摘要:
Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
摘要:
An impact of a memory latency time on repeat operations with a memory is reduced by providing a repeat start buffer for buffering a beginning of a data sequence to be repeatedly accessed, and a repeat switching unit, connected with the memory and the repeat start buffer, for switching therebetween for accessing the buffered beginning of the data sequence to be repeatedly accessed when the data sequence is to be repeated. In case of jump operations, a further reduction is achieved by providing a first and a second data buffer connectable with the memory for buffering data sequences, and a switching unit, connected with the data buffers for switching therebetween. The memory is accessible for each data buffer during an idle memory accessing time of the other data buffer for buffering a beginning of a data sequence to be accessed successively.
摘要:
Inhibition of the transcription of genes in higher eukaryotic cells by inhibiting the activation of NF-KB, wherein the cells are treated with substances which specifically inhibit the proteolytic degradation of IKB-.alpha. directly or indirectly. Process for screening substances which inhibit NF-KB activation by inhibiting the proteolytic degradation of IKB-.alpha.. Use of the substances for treating pathological conditions which can be traced back to undesirable gene expression controlled by NF-KB.
摘要:
A method for testing a device-under-test includes receiving, from at least one test channel circuit dedicated to communicate with an input/output pin of the device-under-test by means of at least one hardware resource, at least one logical control command describing a desired operation of the at least one hardware resource, and converting, by means of a resource controller, the at least one logical control command into at least one dedicated control command for the at least one hardware resource, wherein the at least one dedicated control command is adapted to be received by a physical implementation of the at least one hardware resource.
摘要:
Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Camitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
摘要:
A channel adapted for at least one of providing and receiving signals includes a channel clock domain, whereby said channel clock domain is under clock control of a channel clock. The channel clock domain includes at least one of: a drive path adapted for providing signals and a receive path adapted for receiving signals. The channel also includes a service clock domain adapted for at least one of providing data to and receiving data from said channel clock domain, whereby said service clock domain is under clock control of a service clock.
摘要:
Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
摘要:
Described is a multi-channel architecture comprising a central master clock generator for generating a central master clock signal and a plurality of channels connectable with inputs or outputs of a device. The multi-channel architecture further includes a channel master clock gate assigned to a respective channel of the plurality of channels, for receiving the central master clock signal and for generating a channel clock signal from the central master clock signal. The multi-channel architecture can be used in a tester arrangement, and preferably in an IC tester. The described multi-channel architecture allows clock signals to be provided for each one of the channels independent of other channels, e.g. to apply a continuous clock signal in one channel while the clock signal in other channels might be changed, e.g. in order to receive new timing edges as references for testing a DUT.
摘要:
A multi-channel architecture comprising a central facility that is under clock control of a central facility's clock signal, and a central transfer clock generator adapted for deriving a central transfer clock signal from the central facility's clock signal. The multi-channel architecture further comprises a set of n channels, with n being a natural number, wherein each channel is under clock control of one out of a plurality of clock signals. Each of the channels comprises a channel transfer clock generator adapted for deriving a channel transfer clock signal from a clock signal of the respective channel, wherein the central facility's clock signal and the clock signals of the channels comprise at least two different clock signals. The transfer clock period of the central transfer clock signal is substantially equal to each of the transfer clock periods of the channel transfer clock signals.
摘要:
A channel adapted for at least one of providing and receiving signals comprises a channel clock domain, whereby said channel clock domain is under clock control of a channel clock. The channel clock domain comprises at least one of: a drive path adapted for providing signals and a receive path adapted for receiving signals. The channel further comprises a service clock domain adapted for at least one of providing data to and receiving data from said channel clock domain, whereby said service clock domain is under clock control of a service clock.