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    VARIABLE CURRENT DENSITY SINGLE NEEDLE ELECTROPORATION SYSTEM AND METHOD
    1.
    发明申请
    VARIABLE CURRENT DENSITY SINGLE NEEDLE ELECTROPORATION SYSTEM AND METHOD 审中-公开
    可变电流密度单针电气系统及方法

    公开(公告)号：US20110009807A1

    公开(公告)日：2011-01-13

    申请号：US12836163

    申请日：2010-07-14

    Applicant: Rune KJEKEN ,  Stephen Vincent KEMMERRER ,  Feng LIN ,  Dietmar RABUSSAY ,  Thomas Joseph KARDOS

    Inventor： Rune KJEKEN ,  Stephen Vincent KEMMERRER ,  Feng LIN ,  Dietmar RABUSSAY ,  Thomas Joseph KARDOS

    IPC: A61N1/30

    CPC classification number: A61N1/327 ,  A61N1/325 ,  C12M35/02 ,  C12N13/00 ,  C12N15/87

    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.

    Abstract translation: 本发明包括改进的电穿孔电极系统，其包括单针和环形或环形电极，其中电极的表面面积的差异大大降低了处理组织表面附近的电流密度，并且更集中的电流密度足够 仅在与单针电极的末端部分相邻的组织中进行电穿孔。 因此，本发明提供靶向用于电穿孔的特定组织，并且还应当提供减少处理组织中电流的感觉。

    METHOD OF CONTACTLESS MAGNETIC ELECTROPORATION
    2.
    发明申请
    METHOD OF CONTACTLESS MAGNETIC ELECTROPORATION 审中-公开
    无接触电磁法的方法

    公开(公告)号：US20100249488A1

    公开(公告)日：2010-09-30

    申请号：US12732195

    申请日：2010-03-26

    Applicant: Thomas Joseph Kardos ,  Dietmar Paul Rabussay

    Inventor： Thomas Joseph Kardos ,  Dietmar Paul Rabussay

    IPC: A61N2/04 ,  A61N2/00

    CPC classification number: A61N2/002 ,  A61N2/02

    Abstract: This invention provides a novel method of tissue electroporation that eliminates the need for electrodes that conduct electricity to the tissues. This invention creates electric currents and fields sufficient for porating cell membranes for improving the delivery of polynucleotides such as plasmid and linear DNA and RNA constructs, and polypeptides such as antigen protein constructs into mammalian eucaryotic cells purely by magnetic field pulses that does not require the use of contacting electrodes to conduct electric or ionic current. This invention thus provides a method for improving transfection and immunogenicity of pharmaceutical substances without direct contact with a living body, and may be called magnetopermeabilization. A concomitant aspect of the invention is the method by which a drug such as a solution containing DNA is delivered to a targeted tissue bed that is optimal in conjunction with magnetopermeabilization for maximal transgene expression and drug effect.

    Abstract translation: 本发明提供了组织电穿孔的新方法，其消除了对组织传导电的电极的需要。 本发明产生电流和场，足以使细胞膜用于改善多核苷酸如质粒和线性DNA和RNA构建体的递送，以及多肽例如抗原蛋白构建体纯化通过不需要使用的磁场脉冲的哺乳动物真核细胞 接触电极以传导电离或离子电流。 因此，本发明提供了一种改善药物的转染和免疫原性而不与生物体直接接触的方法，也可称为磁共振。 本发明的伴随方面是将诸如含有DNA的溶液的药物递送至与用于最大转基因表达和药物作用的磁共振稳定化最佳的靶组织床的方法。

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