Devices for Single-Molecule Sequencing, Including Related Methods and Processes

    公开(公告)号:US20220326214A1

    公开(公告)日:2022-10-13

    申请号:US17176371

    申请日:2021-02-16

    Inventor: Hendrik Postma

    Abstract: Processes for conductive material nanogap formation have been developed that include: providing a base material, wherein the base material is either solid or comprises a micropore that extends through the first layered material, and wherein the micropore comprises a top opening, a bottom opening, and a volume boundary, applying a conductive material sheet to the first layered material, wherein the conductive material sheet covers the top opening of the micropore, applying two conducting electrodes to the conductive material sheet, so that each one of the conducting electrodes is positioned on either side of the micropore, applying an etch mask that covers at least a part of the conductive material sheet, the top opening of the micropore (if present), or a combination thereof, applying a passivation layer over at least the etch mask, fabricating a hole in the passivation layer directly above the top opening of the micropore, and applying at least one voltage pulse through the at least one conducting electrode to create a nanogap in the conductive material sheet, wherein the nanogap is over and open to the top opening of the micropore. In some embodiments, the micropore and the nanogap are fabricated simultaneously.

    Devices for single-molecule sequencing, including related methods and processes

    公开(公告)号:US12085558B2

    公开(公告)日:2024-09-10

    申请号:US17176371

    申请日:2021-02-16

    Inventor: Hendrik Postma

    CPC classification number: G01N33/48721 C12Q1/6869 G01N27/3278 B82Y15/00

    Abstract: Processes for conductive material nanogap formation have been developed that include: providing a base material, wherein the base material is either solid or comprises a micropore that extends through the first layered material, and wherein the micropore comprises a top opening, a bottom opening, and a volume boundary, applying a conductive material sheet to the first layered material, wherein the conductive material sheet covers the top opening of the micropore, applying two conducting electrodes to the conductive material sheet, so that each one of the conducting electrodes is positioned on either side of the micropore, applying an etch mask that covers at least a part of the conductive material sheet, the top opening of the micropore (if present), or a combination thereof, applying a passivation layer over at least the etch mask, fabricating a hole in the passivation layer directly above the top opening of the micropore, and applying at least one voltage pulse through the at least one conducting electrode to create a nanogap in the conductive material sheet, wherein the nanogap is over and open to the top opening of the micropore. In some embodiments, the micropore and the nanogap are fabricated simultaneously.

    Longer-Lived Ruthenium Olefin Metathesis Catalysts Supported by Hemi-Labile Carbene Ligands

    公开(公告)号:US20210138444A1

    公开(公告)日:2021-05-13

    申请号:US17096001

    申请日:2020-11-12

    Abstract: Contemplated subject matter disclosed herein relates generally to organometallic olefin metathesis catalysts, and more particularly to longer-lived olefin metathesis catalysts supported by hemi-labile carbene ligands that bear an arm with one or more donor ligands, as well as the use of such catalysts in metathesis reactions of olefins and olefin compounds. The contemplated subject matter has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry. This contemplated subject matter serves to reduce the cost of olefin metathesis (OM) processes including in olefin metathesis polymerizations, conversion of vegetable oils into chemicals, and processes in the petrochemical industry. This contemplated subject matter reduces the cost of OM processes by providing OM catalysts that are longer-lived and lead to higher turnover numbers, hence requiring less catalyst to convert a given amount of substrate(s). Considering that the OM catalyst is the most expensive part of some OM processes, longer-lived OM catalysts have the benefit of reducing the overall cost of the OM processes.

    Integration of User Emotions for a Smartphone or Other Communication Device Environment

    公开(公告)号:US20190332247A1

    公开(公告)日:2019-10-31

    申请号:US16398656

    申请日:2019-04-30

    Inventor: Li Liu Dragos Guta

    Abstract: Methods of real-time emoji and emoticon production are disclosed that include: determining, by a computing device, at least one first emotional state of a user from information, wherein the at least one first emotional state is a presently-identified emotional state of the user; providing an emoji or emoticon production template system, wherein the template system includes at least one physical attribute of the user; and utilizing the emoji or emoticon production template system to: analyze the presently-identified emotional state of the user; determine a suitable map of the presently-identified state of the user; map the presently-identified state of the user on an emoji or emoticon production template; produce at least one unique emoji or emoticon based on the map; provide the at least one unique emoji or emoticon to the user, wherein the user selects the at least one unique emoji or emoticon and includes the at least one unique emoji or emoticon in a text message, a direct message, an electronic mail message, or a combination thereof.

    Integration of user emotions for a smartphone or other communication device environment

    公开(公告)号:US11573679B2

    公开(公告)日:2023-02-07

    申请号:US16398656

    申请日:2019-04-30

    Inventor: Li Liu Dragos Guta

    Abstract: Methods of real-time emoji and emoticon production are disclosed that include: determining, by a computing device, at least one first emotional state of a user from information, wherein the at least one first emotional state is a presently-identified emotional state of the user; providing an emoji or emoticon production template system, wherein the template system includes at least one physical attribute of the user; and utilizing the emoji or emoticon production template system to: analyze the presently-identified emotional state of the user; determine a suitable map of the presently-identified state of the user; map the presently-identified state of the user on an emoji or emoticon production template; produce at least one unique emoji or emoticon based on the map; provide the at least one unique emoji or emoticon to the user, wherein the user selects the at least one unique emoji or emoticon and includes the at least one unique emoji or emoticon in a text message, a direct message, an electronic mail message, or a combination thereof.

    High Efficiency Thermal Management Devices For Use With Electronic Components Having High Heat Flux Values

    公开(公告)号:US20220232728A1

    公开(公告)日:2022-07-21

    申请号:US17513105

    申请日:2021-10-28

    Abstract: High efficiency heat management devices for use with electronic components, are disclosed and include: at least one jet inlet channel, at least one non-uniform channel area or uniform channel area, at least two exit channels, at least one heat spreader conductive plate, wherein the at least one non-uniform channel area or uniform channel area is bounded by the at least one jet inlet channel, the at least two exit channels, and the at least one heat spreader conductive plate, and at least one porous component or at least one foam component, wherein the at least one porous component or at least one foam component at least partially fills the at least one non-uniform channel area or uniform channel area.

Patent Agency Ranking