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1.
公开(公告)号:US08110382B2
公开(公告)日:2012-02-07
申请号:US12189912
申请日:2008-08-12
申请人: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
发明人: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
CPC分类号: C07C51/48 , C07C51/42 , C07C51/487 , C12P7/42 , C07C59/06
摘要: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.
摘要翻译: 提供从甲醛和氰化氢生产乙醇酸的方法。 更具体地,使热处理的甲醛和氰化氢反应以制备具有低浓度杂质的乙醇腈。 随后使用具有源自Acidovorax facilis 72W(ATCC 57746)的腈水解酶活性的酶催化剂将乙醇腈转化为乙醇酸铵水溶液。 使用本文所述的各种方法,从乙醇酸水溶液中以酸或盐的形式回收乙醇酸。
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公开(公告)号:US08084238B2
公开(公告)日:2011-12-27
申请号:US12189902
申请日:2008-08-12
申请人: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
发明人: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
CPC分类号: C07C51/48 , C07C51/42 , C07C51/487 , C12P7/42 , C07C59/06
摘要: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.
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公开(公告)号:US07741083B2
公开(公告)日:2010-06-22
申请号:US12189869
申请日:2008-08-12
申请人: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
发明人: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
CPC分类号: C07C51/48 , C07C51/42 , C07C51/487 , C12P7/42 , C07C59/06
摘要: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.
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公开(公告)号:US20100145074A1
公开(公告)日:2010-06-10
申请号:US12328078
申请日:2008-12-04
申请人: THOMAS FOO , Mark Andrew Harmer , Keith W. Hutchenson , Christopher P. Junk , Berlyn R. Mellein , Aaron Minter
发明人: THOMAS FOO , Mark Andrew Harmer , Keith W. Hutchenson , Christopher P. Junk , Berlyn R. Mellein , Aaron Minter
IPC分类号: C07D207/46
CPC分类号: C07D207/27
摘要: This invention relates to compounds useful as ionic liquids that are based on an N-substituted pyrrolidinone and incorporate a pendant ammonium cation that is spaced from the pyrrolidone ring by a variable length linker.
摘要翻译: 本发明涉及可用作离子液体的化合物,其基于N-取代的吡咯烷酮并掺入通过可变长度连接体与吡咯烷酮环间隔开的侧铵阳离子。
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公开(公告)号:US20100145073A1
公开(公告)日:2010-06-10
申请号:US12328057
申请日:2008-12-04
申请人: THOMAS FOO , Mark Andrew Harmer , Keith W. Hutchenson , Christopher P. Junk , Berlyn R. Mellein , Aaron Minter
发明人: THOMAS FOO , Mark Andrew Harmer , Keith W. Hutchenson , Christopher P. Junk , Berlyn R. Mellein , Aaron Minter
IPC分类号: C07D207/12
CPC分类号: C07D207/27
摘要: This invention relates to compounds useful as ionic liquids that are based on an N-substituted pyrrolidinone and incorporate a pendant ammonium cation that is spaced from the pyrrolidone ring by a variable length linker, which compounds may be represented by the structure of the following Formula I: wherein: (a) Z is —(CH2)n—, wherein n is an integer from 2 to 12; (b) R2, R3 and R4 are each independently H or a C1 to C6 straight-chain or branched alkyl group; and (c) A−is levulinate, —[CF3—O—CFHCF2SO3]—, [CF3CF2OCFHCF2SO3]—, or [CF3CF2CF2OCFHCF2SO3]—.
摘要翻译: 本发明涉及可用作离子液体的化合物,其基于N-取代的吡咯烷酮并掺入通过可变长度的连接体与吡咯烷酮环间隔的侧铵阳离子,该化合物可以由下式I :其中:(a)Z是 - (CH 2)n - ,其中n是2至12的整数; (b)R2,R3和R4各自独立地为H或C1-C6直链或支链烷基; 和(c)A-是乙酰丙酸酯, - [CF 3 -O-CFHCF 2 SO 3] - ,[CF 3 CF 2 OCFHCF 2 SO 3] - 或[CF 3 CF 2 CF 2 OCFHCF 2 SO 3] - 。
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公开(公告)号:US07635789B2
公开(公告)日:2009-12-22
申请号:US11834125
申请日:2007-08-06
申请人: Thomas Foo
发明人: Thomas Foo
IPC分类号: C07C235/06 , C07C233/05 , C09G1/06 , C09K13/00 , A61K47/16 , C11D1/00
CPC分类号: C09G1/06 , B01F17/0035 , B01F17/0042 , C07C235/08 , C08K5/02 , C08K5/20 , C09D7/63 , C09D11/03 , C11D1/004
摘要: Compounds of formula (I) and formula (III): wherein A is —F or —CF3; Rf is independently C1-C6 perfluorinated linear or branched alkyl optionally interrupted by one or more oxygens; Ro is a linear or branched aliphatic group of about 10 to about 100 carbon atoms, interrupted by about 5 to about 50 ether oxygens, wherein the ratio of ether oxygen to carbon atoms is about 1:2 to about 1:3; and wherein each carbon atom has at most one ether oxygen atom bonded to it, and covalent bonding between ether oxygen atoms is absent; m is an integer of 1 to 3; Y−m is an anionic radical selected from the group consisting of halide, C1-C6 carboxylate, carbonate, hydrocarbonate, sulfate, hydrosulfate, C1-C6 sulfonate, phosphate, hydrophosphate, and dihydrophosphate. Further embodiments include methods of lowering surface tension of a medium comprising contacting the medium with a composition of formula (I), (III), or a mixture thereof.
摘要翻译: 式(I)和式(III)的化合物:其中A是-F或-CF 3; Rf独立地是C1-C6全氟化的直链或支链烷基,任选被一个或多个氧中断; Ro是约10至约100个碳原子的直链或支链脂族基团,间隔约5至约50个醚氧,其中醚氧与碳原子的比例为约1:2至约1:3; 并且其中每个碳原子具有至多一个与其键合的醚氧原子,并且不存在醚氧原子之间的共价键; m为1〜3的整数。 Y-m是选自卤化物,C 1 -C 6羧酸盐,碳酸盐,烃酸盐,硫酸盐,硫酸氢盐,C 1 -C 6磺酸盐,磷酸盐,氢磷酸盐和二氢磷酸盐的阴离子基团。 另外的实施方案包括降低培养基表面张力的方法,包括使培养基与式(I),(III)或其混合物的组合物接触。
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公开(公告)号:US20090011483A1
公开(公告)日:2009-01-08
申请号:US12189912
申请日:2008-08-12
申请人: Robert DiCosimo , Anna Panova , Jerrery Scott Thompson , Robert D. Fallon , Thomas Foo , F. Glenn Gallagher , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
发明人: Robert DiCosimo , Anna Panova , Jerrery Scott Thompson , Robert D. Fallon , Thomas Foo , F. Glenn Gallagher , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
IPC分类号: C12P7/42
CPC分类号: C07C51/48 , C07C51/42 , C07C51/487 , C12P7/42 , C07C59/06
摘要: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.
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8.
公开(公告)号:US07445917B2
公开(公告)日:2008-11-04
申请号:US11314905
申请日:2005-12-21
申请人: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
发明人: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
CPC分类号: C07C51/48 , C07C51/42 , C07C51/487 , C12P7/42 , C07C59/06
摘要: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.
摘要翻译: 提供从甲醛和氰化氢生产乙醇酸的方法。 更具体地,使热处理的甲醛和氰化氢反应以制备具有低浓度杂质的乙醇腈。 随后使用具有源自Acidovorax facilis 72W(ATCC 57746)的腈水解酶活性的酶催化剂将乙醇腈转化为乙醇酸铵水溶液。 使用本文所述的各种方法,从乙醇酸水溶液中以酸或盐的形式回收乙醇酸。
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9.
公开(公告)号:US08885904B2
公开(公告)日:2014-11-11
申请号:US13451228
申请日:2012-04-19
IPC分类号: G06K9/00
CPC分类号: A61B5/055 , G01R33/543
摘要: Systems and methods for landmark correction in Magnetic Resonance Imaging (MRI) are provided. One method includes acquiring at least one calibration image or at least one localizer image of an object, identifying in the calibration or localizer images a region of the object as a reference point, wherein the reference point defines a landmark position. The method further includes determining an offset between an initial landmark position and the identified landmark position. The method also includes using the determined offset for MRI.
摘要翻译: 提供了磁共振成像(MRI)中地标校正的系统和方法。 一种方法包括获取对象的至少一个校准图像或至少一个定位器图像,在校准或定位器图像中识别作为参考点的对象的区域,其中参考点定义界标位置。 该方法还包括确定初始界标位置与所识别的界标位置之间的偏移。 该方法还包括使用确定的MRI偏移。
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公开(公告)号:US20120012779A1
公开(公告)日:2012-01-19
申请号:US13259277
申请日:2010-03-31
IPC分类号: C09K5/04
CPC分类号: C09K5/047
摘要: This invention relates to a temperature adjustment device that executes an absorption cooling or heating cycle in which a lithium halide, typically a lithium bromide, absorbent is used.
摘要翻译: 本发明涉及一种执行吸收冷却或加热循环的温度调节装置,其中使用了卤化锂(通常为溴化锂)吸收剂。
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