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    Pyrrole derivatives
    2.
    发明授权
    Pyrrole derivatives 失效
    吡咯衍生物

    公开(公告)号：US06759429B2

    公开(公告)日：2004-07-06

    申请号：US10352067

    申请日：2003-01-28

    申请人： Teruhisa Tokunaga ,  William Ewan Hume ,  Makoto Kitoh ,  Ryu Nagata

    发明人： Teruhisa Tokunaga ,  William Ewan Hume ,  Makoto Kitoh ,  Ryu Nagata

    IPC分类号： A61K304015

    CPC分类号： C07D207/33 ,  C07D207/333 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04

    摘要： Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, an optionally substituted C1-C4 alkylene, etc.; Ar2 is an optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2): (1) W1 is an optionally substituted C1-C4 alkylene, etc.; Ar1 is an optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is an optionally substituted C2-C5 alkylene, an optionally substituted C2-C5 alkenylene, etc.; and Ar1 is an aryl or monocyclic heteroaryl, which are substituted by carboxyl, an alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof. These compounds are useful as medicaments such as a fibrosis inhibitor for organs or tissues.

    摘要翻译： 由下式表示的吡咯衍生物：其中环Z是任选取代的吡咯环等; W 2是-CO - ， - SO 2 - ，任选取代的C 1 -C 4亚烷基等; Ar 2是任选取代的芳基等; W 1和Ar 1表示以下（1）和（2）：（1）W 1是任选取代的C 1 -C 4亚烷基等; Ar 1是具有1-4个氮原子的任选取代的双环杂芳基作为成环原子：（2）W 1是任选取代的C 2 -C 5亚烷基，任选取代的C 2 -C 5亚烯基等; 并且Ar 1是在相对于W 1的结合位置的邻位或间位被羧基，烷氧基羰基等取代的芳基或单环杂芳基，或其药学上可接受的盐 。 这些化合物可用作药物如用于器官或组织的纤维化抑制剂。

    OXINDOLE DERIVATIVE AS FEEDING CONTROL AGENT
    4.
    发明申请
    OXINDOLE DERIVATIVE AS FEEDING CONTROL AGENT 失效
    氧化物衍生物作为饲料控制剂

    公开(公告)号：US20090131398A1

    公开(公告)日：2009-05-21

    申请号：US12066251

    申请日：2006-09-13

    申请人： Teruhisa Tokunaga ,  Tsuyoshi Takasaki ,  Kozo Yoshida ,  Ryu Nagata

    发明人： Teruhisa Tokunaga ,  Tsuyoshi Takasaki ,  Kozo Yoshida ,  Ryu Nagata

    IPC分类号： A61K31/404 ,  C07D209/38 ,  A61P3/10 ,  C07D403/06

    CPC分类号： C07D403/06 ,  C07D209/34 ,  C07D209/38 ,  C07D405/04 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04

    摘要： Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent for diabetes and the like. (In the formula, R3 represents an optionally substituted carbamoyl group or the like; X represents a hydroxyl group or the like; W1 and W2 independently represent a single bond or methylene; R7 and R8 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; and Ar represents an optionally substituted aryl group or the like.)

    摘要翻译： 公开了由下式（1）表示的化合物，其前药或其药学上可接受的盐，其可用作糖尿病等的治疗性预防或改善剂。 （式中，R 3表示可以具有取代基的氨基甲酰基等，X表示羟基等; W 1和W 2分别表示单键或亚甲基，R 7，R 8分别表示氢原子，可以具有取代基的烷基 或类似物; Ar表示任选取代的芳基等）。

    Oxindole derivative
    5.
    发明授权
    Oxindole derivative 失效
    羟吲哚衍生物

    公开(公告)号：US06576656B1

    公开(公告)日：2003-06-10

    申请号：US09763241

    申请日：2001-03-22

    申请人： Teruhisa Tokunaga ,  Takashi Umezome ,  W. Ewan Hume ,  Ryu Nagata ,  Kazuhiko Okazaki ,  Yasuyuki Ueki ,  Kazuo Kumagai

    发明人： Teruhisa Tokunaga ,  Takashi Umezome ,  W. Ewan Hume ,  Ryu Nagata ,  Kazuhiko Okazaki ,  Yasuyuki Ueki ,  Kazuo Kumagai

    IPC分类号： A61K3140

    CPC分类号： C07D401/04 ,  C07D209/38 ,  C07D209/40 ,  C07D403/06 ,  C07D405/04 ,  C07D409/04 ,  C07D413/06 ,  C07D417/04

    摘要： An oxindole of Formula 1 or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser: wherein R1, R2, R3 and R4 are independently hydrogen, optionally substituted alkyl etc; R5 is optionally substituted aryl or optionally substituted heteroaryl; Z is —O— or —NH—; one of W1 and W2 is hydrogen, alkyl or —Y—CON(R10)R11; the other of W1 and W2 is n is 1, 2 or 3; m is 0, 1, 2 or 3; Y is single bond or C1-C3 alkylene; R6 and R7 are independently hydrogen, optionally substituted alkyl etc; R8 and R9 are independently hydrogen, optionally substituted alkyl etc; R10 and R11 are independently hydrogen, alkyl etc.

    摘要翻译： 式1的羟吲哚或其前药或其药学上可接受的盐可用于生长激素释放剂：其中R 1，R 2，R 3和R 4独立地为氢，任选取代的烷基等; R 5为任选取代的芳基或任选取代的杂芳基; Z 是-O-或-NH-; W1和W2之一是氢，烷基或-Y-CON（R10）R11; W1和W2中的另一个是1,2或3; m是0,1,2或3; Y是单键或C1-C3亚烷基; R6和R7独立地是氢，任选取代的烷基等; R 8和R 9独立地是氢，任选取代的烷基等; R 10和R 11独立地是氢 ，烷基等