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14 条记录 (耗时 0.042 秒)

    Pyrrolopyridazinone Compound
    2.
    发明申请
    Pyrrolopyridazinone Compound 失效

    公开(公告)号：US20090036453A1

    公开(公告)日：2009-02-05

    申请号：US12087864

    申请日：2007-01-16

    申请人： Masahiko Hagihara ,  Masayuki Tanaka ,  Tetsushi Katsube ,  Makoto Okudo ,  Noriaki Iwase ,  Manabu Shigetomi ,  Tomoko Kanda ,  Takayuki Nakanishi

    发明人： Masahiko Hagihara ,  Masayuki Tanaka ,  Tetsushi Katsube ,  Makoto Okudo ,  Noriaki Iwase ,  Manabu Shigetomi ,  Tomoko Kanda ,  Takayuki Nakanishi

    IPC分类号： A61K31/5025 ,  C07D487/02 ,  A61P11/00 ,  A61P9/00 ,  A61P37/00

    CPC分类号： C07D487/04

    摘要： The present invention discloses a pyrrolopyridazinone compound represented by the formula (1): wherein R1 represents C1-C2 alkyl group or halogeno C1-C2 alkyl group, R2 repersents C3-C5 cycloalkyl group, (C3-C5 cycloalkyl)C1-C2 alkyl group or C1-C3 alkyl group, R3 represents hydrogen atom, or methylene group or cis-vinylene group for forming substituted oxygen-containing hetero ring in combination with group —O—R2, R4 represents hydrogen atom, halogen atom, C1-C8 alkyl group, C2-C6 alkenyl group, C2-C6 alkynyl group, hydroxy C3-C6 alkenyl group, hydroxy C3-C6 alkynyl group, C1-C6 alkyl group substituted by substituent(s) selected from Substituent group (a), C3-C6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), “C1-C3 alkyl group which is substituted by C3-C6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), and which may be substituted by a hydroxy group”, an aromatic ring group or heteroaromatic ring group each of which may be substituted by a substituent(s) selected from Substituent group (c) or “C1-C2 alkyl group which is substituted by aromatic ring group or heteroaromatic ring group each of which may be substituted by group(s) selected from Substituent group (c), and which may be substituted by a hydroxy group”, Substituent group (a) represents a halogen atom, hydroxy group, cyano group, carboxy group, C1-C5 alkoxy group, halogeno C1-C4 alkoxy group, C3-C6 cycloalkoxy group, (C3-C6 cycloalkyl)C1-C2 alkoxy group, C1-C4 alkoxycarbonyl group, C2-C4 alkanoyl group, C2-C4 alkanoyloxy group or C1-C4 alkyl-substituted amino group, Substituent group (b) represents a hydroxy group or a halogen atom, Substituent group (c) represents a halogen atom, a hydroxy group, a cyano group, a nitro group, a carboxy group, C1-C5 alkoxy group, C1-C4 alkoxycarbonyl group, C2-C4 alkanoyloxy group, C1-C4 alkyl-substituted amino group or a C1-C4 alkyl group which may be substituted by a substituent(s) selected from the group consisting of (a halogen atom, a hydroxy group and a carboxy group), or a pharmaceutically acceptable salt thereof.

    Dibenzocycloheptene compound
    3.
    发明授权
    Dibenzocycloheptene compound 失效
    二苯并环庚烯化合物

    公开(公告)号：US07309718B2

    公开(公告)日：2007-12-18

    申请号：US10481752

    申请日：2002-06-27

    申请人： Yoshiaki Kuroki ,  Hitoshi Ueno ,  Tetsushi Katsube ,  Tetsuo Kawaguchi ,  Eiji Okanari ,  Ichiro Tanaka ,  Masayuki Tanaka ,  Masahiko Hagihara

    发明人： Yoshiaki Kuroki ,  Hitoshi Ueno ,  Tetsushi Katsube ,  Tetsuo Kawaguchi ,  Eiji Okanari ,  Ichiro Tanaka ,  Masayuki Tanaka ,  Masahiko Hagihara

    IPC分类号： A61K31/19 ,  C07C61/00 ,  C07C63/00

    CPC分类号： C07D215/18 ,  C07D215/12

    摘要： The present invention discloses a dibenzocycloheptene compound represented by the formula (I): wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; —CH═CH—, formula; —CH2O—, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc., m: an integer of 1 to 4, n: an integer of 1 to 3, represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof and a medical composition containing the same as an effective ingredient which has leukotriene C4 antagonistic action and leukotriene E4 antagonistic action in addition to potent leukotriene D4 antagonistic action, and useful as antiasthmatic agent, antiallergic agent and anti-inflammatory agent.

    摘要翻译： 本发明公开了式（I）表示的二苯并环庚烯化合物：其中R 1：氢原子，卤素原子等，R 2：氢原子，卤素原子 等，含有1〜3个选自氮原子，氧原子和硫原子的杂原子的5元或6元杂芳族环基和杂芳环基等可以具有 卤素原子，氮原子等作为取代基，B：式; -CH-CH-，式 -CH 2 O - 等，Y：C 1 -C 10亚烷基，其可以具有卤素原子等作为取代基（ s）等，Z：可被保护的羧基等，m：1〜4的整数，n：1〜3的整数，表示单键或双键 ，或其药学上可接受的盐和含有与有效成分相同的药物组合物，除了有效的白三烯外，还具有白三烯C 4拮抗作用和白三烯E 4拮抗作用 D 4拮抗作用，可用作止喘剂，抗过敏剂和抗炎剂。

    Trifluoromethylquinolinecarboxylic acid derivative
    7.
    发明授权
    Trifluoromethylquinolinecarboxylic acid derivative 失效
    三氟甲基喹啉羧酸衍生物

    公开(公告)号：US06034086A

    公开(公告)日：2000-03-07

    申请号：US154464

    申请日：1998-09-16

    申请人： Tomio Kimura ,  Tetsushi Katsube ,  Takashi Nishigaki

    发明人： Tomio Kimura ,  Tetsushi Katsube ,  Takashi Nishigaki

    IPC分类号： C07D401/04 ,  A61K31/4709 ,  A61P31/18 ,  C07D215/56 ,  C07D295/00 ,  A61K31/495 ,  A61K31/50 ,  C07D401/00 ,  C07D403/00

    CPC分类号： C07D215/56

    摘要： This invention relates to a 8-trifluoromethylquinolinecaboxylic acid derivative represented by the following formula (I): ##STR1## (wherein R.sup.1 represents a lower alkyl group, a halogeno-lower alkyl group or a cycloalkyl group, R.sup.2 represents a phenyl group which may be substituted by R.sup.0, a 5-membered or 6-membered aromatic heteromonocyclic ring group containing 1 or 2 hetero atoms selected from N, O and S, which may be substituted by R.sup.0, or an aromatic heterocyclic fused ring group in which the said aromatic heteromonocyclic ring group and a benzene ring are fused, R.sup.0 represents a group selected from a halogen, a lower alkyl, a fluorine-substituted lower alkyl, a lower alkoxy or a lower alkylthio, R.sup.3 represents hydrogen or a lower alkyl group, and m represents an integer of 2 or 3.) or a pharmaceutically acceptable salt thereof or an ester thereof.

    摘要翻译： 本发明涉及由下式（I）表示的8-三氟甲基喹啉代羧酸衍生物：其中R1表示低级烷基，卤代低级烷基或环烷基，R2表示可被R0取代的苯基 含有可被R 0取代的选自N，O和S的1或2个杂原子的5元或6元芳族杂单环环基或芳族杂环稠合环基，其中所述芳族杂单环环基和 苯环稠合，R 0表示选自卤素，低级烷基，氟取代的低级烷基，低级烷氧基或低级烷硫基，R 3表示氢或低级烷基，m表示2的整数 或3.）或其药学上可接受的盐或其酯。