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公开(公告)号：US12109242B2
公开(公告)日：2024-10-08
申请号：US17074118
申请日：2020-10-19
发明人： Carla F. Kim , Sharon M. Louie , Erhan Ararat , David Raiser
CPC分类号： A61K35/42 , A01K67/0271 , A61K9/007 , A61K9/0073 , A61K45/06 , A61K49/0008 , C12N5/0062 , C12N5/0688 , C12N5/0697 , A01K2207/12 , A01K2227/105 , A01K2267/0337 , C12N2506/02 , C12N2506/27 , C12N2506/45 , C12N2513/00
摘要： Various aspects described herein provide methods of generating alveolar or alveolar/airway organoids from a population of lung cells to differentiate into alveolar or alveolar/airway organoids. Also provided herein are methods and compositions for treating lung disease comprising transplantation of the alveolar or alveolar/airway organoids, or a cell isolated therefrom to a subject.
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公开(公告)号：US20240318235A1
公开(公告)日：2024-09-26
申请号：US18739955
申请日：2024-06-11
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12N9/10 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/53
CPC分类号： C12Q1/6827 , C12N9/1007 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/5308 , C12N2501/70 , C12N2501/71 , C12N2501/724 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US12097172B2
公开(公告)日：2024-09-24
申请号：US17679842
申请日：2022-02-24
CPC分类号： A61K31/18 , A61K31/426 , A61K45/06 , A61P3/10 , A61P13/12 , G01N33/68 , A61K31/18 , A61K2300/00
摘要： Embodiments herein disclose methods relating to diabetic nephropathy (DN); methods for preventing the onset and also for preventing the progressing of DN, as well as the treatment of DN in diabetic subjects comprising administering reparixin and/or ladarixin which are inhibitors of CXCL8 receptor CXCR1 and CXCR2 activation.
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公开(公告)号：US20240294641A1
公开(公告)日：2024-09-05
申请号：US18005286
申请日：2021-07-13
发明人： Frederick W. ALT , Ming TIAN , Hwei-Ling CHENG
CPC分类号： C07K16/2818 , A61K47/6849 , C07K2317/21 , C07K2317/24 , C07K2317/565
摘要： The technology described herein is directed to novel anti-PD1 antibody reagents (e.g., antibodies, antigen-binding fragments thereof, and/or chimeric antigen receptors). Also described herein are antibody-drug conjugates or kits comprising the disclosed antibody reagents, as well as methods of treating an autoimmune or auto-inflammatory disorder by administering the disclosed antibody reagents.
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公开(公告)号：US12064425B2
公开(公告)日：2024-08-20
申请号：US17262540
申请日：2019-07-26
发明人： Bing Chen , Gary Frey , Tianshu Xiao
IPC分类号： A61K31/4709
CPC分类号： A61K31/4709
摘要： Described herein are compounds that inhibits the membrane proximal external region (MPER) of a viral envelope (Env), as well as and compositions thereof. Further provided herein are methods for treating or preventing a viral infection comprises administering to a subject in need thereof an agent or compound that inhibits the MPER of a viral Env. In certain embodiments, the viral infection is an HIV infection.
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6.发明公开公开(公告)号：US20240269169A1
公开(公告)日：2024-08-15
申请号：US18401135
申请日：2023-12-29
申请人： The Children's Medical Center Corporation , Ospedale San Raffaele S.r.l. , Politecnico di Milano , Fondazione Telethon ETS , Dana-Farber Cancer Institute, Inc.
发明人： Alessandra BIFFI , Marco PEVIANI , Davide MOSCATELLI , Alessia CAPOTONDO , Rita MILAZZO , Umberto CAPASSO PALMIERO
CPC分类号： A61K35/12 , A61P25/28 , C12N15/86 , A01K67/0271 , A01K2227/10 , A61K9/0019 , A61K2035/124 , A61K45/06 , C12N2740/15043
摘要： The present invention provides compositions and methods for the treatment or prevention of a neurological disease or disorder of the central nervous system (e.g., a storage disorder, lysosomal storage disorder, neurodegenerative disease, etc.) by reconstitution of brain myeloid cell and microglia upon transplantation of hematopoietic cells enriched in microglia reconstitution potential. The invention also provides compositions and methods for ablating and reconstituting microglia.
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公开(公告)号：US20240091405A1
公开(公告)日：2024-03-21
申请号：US18520488
申请日：2023-11-27
发明人： Martha M. MURRAY
CPC分类号： A61L27/24 , A61L27/3633 , A61L27/3691 , A61L27/56 , C07K14/78 , C12P21/00 , A61K38/00
摘要： Methods for preparing and using collagen extracts and collagen scaffolds are provided. Additionally, methods and related kits for the repair of articular tissue using the collagen material are provided.
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公开(公告)号：US11878057B2
公开(公告)日：2024-01-23
申请号：US17547639
申请日：2021-12-10
申请人： TRUSTEES OF BOSTON UNIVERSITY , THE CHILDREN'S MEDICAL CENTER CORPORATION , MINISTRY OF FISHERIES AND MARINE RESOURCES DEVELOPMENT
IPC分类号： A61K31/739 , A61K39/00 , A61K39/02 , A61K39/39
CPC分类号： A61K39/39 , A61K31/739 , A61K39/02 , A61K2039/55572 , A61K2039/6087
摘要： Provided herein are lipid A molecules engineered from Moritella lipopolysaccharides and uses thereof.
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公开(公告)号：US20230338529A1
公开(公告)日：2023-10-26
申请号：US18019627
申请日：2021-08-05
发明人： Zhigang HE , Yi LI , Xuelian HE
IPC分类号： A61K31/336 , A61K39/00 , A61P17/02 , A61K38/55 , A61K31/404 , A61P25/00
CPC分类号： A61K39/4614 , A61K31/336 , A61K31/404 , A61K38/55 , A61K39/4633 , A61K39/4637 , A61K39/464 , A61K39/4644 , A61K39/464402 , A61K39/464429 , A61P17/02 , A61P25/00
摘要： Provided herein are compositions and methods for reducing neuroinflammation and treating neurodegenerative diseases using proteinase inhibitors. The invention also provides methods for reducing post-injury scar formation in the central nervous system.
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10.发明公开公开(公告)号：US20230298702A1
公开(公告)日：2023-09-21
申请号：US18129274
申请日：2023-03-31
发明人： Frederick W. ALT , Jiazhi HU , Sherry LIN , Zhou DU , Yu ZHANG , Huan CHEN
IPC分类号： G16B30/10 , G16B30/00 , C12Q1/6827 , C12Q1/6858 , C12Q1/6869 , C12Q1/686 , C12Q1/6855
CPC分类号： G16B30/10 , G16B30/00 , C12Q1/6827 , C12Q1/6858 , C12Q1/6869 , C12Q1/686 , C12Q1/6855 , C12Q2549/119
摘要： Described herein are methods and assays for detection of recombination and/or rearrangement events in a cell. In some embodiments, the methods and/or assays relate to Linear Amplification Mediated (LAM)-PCR. In some embodiments, the recombination event is a V(D)J recombination event.
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