公开(公告)号：US20230289959A1

公开(公告)日：2023-09-14

申请号：US18040008

申请日：2021-07-30

申请人： Tatsuya Niimi ,  Takashi Matsumura ,  Takuya Saito

发明人： Tatsuya Niimi ,  Takashi Matsumura ,  Takuya Saito

IPC分类号： G06T7/00 ,  G16H30/40

CPC分类号： G06T7/0012 ,  G16H30/40 ,  G06T2207/10088

摘要： A three-dimensional object can be produced based on biological property information indicating a biological property obtained by MRE measurement of an organism. The three-dimensional object has a distribution of a strength property corresponding to a distribution of the biological property.

公开(公告)号：US10854113B2

公开(公告)日：2020-12-01

申请号：US15450720

申请日：2017-03-06

申请人： Yoshihiro Norikane ,  Tatsuya Niimi ,  Takashi Matsumura ,  Hiroshi Iwata ,  Hiroyuki Naito

发明人： Yoshihiro Norikane ,  Tatsuya Niimi ,  Takashi Matsumura ,  Hiroshi Iwata ,  Hiroyuki Naito

IPC分类号： G09B23/30 ,  B29C64/20 ,  B33Y70/00 ,  B29C64/112 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y80/00 ,  B29L31/00 ,  B29K105/00 ,  B29L31/40

摘要： A solid freeform fabrication object includes a hydrogel including a polymer, water, and a coloring material inclusion substance.

公开(公告)号：US10442181B2

公开(公告)日：2019-10-15

申请号：US15209268

申请日：2016-07-13

申请人： Hiroshi Iwata ,  Tatsuya Niimi ,  Yoshihiro Norikane ,  Takashi Matsumura

发明人： Hiroshi Iwata ,  Tatsuya Niimi ,  Yoshihiro Norikane ,  Takashi Matsumura

IPC分类号： B33Y70/00 ,  B29C64/112 ,  C08K5/053 ,  C08K5/05 ,  B29C64/40 ,  B33Y10/00 ,  B29L31/00

摘要： A hydrogel object includes a polymer and water, wherein the rate of mass loss is not greater than 20 percent by mass when the hydrogel object is left undone for one week at 25 degrees C. and relative humidity of 50 percent.

公开(公告)号：US20170022348A1

公开(公告)日：2017-01-26

申请号：US15209268

申请日：2016-07-13

申请人： Hiroshi IWATA ,  Tatsuya NIIMI ,  Yoshihiro NORIKANE ,  Takashi MATSUMURA

发明人： Hiroshi IWATA ,  Tatsuya NIIMI ,  Yoshihiro NORIKANE ,  Takashi MATSUMURA

IPC分类号： C08K5/053 ,  B33Y70/00 ,  C08J5/18 ,  B29C67/00 ,  C08K3/34 ,  C08J5/00

CPC分类号： B33Y70/00 ,  B29C64/112 ,  B29C64/40 ,  B29L2031/7532 ,  B33Y10/00 ,  C08K5/05 ,  C08K5/053 ,  C08L33/26 ,  C08K3/346

摘要： A hydrogel object includes a polymer and water, wherein the rate of mass loss is not greater than 20 percent by mass when the hydrogel object is left undone for one week at 25 degrees C. and relative humidity of 50 percent.

摘要翻译： 水凝胶体包含聚合物和水，其中，当水凝胶体在25℃，相对湿度为50％下放置一周时，其质量损失率不大于20质量％。

公开(公告)号：US20110111335A1

公开(公告)日：2011-05-12

申请号：US12940854

申请日：2010-11-05

申请人： Keisuke SHIMOYAMA ,  Eiji Kurimoto ,  Takeshi Orito ,  Tatsuya Niimi ,  Shinichi Kawamura ,  Yoshiki Yanagawa ,  Michitaka Sasaki

发明人： Keisuke SHIMOYAMA ,  Eiji Kurimoto ,  Takeshi Orito ,  Tatsuya Niimi ,  Shinichi Kawamura ,  Yoshiki Yanagawa ,  Michitaka Sasaki

IPC分类号： G03G5/04

CPC分类号： G03G5/0651 ,  G03G5/0614 ,  G03G5/0696 ,  G03G5/071 ,  G03G5/144 ,  G03G5/14704 ,  G03G5/14734 ,  G03G5/14786 ,  G03G5/14791

摘要： To provide an electrophotographic photoconductor that has a layer containing a compound represented by the following general formula (1), and an image forming apparatus using the electrophotographic photoconductor. where R1 and R2 independently represent any one of a hydrogen atom, substituted or unsubstituted alkyl group, substituted or unsubstituted cycloalkyl group and substituted or unsubstituted aralkyl group, and R3, R4, R5, R6, R7, R8, R9 and R10 independently represent any one of a hydrogen atom, halogen atom, cyano group, nitro group, amino group, hydroxyl group, substituted or unsubstituted alkyl group, substituted or unsubstituted cycloalkyl group and substituted or unsubstituted aralkyl group

摘要翻译： 提供具有含有由以下通式（1）表示的化合物的层的电子照相感光体和使用电子照相感光体的图像形成装置。 其中R 1和R 2独立地表示氢原子，取代或未取代的烷基，取代或未取代的环烷基和取代或未取代的芳烷基中的任一个，R 3，R 4，R 5，R 6，R 7，R 8，R 9和R 10独立地表示任何 氢原子，卤原子，氰基，硝基，氨基，羟基，取代或未取代的烷基，取代或未取代的环烷基和取代或未取代的芳烷基

公开(公告)号：US20110071146A1

公开(公告)日：2011-03-24

申请号：US12943435

申请日：2010-11-10

申请人： Tatsuya Niimi ,  Akio Kamikawa ,  Yasushi Amano ,  Tomohiko Yamaguchi ,  Kenichi Suzumura ,  Kentaro Enjo ,  Takashi Furutani ,  Akio Kakefuda ,  Yutaka Kondoh ,  Masaaki Hirano

发明人： Tatsuya Niimi ,  Akio Kamikawa ,  Yasushi Amano ,  Tomohiko Yamaguchi ,  Kenichi Suzumura ,  Kentaro Enjo ,  Takashi Furutani ,  Akio Kakefuda ,  Yutaka Kondoh ,  Masaaki Hirano

IPC分类号： A61K31/536 ,  A61K31/40 ,  A61K31/415 ,  A61K31/44 ,  A61K31/41 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/42 ,  A61P13/08

CPC分类号： C07D209/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D513/04

摘要： To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17βHSD type 5.It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17βHSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

摘要翻译： 提供治疗和/或预防前列腺癌，良性前列腺增生，痤疮，皮脂溢，多毛症，秃发，脱发，早熟青春期，肾上腺肥大，多囊卵巢综合征，乳腺癌，肺癌，子宫内膜异位症，平滑肌瘤和 基于针对17＆amp; HSD型5的选择性抑制活性的类似物。已经发现，吲哚环被羧基取代的N-磺基吲哚衍生物，羧基取代的低级烷基或羧基取代的低级烯基 在其碳原子上具有对17和HSD 5型的有效的选择性抑制活性，并且可能成为由于睾丸激素降低引起的伴有不良药物反应的良性前列腺增生，前列腺癌等的治疗剂和/或预防剂， 从而完成了本发明。

公开(公告)号：US07855225B2

公开(公告)日：2010-12-21

申请号：US12281416

申请日：2007-03-01

申请人： Tatsuya Niimi ,  Akio Kamikawa ,  Yasushi Amano ,  Tomohiko Yamaguchi ,  Kenichi Suzumura ,  Kentaro Enjo ,  Takashi Furutani ,  Akio Kakefuda ,  Yutaka Kondoh ,  Masaaki Hirano

发明人： Tatsuya Niimi ,  Akio Kamikawa ,  Yasushi Amano ,  Tomohiko Yamaguchi ,  Kenichi Suzumura ,  Kentaro Enjo ,  Takashi Furutani ,  Akio Kakefuda ,  Yutaka Kondoh ,  Masaaki Hirano

IPC分类号： C07D209/42 ,  A61K31/404

CPC分类号： C07D209/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D513/04

摘要： To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17βHSD type 5.It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17βHSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

摘要翻译： 提供治疗和/或预防前列腺癌，良性前列腺增生，痤疮，皮脂溢，多毛症，秃发，脱发，早熟性青春期，肾上腺肥大，多囊卵巢综合征，乳腺癌，肺癌，子宫内膜异位症，平滑肌瘤和 基于针对17＆amp; HSD型5的选择性抑制活性的类似物。已经发现，吲哚环被羧基取代的N-磺基吲哚衍生物，羧基取代的低级烷基或羧基取代的低级烯基 在其碳原子上具有对17和HSD 5型的有效的选择性抑制活性，并且可能成为由于睾丸激素降低引起的伴有不良药物反应的良性前列腺增生，前列腺癌等的治疗剂和/或预防剂， 从而完成了本发明。

公开(公告)号：US20100310975A1

公开(公告)日：2010-12-09

申请号：US12792303

申请日：2010-06-02

申请人： Hiromi Tada ,  Masafumi Ohta ,  Tatsuya Niimi ,  Norio Nagayama ,  Yoshiki Yanagawa ,  Yuuji Tanaka

发明人： Hiromi Tada ,  Masafumi Ohta ,  Tatsuya Niimi ,  Norio Nagayama ,  Yoshiki Yanagawa ,  Yuuji Tanaka

IPC分类号： G03G15/00 ,  G03G21/16 ,  G03G5/04

CPC分类号： G03G5/05 ,  G03G5/0675 ,  G03G5/0696

摘要： An electrophotographic photoreceptor, including an electroconductive substrate; and a photosensitive layer overlying the substrate, wherein the photosensitive layer comprises a complex azo pigment comprising an azo compound having the following formula (a): A(H)n  (a) wherein A represents a residue of an azo compound, bonded with n pieces of hydrogen atom through one or more heteroatom being N or O and forming a part of the residue A; H represents a hydrogen atom; and n represents an integer of from 1 to 9, and a pigment.

摘要翻译： 电子照相感光体，包括导电性基材; 以及覆盖所述基板的感光层，其中所述感光层包含复合偶氮颜料，其包含具有下式（a）的偶氮化合物：A（H）n（a）其中A表示与n键合的偶氮化合物的残基 通过一个或多个杂原子的氢原子是N或O并形成残基A的一部分; H表示氢原子; 和n表示1〜9的整数，和颜料。

公开(公告)号：US07846635B2

公开(公告)日：2010-12-07

申请号：US11669957

申请日：2007-02-01

申请人： Tatsuya Niimi

发明人： Tatsuya Niimi

IPC分类号： G03G5/087 ,  G03G15/00

CPC分类号： G03G5/14704 ,  G03G5/14765 ,  G03G5/14791 ,  G03G5/14795 ,  G03G15/751

摘要： An image forming apparatus including an image bearing member for bearing a latent electrostatic image including a substrate, an intermediate layer containing a metal oxide and a photosensitive layer containing a charge transport layer and a charge generating layer containing an organic charge generating material, a charging device for charging the image bearing member, a writing device for writing the latent electrostatic image on the image bearing member by irradiating the image bearing member with light having a wavelength shorter than 450 nm which the metal oxide absorbs so that carriers can be generated, a developing device for developing the latent electrostatic image with a toner to form a visualized image, a transfer device for transferring the visualized image to a recording medium, a fixing device for fixing the transferred image on the recording image, and a discharging device for optically discharging residual charges on the image bearing member.

摘要翻译： 一种图像形成装置，包括用于承载包括基底的静电潜像的图像承载构件，含有金属氧化物的中间层和含有电荷输送层的感光层和含有有机电荷产生材料的电荷产生层， 用于对图像承载部件充电的写入装置，用于通过用金属氧化物吸收的波长短于450nm的光照射图像承载部件来使静电潜像图像写入到图像承载部件上，从而能够产生载流子; 用调色剂显影静电潜像以形成可视化图像的装置，用于将可视图像转印到记录介质的转印装置，用于将转印图像定影在记录图像上的定影装置，以及用于光学地放出残留物的放电装置 图像承载部件上的电荷。

公开(公告)号：US07796902B2

公开(公告)日：2010-09-14

申请号：US12382506

申请日：2009-03-18

申请人： Naoto Watanabe ,  Tatsuya Niimi ,  Hitoshi Ishibashi

发明人： Naoto Watanabe ,  Tatsuya Niimi ,  Hitoshi Ishibashi

IPC分类号： G03G15/00

CPC分类号： G03G15/5037

摘要： An image forming apparatus includes a charge unit, an exposure unit, an exposure voltage detector, a development unit, and a concentration detector. The exposure voltage detector detects a potential of latent image formed as a test pattern on an image carrier. The concentration detector detects concentration of developed test pattern. The image forming apparatus further includes an exposure power controller, an exposure ratio controller, a charging voltage controller, a development bias voltage controller, and an image forming condition adjustment controller. A suitable image forming condition is computed using test patterns formed by changing combinations of charging voltage, exposure power, and exposure duty. The charging voltage is changed in two levels or more. The exposure power is changed in three levels or more. The exposure duty per unit area is changed in two levels or more.

摘要翻译： 图像形成装置包括充电单元，曝光单元，曝光电压检测器，显影单元和浓度检测器。 曝光电压检测器检测在图像载体上形成为测试图案的潜像的电位。 浓度检测器检测显影测试图案的浓度。 图像形成装置还包括曝光功率控制器，曝光比率控制器，充电电压控制器，显影偏压控制器和图像形成条件调节控制器。 使用通过改变充电电压，曝光功率和曝光占空比的组合形成的测试图案来计算合适的图像形成条件。 充电电压在两个等级以上更改。 曝光功率在三个等级以上更改。 每单位面积的曝光负荷在两个等级以上更改。