kyoko Kosaka

IPC分类号： A61K31/7088 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68 ,  A61P35/00

CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2330/10

摘要： The present invention provides a nucleic acid such as a micro-RNA or a micro-RNA precursor, having a novel sequence. The nucleic acid of the present invention is useful for detecting the expression or a mutation of a micro-RNA, separating cells, suppressing the expression of a gene having a target sequence, screening for a substance that promotes or suppresses a function of a micro-RNA, and diagnosing or treating a disease caused by a mast cell abnormality, a disease caused by an abnormality of mesenchymal stem cell proliferation or differentiation, cancers, and a disease caused by abnormal proliferation of cells, tissue hyperplasia or the like.

摘要翻译： 本发明提供具有新序列的核酸如微RNA或微RNA前体。 本发明的核酸可用于检测微RNA的表达或突变，分离细胞，抑制具有靶序列的基因的表达，筛选促进或抑制微小RNA功能的物质， RNA，诊断或治疗由肥大细胞异常引起的疾病，由间充质干细胞增殖或分化异常引起的疾病，癌症和由细胞异常增殖，组织增生等引起的疾病。

公开(公告)号：US20150025232A1

公开(公告)日：2015-01-22

申请号：US14241580

申请日：2012-08-24

申请人： Masayuki Nashimoto ,  Masuhiro Takahashi ,  Miwako Narita ,  Tetsuo Yoshida ,  Tatsuya Miyazawa

发明人： Masayuki Nashimoto ,  Masuhiro Takahashi ,  Miwako Narita ,  Tetsuo Yoshida ,  Tatsuya Miyazawa

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  A61K31/7105 ,  C12N2310/12

摘要： There is provided a heptamer-type small guide nucleic acid that comprises any of the 7-base sequences of SEQ ID NOS: 1 to 15, and induces apoptosis of human leukemia cells. A leukemia therapeutic agent containing the heptamer-type small guide nucleic acid as an active ingredient is also provided. The novel heptamer-type sg nucleic acid can induce apoptosis of human leukemia cells.

摘要翻译： 提供了包含SEQ ID NO：1至15的任何7-碱基序列的七聚体型小导向核酸，并诱导人白血病细胞的凋亡。 还提供含有七聚体型小引导核酸作为有效成分的白血病治疗剂。 新型七聚体型sg核酸可诱导人白血病细胞凋亡。

公开(公告)号：US20110130442A1

公开(公告)日：2011-06-02

申请号：US12996082

申请日：2009-06-04

申请人： Kyoko Kosaka ,  Yoji Yamada ,  Kazumi Miura ,  Tatsuya Miyazawa ,  Tetsuo Yoshida

发明人： Kyoko Kosaka ,  Yoji Yamada ,  Kazumi Miura ,  Tatsuya Miyazawa ,  Tetsuo Yoshida

IPC分类号： A61K31/7088 ,  C07H21/04 ,  C12N15/63 ,  C07H21/02 ,  A61P17/00 ,  A61P11/06 ,  A61P37/08 ,  C12N5/00 ,  C40B30/06

CPC分类号： A61K31/713 ,  C12N15/113 ,  C12N2310/141 ,  C12N2330/10

摘要： Provided are a mast cell degranulation control agent, a diagnostic agent or therapeutic agent for a disease resulting from mast cell degranulation control, a method of controlling mast cell degranulation, and a screening method for a mast cell degranulation control agent, all of which involve the use of a nucleic acid and the like. These are useful in the diagnosis or treatment of a disease resulting from mast cell degranulation control.

摘要翻译： 提供了肥大细胞脱粒控制剂，用于由肥大细胞脱粒控制引起的疾病的诊断剂或治疗剂，控制肥大细胞脱粒的方法和肥大细胞脱粒控制剂的筛选方法，所有这些都涉及 使用核酸等。 这些可用于诊断或治疗由肥大细胞脱粒控制引起的疾病。

公开(公告)号：US20110021600A1

公开(公告)日：2011-01-27

申请号：US12439945

申请日：2007-09-04

申请人： Yoji Yamada ,  Tatsuya Miyazawa ,  Tetsuo Yoshida ,  Haruo Nakano ,  Kyoko Kosaka

发明人： Yoji Yamada ,  Tatsuya Miyazawa ,  Tetsuo Yoshida ,  Haruo Nakano ,  Kyoko Kosaka

IPC分类号： A61K31/7088 ,  C07H21/02 ,  C12N15/63 ,  C12Q1/68 ,  C12N5/10

CPC分类号： A61K31/7088 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/141

摘要： According to the present invention, it possible to provide a novel nucleic acid, a vector that expresses the nucleic acid, a screening method for a substance that controls the nucleic acid, a method of detecting the expression and a mutation of the nucleic acid, and a diagnostic method or therapeutic method for a disease caused by an abnormality of mesenchymal stem cells, mast cells or the like, or a disease caused by a cell proliferation abnormality, such as cancer.

摘要翻译： 根据本发明，可以提供新的核酸，表达核酸的载体，控制核酸的物质的筛选方法，检测核酸的表达和突变的方法，以及 由间充质干细胞，肥大细胞等的异常引起的疾病的诊断方法或治疗方法，或由细胞增殖异常引起的疾病，例如癌症。

公开(公告)号：US20100305188A1

公开(公告)日：2010-12-02

申请号：US12681417

申请日：2008-10-03

申请人： Haruo Nakano ,  Tatsuya Miyazawa ,  Yoji Yamada ,  Tetsuo Yoshida

发明人： Haruo Nakano ,  Tatsuya Miyazawa ,  Yoji Yamada ,  Tetsuo Yoshida

IPC分类号： A61K31/7105 ,  A61K31/7088 ,  C12Q1/68 ,  A61P35/00

CPC分类号： A61K31/7088 ,  C12N15/113 ,  C12N2310/141 ,  C12N2330/10

摘要： Provided are an agent for suppressing or promoting cell proliferation, a diagnostic reagent or therapeutic drug for a disease resulting from a cell proliferation abnormality, an agent for inducing apoptosis, an agent for suppressing or promoting the expression of a target gene for a nucleic acid such as a microRNA, and a method of suppressing or promoting cell proliferation.

摘要翻译： 提供抑制或促进细胞增殖的药剂，用于由细胞增殖异常引起的疾病的诊断试剂或治疗药物，诱导细胞凋亡的药剂，抑制或促进核酸靶基因表达的试剂，例如 作为微小RNA，以及抑制或促进细胞增殖的方法。